Publications by authors named "Subharekha Raghavan"

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Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947.
Linda Brockunier, John Stelmach, Jian Guo, Tracy Spencer, Keith Rosauer, Subharekha Raghavan

Bioorg Med Chem Lett· November 2020

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Selective Formation of Functionalized α-Quaternary Malononitriles toward 5,5-Disubstituted Pyrrolopyrimidinones.
Alan Whitehead, Yong Zhang, Jamie McCabe Dunn, Edward C Sherer, Yu-Hong Lam, Subharekha Raghavan

Org Lett· September 2017

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The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties.
Jason E Imbriglio, Daniel DiRocco, Rena Bodner, Subharekha Raghavan, Weichun Chen

Bioorg Med Chem Lett· May 2011

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GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.
Jason E Imbriglio, Sookhee Chang, Rui Liang, Subharekha Raghavan, Darby Schmidt

Bioorg Med Chem Lett· August 2010

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Anthranilic acid replacements in a niacin receptor agonist.
Darby Schmidt, Abigail Smenton, Subharekha Raghavan, Hong Shen, Fa-Xiang Ding

Bioorg Med Chem Lett· June 2010

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Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
Hong C Shen, Fa-Xiang Ding, Subharekha Raghavan, Qiaolin Deng, Silvi Luell

J Med Chem· March 2010

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Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia.
Darby Schmidt, Abigail Smenton, Subharekha Raghavan, Ester Carballo-Jane, Silvi Lubell

Bioorg Med Chem Lett· August 2009

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GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a.
Jason E Imbriglio, Sookhee Chang, Rui Liang, Subharekha Raghavan, Darby Schmidt

Bioorg Med Chem Lett· April 2009

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Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists.
Subharekha Raghavan, G Scott Tria, Hong C Shen, Fa-Xiang Ding, Andrew K Taggart

Bioorg Med Chem Lett· June 2008

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Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus.
Subharekha Raghavan, Zhijian Lu, Teresa Beeson, Kevin T Chapman, William A Schleif

Bioorg Med Chem Lett· October 2007

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Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.
Zhijian Lu, Subharekha Raghavan, Joann Bohn, Mark Charest, Mark W Stahlhut

Bioorg Med Chem Lett· May 2003

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Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.
Subharekha Raghavan, Zheng Yang, Ralph T Mosley, William A Schleif, Lori Gabryelski

Bioorg Med Chem Lett· October 2002

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