Publications by authors named "Swapnil C Devarkar"

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Distinct Target Site of Lenacapavir in Immature HIV-1 and Concurrent Binding with the Maturation Inhibitor Bevirimat.
Chunxiang Wu, Megan E Meuser, Juan S Rey, Hamed Meshkin, Rachel Yang, Swapnil C Devarkar

J Am Chem Soc· November 2025

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Visualizing the translation landscape in human cells at high resolution.
Wei Zheng, Yuekang Zhang, Jimin Wang, Shuhui Wang, Pengxin Chai, Swapnil C Devarkar

Nat Commun· November 2025

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Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation.
Brigitte S Naughton, Swapnil C Devarkar, Vanessa Todorow, Sunanda Mallik, Stacey Oxendine

J Cell Biol· September 2025

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Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells.
Klarissa Hollander, Swapnil C Devarkar, Su Tang, Ritudhwaj Tiwari, Shumeng Ma

NPJ Drug Discov· September 2025

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Structural basis for aminoacylation of cellular modified tRNALys3 by human lysyl-tRNA synthetase.
Swapnil C Devarkar, Christina R Budding, Chathuri Pathirage, Arundhati Kavoor, Cassandra Herbert

Nucleic Acids Res· February 2025

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Practical Guide for Implementing Cryogenic Electron Microscopy Structure Determination in Dermatology Research.
Ivan B Lomakin, Swapnil C Devarkar, Christian Freniere, Christopher G Bunick

J Invest Dermatol· January 2025

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Structural basis for aminoacylation of cellular modified tRNA by human lysyl-tRNA synthetase.
Swapnil C Devarkar, Christina R Budding, Chathuri Pathirage, Arundhati Kavoor, Cassandra Herbert

bioRxiv· December 2024

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Mechanistic Basis for the Translation Inhibition of Cutibacterium acnes by Clindamycin.
Ivan B Lomakin, Swapnil C Devarkar, Ayman Grada, Christopher G Bunick

J Invest Dermatol· November 2024

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Structural insights into inhibitor mechanisms on immature HIV-1 Gag lattice revealed by high-resolution single-particle cryo-EM.
Chunxiang Wu, Megan E Meuser, Juan S Rey, Hamed Meshkin, Rachel Yang, Swapnil Chandrakant Devarkar

bioRxiv· October 2024

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Visualizing the translation landscape in human cells at high resolution.
Wei Zheng, Yuekang Zhang, Jimin Wang, Shuhui Wang, Pengxin Chai, Swapnil C Devarkar

bioRxiv· July 2024

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Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses.
Swapnil C Devarkar, Michael Vetick, Shravani Balaji, Ivan B Lomakin, Luojia Yang

Cell Rep· October 2023

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RIG-I recognizes metabolite-capped RNAs as signaling ligands.
Brandon D Schweibenz, Mihai Solotchi, Pranita Hanpude, Swapnil C Devarkar, Smita S Patel

Nucleic Acids Res· August 2023

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Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Ivan B Lomakin, Swapnil C Devarkar, Shivali Patel, Ayman Grada, Christopher G Bunick

Nucleic Acids Res· April 2023

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The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores.
Qi Shen, Sushila Kumari, Chaoyi Xu, Sooin Jang, Jiong Shi, Swapnil C Devarkar

Proc Natl Acad Sci U S A· March 2023

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Structures of a mobile intron retroelement poised to attack its structured DNA target.
Kevin Chung, Ling Xu, Pengxin Chai, Junhui Peng, Swapnil C Devarkar

Science· November 2022

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The intrinsically disordered CARDs-Helicase linker in RIG-I is a molecular gate for RNA proofreading.
Brandon D Schweibenz, Swapnil C Devarkar, Mihai Solotchi, Candice Craig, Jie Zheng

EMBO J· May 2022

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Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology.
Catherine Amaya, Christopher J F Cameron, Swapnil C Devarkar, Sebastian J H Seager, Mark B Gerstein

J Biol Chem· August 2021

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Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA.
Shuai Yuan, Lei Peng, Jonathan J Park, Yingxia Hu, Swapnil C Devarkar

Mol Cell· December 2020

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APOBEC3A Loop 1 Is a Determinant for Single-Stranded DNA Binding and Deamination.
Samantha J Ziegler, Yingxia Hu, Swapnil C Devarkar, Yong Xiong

Biochemistry· September 2019

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HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.
Jie Zheng, Chen Wang, Mi Ra Chang, Swapnil C Devarkar, Brandon Schweibenz

Nat Commun· December 2018

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RIG-I Uses an ATPase-Powered Translocation-Throttling Mechanism for Kinetic Proofreading of RNAs and Oligomerization.
Swapnil C Devarkar, Brandon Schweibenz, Chen Wang, Joseph Marcotrigiano, Smita S Patel

Mol Cell· October 2018

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The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection.
Anand Ramanathan, Swapnil C Devarkar, Fuguo Jiang, Matthew T Miller, Abdul G Khan

Nucleic Acids Res· January 2016

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Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Swapnil C Devarkar, Chen Wang, Matthew T Miller, Anand Ramanathan, Fuguo Jiang

Proc Natl Acad Sci U S A· January 2016

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