Publications by authors named "Susan Gentleman"

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The Amphipathic Helix in Visual Cycle Proteins: A Review.
Sheetal Uppal, Eugenia Poliakov, Susan Gentleman, T Michael Redmond

Adv Exp Med Biol· July 2023

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An inducible amphipathic α-helix mediates subcellular targeting and membrane binding of RPE65.
Sheetal Uppal, Tingting Liu, Emily Galvan, Fatima Gomez, Tishina Tittley, Susan Gentleman

Life Sci Alliance· January 2023

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Xanthophylls Modulate Palmitoylation of Mammalian β-Carotene Oxygenase 2.
Sheetal Uppal, Sergey A Dergunov, Weiyu Zhang, Susan Gentleman, T Michael Redmond

Antioxidants (Basel)· March 2021

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Evolutionary aspects and enzymology of metazoan carotenoid cleavage oxygenases.
Eugenia Poliakov, Sheetal Uppal, Igor B Rogozin, Susan Gentleman, T Michael Redmond

Biochim Biophys Acta Mol Cell Biol Lipids· November 2020

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RPE65 Palmitoylation: A Tale of Lipid Posttranslational Modification.
Sheetal Uppal, Eugenia Poliakov, Susan Gentleman, T Michael Redmond

Adv Exp Med Biol· February 2020

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Utility of In Vitro Mutagenesis of RPE65 Protein for Verification of Mutational Pathogenicity Before Gene Therapy.
Unikora Yang, Susan Gentleman, Xiaowu Gai, Michael B Gorin, Mark S Borchert

JAMA Ophthalmol· December 2019

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The dual roles of RPE65 S-palmitoylation in membrane association and visual cycle function.
Sheetal Uppal, Tingting Liu, Eugenia Poliakov, Susan Gentleman, T Michael Redmond

Sci Rep· March 2019

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Phylogenetic analysis of the metazoan carotenoid oxygenase superfamily: a new ancestral gene assemblage of BCO-like (BCOL) proteins.
Eugenia Poliakov, Joseph Soucy, Susan Gentleman, Igor B Rogozin, T Michael Redmond

Sci Rep· October 2017

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Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism.
Abdulkerim Eroglu, Susan Gentleman, Eugenia Poliakov, T Michael Redmond

J Biol Chem· March 2016

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Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates.
Eugenia Poliakov, Alexander N Gubin, Olivia Stearn, Yan Li, Maria Mercedes Campos, Susan Gentleman

PLoS One· June 2013

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Aromatic residues in the substrate cleft of RPE65 protein govern retinol isomerization and modulate its progression.
Preethi Chander, Susan Gentleman, Eugenia Poliakov, T Michael Redmond

J Biol Chem· August 2012

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The mechanism of fenretinide (4-HPR) inhibition of β-carotene monooxygenase 1. New suspect for the visual side effects of fenretinide.
Eugenia Poliakov, Alexander Gubin, James Laird, Susan Gentleman, Robert G Salomon

Adv Exp Med Biol· April 2012

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Aromatic lipophilic spin traps effectively inhibit RPE65 isomerohydrolase activity.
Eugenia Poliakov, Toral Parikh, Michael Ayele, Stephanie Kuo, Preethi Chander, Susan Gentleman

Biochemistry· August 2011

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RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization.
T Michael Redmond, Eugenia Poliakov, Stephanie Kuo, Preethi Chander, Susan Gentleman

J Biol Chem· January 2010

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Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase.
Eugenia Poliakov, Susan Gentleman, Preethi Chander, Francis X Cunningham, Bella L Grigorenko

BMC Biochem· December 2009

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Effect of Leu/Met variation at residue 450 on isomerase activity and protein expression of RPE65 and its modulation by variation at other residues.
T Michael Redmond, Charles H Weber, Eugenia Poliakov, Shirley Yu, Susan Gentleman

Mol Vis· September 2007

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The level of thymic expression of RPE65 inversely correlates with its capacity to induce experimental autoimmune uveitis (EAU) in different rodent strains.
Don-Il Ham, Chiaki Fujimoto, Susan Gentleman, Chi-Chao Chan, Cheng-Rong Yu

Exp Eye Res· October 2006

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Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.
T Michael Redmond, Eugenia Poliakov, Shirley Yu, Jen-Yue Tsai, Zhongjian Lu, Susan Gentleman

Proc Natl Acad Sci U S A· September 2005

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Key role of conserved histidines in recombinant mouse beta-carotene 15,15'-monooxygenase-1 activity.
Eugenia Poliakov, Susan Gentleman, Francis X Cunningham, Nancy J Miller-Ihli, T Michael Redmond

J Biol Chem· August 2005

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Identification of beta-carotene 15, 15'-monooxygenase as a peroxisome proliferator-activated receptor target gene.
Ana Boulanger, Pamela McLemore, Neal G Copeland, Debra J Gilbert, Nancy A Jenkins, Susan Gentleman

FASEB J· July 2003

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Expression of beta-carotene 15,15' monooxygenase in retina and RPE-choroid.
Rizwan A Bhatti, Shirley Yu, Ana Boulanger, Robert N Fariss, Yan Guo, Susan Gentleman

Invest Ophthalmol Vis Sci· January 2003

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RPE65 is highly uveitogenic in rats.
Don-Il Ham, Susan Gentleman, Chi-Chao Chan, J Hugh McDowell, T Michael Redmond

Invest Ophthalmol Vis Sci· July 2002

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