Publications by authors named "Subhash C Annedi"

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Cell-permeable inhibitors of neuronal nitric oxide synthase open new prospects for the treatment of neurological disorders.
Subhash C Annedi

J Med Chem· February 2015

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Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.
Subhash C Annedi, Shawn P Maddaford, Jailall Ramnauth, Paul Renton, Taras Rybak

Eur J Med Chem· September 2012

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Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).
Subhash C Annedi, Jailall Ramnauth, Michele Cossette, Shawn P Maddaford, Peter Dove

Bioorg Med Chem Lett· April 2012

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First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.
Gabriela Mladenova, Subhash C Annedi, Jailall Ramnauth, Shawn P Maddaford, Suman Rakhit

J Med Chem· April 2012

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3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Subhash C Annedi, Shawn P Maddaford, Jailall Ramnauth, Paul Renton, Joanne Speed

Bioorg Med Chem Lett· March 2012

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1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.
Jailall Ramnauth, Paul Renton, Peter Dove, Subhash C Annedi, Joanne Speed

J Med Chem· March 2012

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Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.
Subhash C Annedi, Jailall Ramnauth, Shawn P Maddaford, Paul Renton, Suman Rakhit

J Med Chem· January 2012

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Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Subhash C Annedi, Shawn P Maddaford, Gabriela Mladenova, Jailall Ramnauth, Suman Rakhit

J Med Chem· October 2011

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1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
Paul Renton, Joanne Speed, Shawn Maddaford, Subhash C Annedi, Jailall Ramnauth

Bioorg Med Chem Lett· September 2011

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1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
Shawn Maddaford, Paul Renton, Joanne Speed, Subhash C Annedi, Jailall Ramnauth

Bioorg Med Chem Lett· September 2011

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Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Jailall Ramnauth, Joanne Speed, Shawn P Maddaford, Peter Dove, Subhash C Annedi

J Med Chem· August 2011

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Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
Joanne Patman, Namrta Bhardwaj, Jailall Ramnauth, Subhash C Annedi, Paul Renton

Bioorg Med Chem Lett· May 2007

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Engineering d-amino acid containing novel protease inhibitors using catalytic site architecture.
Subhash C Annedi, Farooq Biabani, Ewa Poduch, Baskar M Mannargudi, Kanchana Majumder

Bioorg Med Chem· January 2006

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An unprecedented twist to ODCase catalytic activity.
Masahiro Fujihashi, Angelica M Bello, Ewa Poduch, Lianhu Wei, Subhash C Annedi

J Am Chem Soc· November 2005

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Novel fluoropeptidomimetics: synthesis, stability studies and protease inhibition.
Subhash C Annedi, Kanchana Majumder, Lianhu Wei, Catherine E Oyiliagu, Sheeba Samson

Bioorg Med Chem· April 2005

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Design and synthesis of novel fluoropeptidomimetics as potential mimics of the transition state during peptide hydrolysis.
Subhash C Annedi, Weiyong Li, Sheeba Samson, Lakshmi P Kotra

J Org Chem· February 2003

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