Publications by authors named "Rene Handrick"

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Stable overexpression of native and artificial miRNAs for the production of differentially fucosylated antibodies in CHO cells.
Patrick Schlossbauer, Lukas Naumann, Florian Klingler, Madina Burkhart, René Handrick

Eng Life Sci· June 2024

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Developing microRNAs as engineering tools to modulate monoclonal antibody galactosylation.
Florian Klingler, Patrick Schlossbauer, Lukas Naumann, René Handrick, Friedemann Hesse

Biotechnol Bioeng· April 2024

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A novel system for glycosylation engineering by natural and artificial miRNAs.
Florian Klingler, Lukas Naumann, Patrick Schlossbauer, Leonard Dreyer, Madina Burkhart, René Handrick

Metab Eng· May 2023

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Exploring synthetic biology for the development of a sensor cell line for automated bioprocess control.
Nikolas Zeh, Melina Bräuer, Nadja Raab, René Handrick, Kerstin Otte

Sci Rep· February 2022

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A blueprint from nature: miRNome comparison of plasma cells and CHO cells to optimize therapeutic antibody production.
Nadja Raab, Nikolas Zeh, Patrick Schlossbauer, Sven Mathias, Benjamin Lindner, René Handrick

N Biotechnol· January 2022

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Cell line development for continuous high cell density biomanufacturing: Exploiting hypoxia for improved productivity.
Nikolas Zeh, Patrick Schlossbauer, Nadja Raab, Florian Klingler, René Handrick

Metab Eng Commun· December 2021

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Refolding and characterization of two G protein-coupled receptors purified from E. coli inclusion bodies.
Bastian Heim, René Handrick, Marcus D Hartmann, Hans Kiefer

PLoS One· August 2021

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mir-124-5p Regulates Phagocytosis of Human Macrophages by Targeting the Actin Cytoskeleton via the ARP2/3 Complex.
Estefania Herdoiza Padilla, Peter Crauwels, Tim Bergner, Nicole Wiederspohn, Sabrina Förstner, René Handrick

Front Immunol· November 2020

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Human CAP cells represent a novel source for functional, miRNA-loaded exosome production.
Nikolas Zeh, Helga Schneider, Sven Mathias, Nadja Raab, Michael Kleemann, René Handrick

PLoS One· March 2020

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Unraveling what makes a monoclonal antibody difficult-to-express: From intracellular accumulation to incomplete folding and degradation via ERAD.
Sven Mathias, Anna Wippermann, Nadja Raab, Nikolas Zeh, René Handrick

Biotechnol Bioeng· January 2020

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Infrared attenuated total reflection and 2D fluorescence spectroscopy for the discrimination of differently aggregated monoclonal antibodies.
Alina Handl, Ángela I López-Lorente, René Handrick, Boris Mizaikoff, Friedemann Hesse

Analyst· October 2019

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CRISPR/Cas9-Mediated Knockout of MicroRNA-744 Improves Antibody Titer of CHO Production Cell Lines.
Nadja Raab, Sven Mathias, Kerstin Alt, René Handrick, Simon Fischer

Biotechnol J· May 2019

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A simple dual-inducible CRISPR interference system for multiple gene targeting in Corynebacterium glutamicum.
Rahul Gauttam, Gerd M Seibold, Phillipp Mueller, Tatjana Weil, Tamara Weiß, René Handrick

Plasmid· May 2019

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Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5.
Michael Kleemann, Helga Schneider, Kristian Unger, Jeremias Bereuther, Simon Fischer, René Handrick

Cell Mol Life Sci· February 2019

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High level in vivo mucin-type glycosylation in Escherichia coli.
Phillipp Mueller, Rahul Gauttam, Nadja Raab, René Handrick, Claudia Wahl

Microb Cell Fact· October 2018

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Stable miRNA overexpression in human CAP cells: Engineering alternative production systems for advanced manufacturing of biologics using miR-136 and miR-3074.
Benjamin L Weis, Nadine Guth, Simon Fischer, Silke Wissing, Simon Fradin, René Handrick

Biotechnol Bioeng· August 2018

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miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells.
Marion Flum, Michael Kleemann, Helga Schneider, Benjamin Weis, Simon Fischer, René Handrick

J Cell Commun Signal· June 2018

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MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells.
Michael Kleemann, Helga Schneider, Kristian Unger, Philip Sander, E Marion Schneider, René Handrick

Sci Rep· June 2018

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Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.
Albert J Paul, René Handrick, Sybille Ebert, Friedemann Hesse

Biotechnol Bioeng· May 2018

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Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy.
Sven Mathias, Simon Fischer, René Handrick, Jürgen Fieder, Patrick Schulz

J Biotechnol· April 2018

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miR-143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult-to-express proteins.
Melanie Schoellhorn, Simon Fischer, Andreas Wagner, René Handrick, Kerstin Otte

Biotechnol Prog· July 2017

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High-throughput analysis of sub-visible mAb aggregate particles using automated fluorescence microscopy imaging.
Albert Jesuran Paul, Fabian Bickel, Martina Röhm, Lisa Hospach, Bettina Halder, René Handrick

Anal Bioanal Chem· July 2017

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Investigation on tissue specific effects of pro-apoptotic micro RNAs revealed miR-147b as a potential biomarker in ovarian cancer prognosis.
Michael Kleemann, Jeremias Bereuther, Simon Fischer, Kim Marquart, Simon Hänle, René Handrick

Oncotarget· March 2017

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Exploring the capabilities of fluorometric online monitoring on chinese hamster ovary cell cultivations producing a monoclonal antibody.
Karen Schwab, Thomas Amann, Jakob Schmid, René Handrick, Friedemann Hesse

Biotechnol Prog· November 2016

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miR-483 is a self-regulating microRNA and can activate its own expression via USF1 in HeLa cells.
Verena Vanessa Emmerling, Simon Fischer, Michael Kleemann, René Handrick, Stefan Kochanek

Int J Biochem Cell Biol· November 2016

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