Publications by authors named "Sven Mathias"

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Loss of a newly discovered microRNA in Chinese hamster ovary cells leads to upregulation of N-glycolylneuraminic acid sialylation on monoclonal antibodies.
Simon Fischer, Sven Mathias, Anna Stadermann, Shumin Yang, Valerie Schmieder

Biotechnol Bioeng· March 2022

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A blueprint from nature: miRNome comparison of plasma cells and CHO cells to optimize therapeutic antibody production.
Nadja Raab, Nikolas Zeh, Patrick Schlossbauer, Sven Mathias, Benjamin Lindner

N Biotechnol· January 2022

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Unveiling the CHO surfaceome: Identification of cell surface proteins reveals cell aggregation-relevant mechanisms.
Florian Klingler, Sven Mathias, Helga Schneider, Theresa Buck, Nadja Raab

Biotechnol Bioeng· August 2021

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Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain.
Joschka Bauer, Sven Mathias, Sebastian Kube, Kerstin Otte, Patrick Garidel

MAbs· July 2021

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Human CAP cells represent a novel source for functional, miRNA-loaded exosome production.
Nikolas Zeh, Helga Schneider, Sven Mathias, Nadja Raab, Michael Kleemann

PLoS One· March 2020

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Unraveling what makes a monoclonal antibody difficult-to-express: From intracellular accumulation to incomplete folding and degradation via ERAD.
Sven Mathias, Anna Wippermann, Nadja Raab, Nikolas Zeh, René Handrick

Biotechnol Bioeng· January 2020

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CRISPR/Cas9-Mediated Knockout of MicroRNA-744 Improves Antibody Titer of CHO Production Cell Lines.
Nadja Raab, Sven Mathias, Kerstin Alt, René Handrick, Simon Fischer

Biotechnol J· May 2019

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Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy.
Sven Mathias, Simon Fischer, René Handrick, Jürgen Fieder, Patrick Schulz

J Biotechnol· April 2018

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miR-2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality.
Simon Fischer, Albert Jesuran Paul, Andreas Wagner, Sven Mathias, Melanie Geiss

Biotechnol Bioeng· October 2015

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Enhanced protein production by microRNA-30 family in CHO cells is mediated by the modulation of the ubiquitin pathway.
Simon Fischer, Sven Mathias, Simone Schaz, Verena Vanessa Emmerling, Theresa Buck

J Biotechnol· October 2015

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A functional high-content miRNA screen identifies miR-30 family to boost recombinant protein production in CHO cells.
Simon Fischer, Theresa Buck, Andreas Wagner, Carolin Ehrhart, Julia Giancaterino, Sven Mathias

Biotechnol J· October 2014

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