Publications by authors named "Sundeep Dugar"

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Identification of a common ketohexokinase-dependent link driving alcohol intake and alcohol-associated liver disease in mice.
Ana Andres-Hernando, David J Orlicky, Gabriela E Garcia, Esteban C Loetz, Richard Montoya, Sundeep Dugar

Nat Metab· November 2025

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Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies.
Rebeca Acin-Perez, Cristiane Benincá, Lucia Fernandez Del Rio, Cynthia Shu, Siyouneh Baghdasarian, Sundeep Dugar

EMBO J· May 2023

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Stimulatory effects of (-)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept.
Viridiana Navarrete-Yañez, Alejandra Garate-Carrillo, Marcos Ayala, Antonio Rodriguez-Castañeda, Patricia Mendoza-Lorenzo, Sundeep Dugar

Food Funct· April 2021

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Safety and efficacy of (+)-epicatechin in subjects with Friedreich's ataxia: A phase II, open-label, prospective study.
Muhammad Yasir Qureshi, Marc C Patterson, Vicki Clark, Jonathan N Johnson, Margaret A Moutvic, Sundeep Dugar

J Inherit Metab Dis· March 2021

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(-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy.
Craig M McDonald, Israel Ramirez-Sanchez, Björn Oskarsson, Nanette Joyce, Candace Aguilar, Sundeep Dugar

Muscle Nerve· February 2021

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SPR965, a Dual PI3K/mTOR Inhibitor, as a Targeted Therapy in Ovarian Cancer.
Arthur-Quan Tran, Stephanie A Sullivan, Leo Li-Ying Chan, Yajie Yin, Wenchuan Sun, Sundeep Dugar

Front Oncol· February 2021

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Discovery and Development of SPR519 as a Potent, Selective, and Orally Bioavailable Inhibitor of PI3Kα and mTOR Kinases for the Treatment of Solid Tumors.
Dinesh Mahajan, Somdutta Sen, Bilash Kuila, Amit Sharma, Reena Arora, Sundeep Dugar

J Med Chem· October 2020

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SPR064, a pro-drug of paclitaxel, has anti-tumorigenic effects in endometrial cancer cell lines and mouse models.
Xiaoling Zhao, Weimin Kong, Katherine Tucker, Allison Staley, Yali Fan, Sundeep Dugar

Am J Transl Res· August 2020

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11-β-hydroxysterols as possible endogenous stimulators of mitochondrial biogenesis as inferred from epicatechin molecular mimicry.
Sundeep Dugar, Francisco Villarreal, Frank H Hollinger, Dinesh Mahajan, Israel Ramirez-Sanchez

Pharmacol Res· January 2020

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A pilot study on clinical pharmacokinetics and preclinical pharmacodynamics of (+)-epicatechin on cardiometabolic endpoints.
Aldo Moreno-Ulloa, Nayelli Nájera-García, Marcela Hernández, Israel Ramírez-Sánchez, Pam R Taub, Sundeep Dugar

Food Funct· January 2018

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Killing Glioma 'Stem-like' Cells via Drug-Induced Relocation of Endosomal Urokinase Proteins.
Fredric A Gorin, Nagarekha Pasupuleti, Dinesh Mahajan, Sundeep Dugar

Anticancer Agents Med Chem· June 2017

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A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects.
Gabriela Gutiérrez-Salmeán, Eduardo Meaney, Miguel A Lanaspa, Christina Cicerchi, Richard J Johnson, Sundeep Dugar

Int J Cardiol· November 2016

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Discovery of Novel and Orally Bioavailable Inhibitors of PI3 Kinase Based on Indazole Substituted Morpholino-Triazines.
Sundeep Dugar, Frank P Hollinger, Dinesh Mahajan, Somdutta Sen, Bilash Kuila

ACS Med Chem Lett· December 2015

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Synthesis and evaluation of pyrrolotriazine based molecules as PI3 kinase inhibitors.
Sundeep Dugar, Frank P Hollinger, Bilash Kuila, Reena Arora, Somdutta Sen

Bioorg Med Chem Lett· August 2015

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Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers.
Christopher F Barnett, Aldo Moreno-Ulloa, Sruti Shiva, Israel Ramirez-Sanchez, Pam R Taub, Sundeep Dugar

Food Funct· March 2015

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Outsourcing drug discovery to India and China: from surviving to thriving.
Swaminathan Subramaniam, Sundeep Dugar

Drug Discov Today· October 2012

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Amide-based inhibitors of p38alpha MAP kinase. Part 1: discovery of novel N-pyridyl amide lead molecules.
Gregory R Luedtke, Kurt Schinzel, Xuefei Tan, Richland W Tester, Imad Nashashibi, Sundeep Dugar

Bioorg Med Chem Lett· April 2010

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Amide-based inhibitors of p38alpha MAP kinase. Part 2: design, synthesis and SAR of potent N-pyrimidyl amides.
Richland Tester, Xuefei Tan, Gregory R Luedtke, Imad Nashashibi, Kurt Schinzel, Sundeep Dugar

Bioorg Med Chem Lett· April 2010

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Piperidine-based heterocyclic oxalyl amides as potent p38 alpha MAP kinase inhibitors.
Babu J Mavunkel, John J Perumattam, Xuefei Tan, Gregory R Luedtke, Qing Lu, Sundeep Dugar

Bioorg Med Chem Lett· February 2010

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Design and synthesis of piperazine-indole p38 alpha MAP kinase inhibitors with improved pharmacokinetic profiles.
Xuefei Tan, Richland W Tester, Gregory R Luedtke, Sarvajit Chakravarty, Babu J Mavunkel, Sundeep Dugar

Bioorg Med Chem Lett· February 2010

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p38 MAPK inhibition reduces diabetes-induced impairment of wound healing.
Satyanarayana Medicherla, Scott Wadsworth, Breda Cullen, Derek Silcock, Jing Y Ma, Sundeep Dugar

Diabetes Metab Syndr Obes· June 2009

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Role of p38 mitogen activated protein kinase in a model of osteosarcoma-induced pain.
Camilla I Svensson, Satyanarayana Medicherla, Shelle Malkmus, Yebin Jiang, Jing Y Ma, Sundeep Dugar

Pharmacol Biochem Behav· October 2008

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Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 1: SAR of the aryl region.
Daniel E Levy, Dan-Xiong Wang, Qing Lu, Zheng Chen, John Perumattam, Sundeep Dugar

Bioorg Med Chem Lett· April 2008

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Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 2: SAR of the amine tether.
Daniel E Levy, Dan-Xiong Wang, Qing Lu, Zheng Chen, John Perumattam, Sundeep Dugar

Bioorg Med Chem Lett· April 2008

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Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 3: Importance of the indole orientation.
Qing Lu, Zheng Chen, John Perumattam, Dan-Xiong Wang, Weiling Liang, Sundeep Dugar

Bioorg Med Chem Lett· April 2008

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