Publications by authors named "Stuart A Cook"

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Circulating Interleukin-6 Predicts Adverse Outcomes in Asians with Hypertrophic Cardiomyopathy.
Thu-Thao Le, Shiqi Lim, Chengxi Yang, Jennifer Ann Bryant, Yiying Han, Stuart Alexander Cook

MedComm (2020)· December 2025

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Sex Differences in the Genetic Causes of Dilated Cardiomyopathy.
Massimo Mangino, Kathryn A McGurk, Pantazis Theotokis, Rachel J Buchan, Clare R Stockwell, Stuart A Cook

J Am Coll Cardiol· August 2025

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Effects of sacubitril/valsartan on hypertensive heart disease: the REVERSE-LVH randomized phase 2 trial.
Vivian Lee, Mayank Dalakoti, Qishi Zheng, Desiree-Faye Toh, Redha Boubertakh, Stuart A Cook

Nat Commun· July 2025

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Interleukin-11 expressed in the polyp-enriched fibroblast subset is a potential therapeutic target in Peutz-Jeghers syndrome.
Eva Domènech-Moreno, Wei-Wen Lim, Melissa G Montrose, Myriam Sévigny, Anders Brandt, Stuart A Cook

J Pathol· May 2025

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Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings.
Sean L Zheng, Sean J Jurgens, Kathryn A McGurk, Xiao Xu, Chris Grace, Stuart A Cook

Nat Genet· March 2025

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Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.
Rafik Tadros, Sean L Zheng, Christopher Grace, Paloma Jordà, Catherine Francis, Stuart A Cook

Nat Genet· March 2025

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Interleukin 11 therapy causes acute left ventricular dysfunction.
Mark Sweeney, Katie O'Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Stuart A Cook

Cardiovasc Res· December 2024

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Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy.
Sean L Zheng, Albert Henry, Douglas Cannie, Michael Lee, David Miller, James P Cook, Stuart A Cook

Nat Genet· December 2024

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Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.
Benjamin Ng, Kevin Y Huang, Chee Jian Pua, Sivakumar Viswanathan, Wei-Wen Lim, Stuart A Cook

Nat Commun· October 2024

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Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.
Anissa A Widjaja, Wei-Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Stuart A Cook

Nature· August 2024

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Advancing precision medicine through the integration of clinical cardiovascular genetics - An Asian perspective.
Iswaree D Balakrishnan, Yasmin Bylstra, Nikki Fong, Nellie B S Chai, Sylvia Kam, Stuart A Cook

Genet Med Open· July 2024

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Sex Differences in the Clinical Presentation and Natural History of Dilated Cardiomyopathy.
Ruth Owen, Rachel Buchan, Michael Frenneaux, Julian W E Jarman, Resham Baruah, Stuart A Cook

JACC Heart Fail· February 2024

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Nonspecific Inhibition of IL6 Family Cytokine Signalling by Soluble gp130.
Anissa A Widjaja, Stuart A Cook

Int J Mol Sci· January 2024

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The Pathobiology of IL-11 in Kidney Disease: From Epithelial Cell to Fibroblast and Back Again.
Anissa A Widjaja, Stuart A Cook

Am J Pathol· December 2023

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Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy.
Lara Curran, Antonio de Marvao, Paolo Inglese, Kathryn A McGurk, Pierre-Raphaël Schiratti, Stuart A Cook

Circ Genom Precis Med· December 2023

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Understanding interleukin 11 as a disease gene and therapeutic target.
Stuart A Cook

Biochem J· December 2023

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The penetrance of rare variants in cardiomyopathy-associated genes: A cross-sectional approach to estimating penetrance for secondary findings.
Kathryn A McGurk, Xiaolei Zhang, Pantazis Theotokis, Kate Thomson, Andrew Harper, Stuart A Cook

Am J Hum Genet· September 2023

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The Pathobiology of Interleukin 11 in Mammalian Disease is Likely Explained by its Essential Evolutionary Role for Fin Regeneration.
Stuart A Cook

J Cardiovasc Transl Res· August 2023

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Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction.
Mark Sweeney, Katie O'Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Stuart A Cook

Int J Mol Sci· August 2023

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Sacubitril/valsartan versus valsartan in regressing myocardial fibrosis in hypertension: a prospective, randomized, open-label, blinded endpoint clinical trial protocol.
Vivian Lee, Qishi Zheng, Desiree-Faye Toh, Chee Jian Pua, Jennifer A Bryant, Stuart A Cook

Front Cardiovasc Med· August 2023

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Impact of Diabetes on Myocardial Fibrosis in Patients With Hypertension: The REMODEL Study.
Chee Jian Pua, Germaine Loo, Michelle Kui, Wai Lun Moy, An-An Hii, Stuart A Cook

Circ Cardiovasc Imaging· July 2023

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IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome.
Benjamin Ng, Chen Xie, Liping Su, Fathima F Kuthubudeen, Xiu-Yi Kwek, Stuart A Cook

Arterioscler Thromb Vasc Biol· May 2023

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Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.
Rafik Tadros, Sean L Zheng, Christopher Grace, Paloma Jordà, Catherine Francis, Stuart A Cook

medRxiv· February 2023

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Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.
Anissa A Widjaja, Sivakumar Viswanathan, Shamini G Shekeran, Eleonora Adami, Wei-Wen Lim, Stuart A Cook

Nat Commun· December 2022

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Genetic Architecture of Acute Myocarditis and the Overlap With Inherited Cardiomyopathy.
Amrit S Lota, Mark R Hazebroek, Pantazis Theotokis, Rebecca Wassall, Sara Salmi, Stuart A Cook

Circulation· October 2022

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