Publications by authors named "Stuart Hazeldine"

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Development of functional poly(amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids.
Yan Wang, Stuart T Hazeldine, Jing Li, David Oupický

Adv Healthc Mater· April 2015

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Self-immolative polycations as gene delivery vectors and prodrugs targeting polyamine metabolism in cancer.
Yu Zhu, Jing Li, Shrey Kanvinde, Zhiyi Lin, Stuart Hazeldine

Mol Pharm· February 2015

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Cyclam-based polymeric copper chelators for gene delivery and potential PET imaging.
Jing Li, Yu Zhu, Stuart T Hazeldine, Steven M Firestine, David Oupický

Biomacromolecules· October 2012

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Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1.
Stuart Hazeldine, Boobalan Pachaiyappan, Nora Steinbergs, Shannon Nowotarski, Allison S Hanson

J Med Chem· September 2012

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Dual-function CXCR4 antagonist polyplexes to deliver gene therapy and inhibit cancer cell invasion.
Jing Li, Yu Zhu, Stuart T Hazeldine, Chunying Li, David Oupický

Angew Chem Int Ed Engl· August 2012

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Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota.
Colin C Hanfrey, Bruce M Pearson, Stuart Hazeldine, Jeongmi Lee, Duncan J Gaskin

J Biol Chem· December 2011

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Polyamine-based small molecule epigenetic modulators.
Shiv K Sharma, Stuart Hazeldine, Michael L Crowley, Allison Hanson, Ross Beattie

Medchemcomm· November 2011

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Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.
Bhaskar Gopishetty, Stuart Hazeldine, Soumava Santra, Mark Johnson, Gyan Modi

J Med Chem· April 2011

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Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.
Swati Biswas, Stuart Hazeldine, Balaram Ghosh, Ingrid Parrington, Eldo Kuzhikandathil

J Med Chem· May 2008

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The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80.
David Kessel, John J Reiners, Stuart T Hazeldine, Lisa Polin, Jerome P Horwitz

Mol Cancer Ther· January 2007

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Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters.
Shijun Zhang, Fernando Fernandez, Stuart Hazeldine, Jeffrey Deschamps, Juan Zhen

J Med Chem· July 2006

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Synthesis and biological evaluation of conformationally constrained analogs of the antitumor agents XK469 and SH80. Part 5.
Stuart T Hazeldine, Lisa Polin, Juiwanna Kushner, Kathryn White, Thomas H Corbett

Bioorg Med Chem· April 2006

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Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4.
Stuart T Hazeldine, Lisa Polin, Juiwanna Kushner, Kathryn White, Thomas H Corbett

Bioorg Med Chem· June 2005

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Part 3: synthesis and biological evaluation of some analogs of the antitumor agents, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid, and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid.
Stuart T Hazeldine, Lisa Polin, Juiwanna Kushner, Kathryn White, Thomas H Corbett

Bioorg Med Chem· February 2005

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II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469).
Stuart T Hazeldine, Lisa Polin, Juiwanna Kushner, Kathryn White, Nicole M Bouregeois

J Med Chem· July 2002

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Preclinical efficacy evaluations of XK-469: dose schedule, route and cross-resistance behavior in tumor bearing mice.
Lisa Polin, Kathryn White, Juiwanna Kushner, Jennifer Paluch, Chiab Simpson, Stuart Hazeldine

Invest New Drugs· February 2002

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Lack of in vitro-in vivo correlation of a novel investigational anticancer agent, SH 30.
Srinivasu Poondru, Ralph E Parchment, Vivek Purohit, Patricia LoRusso, Jerome P Horwitz, Stuart T Hazeldine

Invest New Drugs· February 2002

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