Publications by authors named "Susan Kaech"

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Dietary restriction reprograms CD8 T cell fate to enhance anti-tumour immunity and immunotherapy responses.
Brandon M Oswald, Lisa M DeCamp, Joseph Longo, Michael S Dahabieh, Nicholas Bunda, Susan Kaech

Nat Metab· December 2025

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EVOLVE platform, a trispecific T cell engager with integrated CD2 costimulation, for the treatment of solid and hematologic tumors.
Oksana A Sergeeva, Guixian Jin, Mohosin Sarkar, Jennifer Zeiger, Sonali Dhindwal, Susan M Kaech

Proc Natl Acad Sci U S A· November 2025

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Guidelines for T cell nomenclature.
David Masopust, Amit Awasthi, Rémy Bosselut, David G Brooks, Marcus Buggert, Susan M Kaech

Nat Rev Immunol· November 2025

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The antiviral Interferon pathway drives astrocyte aging and motor decline.
Lara Labarta-Bajo, Ayesha R Thanawalla, Irene L Gutierrez, Su May Lei Soe, Brent Y Chick, Susan M Kaech

bioRxiv· November 2025

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Retraction Notice to "Aberrant CD8 T-Cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 Signaling" [Am J Pathol 178 (2011) 2740-2751].
Anthony D D'Souza, Ian A Parish, Sharen E McKay, Susan M Kaech, Gerald S Shadel

Am J Pathol· October 2025

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Efficacious suppression of primary and metastasized liver tumors by polyIC-loaded lipid nanoparticles.
Yingluo Liu, Xinyi Wang, Nishta Krishnan, Timothy Hsiao, Yichun Ji, Susan M Kaech

Hepatology· September 2025

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p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells.
Karl N Miller, Brightany Li, Hannah R Pierce-Hoffman, Shreeya Patel, Xue Lei, Susan M Kaech

Nat Commun· March 2025

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Scavenger Receptor CD36 in Tumor-Associated Macrophages Promotes Cancer Progression by Dampening Type-I IFN Signaling.
Ziyan Xu, Alexandra Kuhlmann-Hogan, Shihao Xu, Hubert Tseng, Dan Chen, Susan M Kaech

Cancer Res· February 2025

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Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma.
Meaghan K McGeary, William Damsky, Andrew J Daniels, Sabine M Lang, Qingji Xu, Susan M Kaech

Cancer Immunol Res· February 2025

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Nutrient-driven histone code determines exhausted CD8 T cell fates.
Shixin Ma, Michael S Dahabieh, Thomas H Mann, Steven Zhao, Bryan McDonald, Susan M Kaech

Science· February 2025

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Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer.
Camila Robles-Oteíza, Katherine Hastings, Jungmin Choi, Isabelle Sirois, Arvind Ravi, Susan M Kaech

J Exp Med· January 2025

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Bile acid synthesis impedes tumor-specific T cell responses during liver cancer.
Siva Karthik Varanasi, Dan Chen, Yingluo Liu, Melissa A Johnson, Cayla M Miller, Susan M Kaech

Science· January 2025

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Dietary Restriction Enhances CD8 T Cell Ketolysis to Limit Exhaustion and Boost Anti-Tumor Immunity.
Brandon M Oswald, Lisa M DeCamp, Joseph Longo, Michael S Dahabieh, Nicholas Bunda, Susan Kaech

bioRxiv· November 2024

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Transcriptional repression by HDAC3 mediates T cell exclusion from mutant lung tumors.
Caroline K McGuire, Ambryn S Meehan, Evan Couser, Lois Bull, Allegra C Minor, Susan M Kaech

Proc Natl Acad Sci U S A· October 2024

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Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistance.
Kate Bridges, Gabriela A Pizzurro, Alev Baysoy, Janani P Baskaran, Ziyan Xu, Susan M Kaech

bioRxiv· October 2024

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Linked regulation of genome integrity and senescence-associated inflammation by p53.
Karl N Miller, Brightany Li, Hannah R Pierce-Hoffman, Shreeya Patel, Xue Lei, Susan M Kaech

bioRxiv· September 2024

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ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses.
Irem Kaymak, McLane J Watson, Brandon M Oswald, Shixin Ma, Benjamin K Johnson, Susan M Kaech

J Exp Med· September 2024

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Linoleoyl-lysophosphatidylcholine suppresses immune-related adverse events due to immune checkpoint blockade.
Ian T Mathews, Priyanka Saminathan, Mir Henglin, Mingyue Liu, Namratha Nadig, Susan M Kaech

medRxiv· August 2024

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ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity.
Matthew B Maxwell, Marianne S Hom-Tedla, Jawoon Yi, Shitian Li, Samuel A Rivera, Susan M Kaech

Cell· June 2024

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EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth.
Alexandra Kuhlmann-Hogan, Thekla Cordes, Ziyan Xu, Ramya S Kuna, Kacie A Traina, Susan M Kaech

Cancer Discov· January 2024

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EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth.
Alexandra Kuhlmann-Hogan, Thekla Cordes, Ziyan Xu, Ramya S Kuna, Kacie A Traina, Susan M Kaech

Cancer Discov· January 2024

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Early Chromatin Remodeling Events in Acutely Stimulated CD8 T Cells.
Bryan McDonald, Brent Y Chick, Diana C Hargreaves, Susan M Kaech

Yale J Biol Med· December 2023

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A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better.
Dijana Djureinovic, Sarah A Weiss, Irina Krykbaeva, Rihao Qu, Ioannis Vathiotis, Susan M Kaech

Mol Cancer· November 2023

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CD8 T cells in the cancer-immunity cycle.
Josephine R Giles, Anna-Maria Globig, Susan M Kaech, E John Wherry

Immunity· October 2023

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