Publications by authors named "Suchithra Menon"

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AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth.
Yann Cormerais, Samuel C Lapp, Krystle C Kalafut, Madi Y Cissé, Jong Shin, Suchithra Menon

Dev Cell· October 2025

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A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner.
Aude Sylvain, Natacha Stoehr, Fupeng Ma, Artiom Cernijenko, Martin Schröder, Suchithra Menon

Cell Chem Biol· July 2025

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AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth.
Yann Cormerais, Samuel C Lapp, Krystle C Kalafut, Madi Y Cissé, Jong Shin, Suchithra Menon

bioRxiv· September 2024

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Molecular targets and approaches to restore autophagy and lysosomal capacity in neurodegenerative disorders.
Julie Bastien, Suchithra Menon, Mirko Messa, Beat Nyfeler

Mol Aspects Med· December 2021

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An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells.
Marek J Kobylarz, Jonathan M Goodwin, Zhao B Kang, John W Annand, Sarah Hevi, Suchithra Menon

PLoS One· September 2020

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Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao, Suchithra Menon

Nat Cell Biol· May 2019

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Bile acid analogues are activators of pyrin inflammasome.
Irina Alimov, Suchithra Menon, Nadire Cochran, Rob Maher, Qiong Wang

J Biol Chem· March 2019

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Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism.
Ghayda M Mirzaa, Catarina D Campbell, Nadia Solovieff, Carleton Goold, Laura A Jansen, Suchithra Menon

JAMA Neurol· July 2016

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
William E Dowdle, Beat Nyfeler, Jane Nagel, Robert A Elling, Shanming Liu, Suchithra Menon

Nat Cell Biol· November 2014

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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan

Cell· February 2014

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Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao, Suchithra Menon

Nat Cell Biol· November 2013

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COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase.
Cheng Liu, Li-Quan Guo, Suchithra Menon, Dan Jin, Elah Pick

J Biol Chem· July 2013

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Cell signalling: nutrient sensing lost in cancer.
Suchithra Menon, Brendan D Manning

Nature· June 2013

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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Christian C Dibble, Winfried Elis, Suchithra Menon, Wei Qin, Justin Klekota

Mol Cell· August 2012

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Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.
Suchithra Menon, Jessica L Yecies, Hui H Zhang, Jessica J Howell, Justin Nicholatos

Sci Signal· March 2012

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Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.
Jessica L Yecies, Hui H Zhang, Suchithra Menon, Sihao Liu, Derek Yecies

Cell Metab· July 2011

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CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.
Tomohiko Tsuge, Suchithra Menon, Yingchun Tong, Ning Wei

Protein Cell· May 2011

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Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.
Huabo Su, Jie Li, Suchithra Menon, Jinbao Liu, Asangi R Kumarapeli

Circ Res· January 2011

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky

Mol Cell· July 2010

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Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome.
Suchithra Menon, Tomohiko Tsuge, Naoshi Dohmae, Koji Takio, Ning Wei

BMC Biochem· January 2008

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COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
Suchithra Menon, Hongbo Chi, Huiyong Zhang, Xing Wang Deng, Richard A Flavell

Nat Immunol· November 2007

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Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.
Elah Pick, On-Sun Lau, Tomohiko Tsuge, Suchithra Menon, Yingchun Tong

Mol Cell Biol· July 2007

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Purification of the COP9 signalosome from porcine spleen, human cell lines, and Arabidopsis thaliana plants.
Suchithra Menon, Vicente Rubio, Xiping Wang, Xing-Wang Deng, Ning Wei

Methods Enzymol· December 2005

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Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.
Karin Lykke-Andersen, Laura Schaefer, Suchithra Menon, Xing-Wang Deng, Jeffrey Boone Miller

Mol Cell Biol· October 2003

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The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.
Xiaoming Yang, Suchithra Menon, Karin Lykke-Andersen, Tomohiko Tsuge, Di Xiao

Curr Biol· April 2002

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