Publications by authors named "Sumit Middha"

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A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing.
John Ziegler, Jaclyn F Hechtman, Satshil Rana, Ryan N Ptashkin, Gowtham Jayakumaran, Sumit Middha

Nat Commun· January 2025

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Defining Novel DNA Virus-Tumor Associations and Genomic Correlates Using Prospective Clinical Tumor/Normal Matched Sequencing Data.
Chad M Vanderbilt, Anita S Bowman, Sumit Middha, Kseniya Petrova-Drus, Yi-Wei Tang

J Mol Diagn· May 2022

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Clinical Experience of Cerebrospinal Fluid-Based Liquid Biopsy Demonstrates Superiority of Cell-Free DNA over Cell Pellet Genomic DNA for Molecular Profiling.
Tejus A Bale, Soo-Ryum Yang, James P Solomon, Khedoudja Nafa, Sumit Middha

J Mol Diagn· June 2021

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A Pan-Cancer Study of Somatic TERT Promoter Mutations and Amplification in 30,773 Tumors Profiled by Clinical Genomic Sequencing.
Sounak Gupta, Chad M Vanderbilt, Yun-Te Lin, Jamal K Benhamida, Achim A Jungbluth, Sumit Middha

J Mol Diagn· February 2021

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Retained mismatch repair protein expression occurs in approximately 6% of microsatellite instability-high cancers and is associated with missense mutations in mismatch repair genes.
Jaclyn F Hechtman, Satshil Rana, Sumit Middha, Zsofia K Stadler, Alicia Latham

Mod Pathol· May 2020

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Identification of prognostic molecular biomarkers in 157 HPV-positive and HPV-negative squamous cell carcinomas of the oropharynx.
Snjezana Dogan, Bin Xu, Sumit Middha, Chad M Vanderbilt, Anita S Bowman

Int J Cancer· December 2019

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Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations.
Yoshiyuki Suehara, Deepu Alex, Anita Bowman, Sumit Middha, Ahmet Zehir

Clin Cancer Res· November 2019

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Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response.
Rajarsi Mandal, Robert M Samstein, Ken-Wing Lee, Jonathan J Havel, Hao Wang, Sumit Middha

Science· May 2019

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Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade.
Wassim Abida, Michael L Cheng, Joshua Armenia, Sumit Middha, Karen A Autio

JAMA Oncol· April 2019

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Outcome and molecular characteristics of non-invasive encapsulated follicular variant of papillary thyroid carcinoma with oncocytic features.
Bin Xu, Ed Reznik, R Michael Tuttle, Jeffrey Knauf, James A Fagin, Sumit Middha

Endocrine· April 2019

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Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions.
Emiliano Cocco, Jamal Benhamida, Sumit Middha, Ahmet Zehir, Kerry Mullaney

Cancer Res· March 2019

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Majority of -Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High.
Sumit Middha, Rona Yaeger, Jinru Shia, Zsofia K Stadler, Sarah King

JCO Precis Oncol· March 2019

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Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.
Alicia Latham, Preethi Srinivasan, Yelena Kemel, Jinru Shia, Chaitanya Bandlamudi, Sumit Middha

J Clin Oncol· February 2019

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Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA.
Jaclyn F Hechtman, Ghassan K Abou-Alfa, Zsofia K Stadler, Diana L Mandelker, Michael H A Roehrl, Sumit Middha

Hum Pathol· January 2019

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Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer.
Tara E Soumerai, Mark T A Donoghue, Chaitanya Bandlamudi, Preethi Srinivasan, Matthew T Chang, Sumit Middha

Clin Cancer Res· December 2018

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The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.
Pedram Razavi, Matthew T Chang, Guotai Xu, Chaitanya Bandlamudi, Dara S Ross, Sumit Middha

Cancer Cell· September 2018

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amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.
Pang-Dian Fan, Giuseppe Narzisi, Anitha D Jayaprakash, Elisa Venturini, Nicolas Robine, Sumit Middha

Proc Natl Acad Sci U S A· June 2018

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Gene Expression Signatures Characterized by Longitudinal Stability and Interindividual Variability Delineate Baseline Phenotypic Groups with Distinct Responses to Immune Stimulation.
Adam D Scheid, Virginia P Van Keulen, Sara J Felts, Steven C Neier, Sumit Middha

J Immunol· March 2018

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A FISH assay efficiently screens for BRAF gene rearrangements in pancreatic acinar-type neoplasms.
Lu Wang, Olca Basturk, Jiajing Wang, Ryma Benayed, Sumit Middha

Mod Pathol· January 2018

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Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer.
Yelena Y Janjigian, Francisco Sanchez-Vega, Philip Jonsson, Walid K Chatila, Jaclyn F Hechtman, Sumit Middha

Cancer Discov· January 2018

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Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.
Rona Yaeger, Walid K Chatila, Marla D Lipsyc, Jaclyn F Hechtman, Andrea Cercek, Sumit Middha

Cancer Cell· January 2018

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Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of and as Novel Thyroid Cancer Genes Associated with Tumor Virulence.
Tihana Ibrahimpasic, Bin Xu, Iñigo Landa, Snjezana Dogan, Sumit Middha

Clin Cancer Res· October 2017

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The genetic landscape of endometrial clear cell carcinomas.
Deborah F DeLair, Kathleen A Burke, Pier Selenica, Raymond S Lim, Sasinya N Scott, Sumit Middha

J Pathol· October 2017

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Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes.
Melissa S DeRycke, Shanaka Gunawardena, Jessica R Balcom, Angela M Pickart, Lindsey A Waltman, Sumit Middha

Mol Genet Genomic Med· September 2017

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Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
Ahmet Zehir, Ryma Benayed, Ronak H Shah, Aijazuddin Syed, Sumit Middha

Nat Med· August 2017

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