Publications by authors named "Tai Lin"

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Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma.
Margaret A Potts, Shinsuke Mizutani, Yexuan Deng, Srimayee Vaidyanathan, Keziah E Ting, Lin Tai

Nat Commun· August 2025

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Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation.
Erin M Lawrence, Amali Cooray, Andrew J Kueh, Martin Pal, Lin Tai

EMBO Rep· June 2025

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Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening.
Wei Jin, Yexuan Deng, John E La Marca, Emily J Lelliott, Sarah T Diepstraten, Lin Tai

Nat Commun· January 2025

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Mouse models to investigate in situ cell fate decisions induced by p53.
Elizabeth Lieschke, Annabella F Thomas, Andrew Kueh, Georgia K Atkin-Smith, Pedro L Baldoni, Aisling M Ross, Lin Tai

EMBO J· October 2024

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Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells.
Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant, Tao Tan, Lin Tai

Cancer Discov· February 2024

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Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses.
John E La Marca, Brandon J Aubrey, Bruce Yang, Catherine Chang, Zilu Wang, Lin Tai

Cell Death Differ· February 2024

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Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis.
Margaret A Potts, Shinsuke Mizutani, Alexandra L Garnham, Connie S N Li Wai Suen, Andrew J Kueh, Lin Tai

Cell Death Differ· June 2023

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Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance.
Yexuan Deng, Sarah T Diepstraten, Margaret A Potts, Göknur Giner, Stephanie Trezise, Lin Tai

Nat Commun· August 2022

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Author Correction: Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance.
Yexuan Deng, Sarah T Diepstraten, Margaret A Potts, Göknur Giner, Stephanie Trezise, Lin Tai

Nat Commun· August 2022

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Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs.
Lahiru Gangoda, Robyn L Schenk, Lin Tai, Pacman Szeto, Jen G Cheung

Cell Death Dis· April 2022

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The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival.
Pasquale L Fedele, Yang Liao, Jia-Nan Gong, Yuan Yao, Mark F van Delft, Lin Tai

Leukemia· July 2021

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Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias.
Rachel Thijssen, Sarah T Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Lin Tai

Blood· May 2021

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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.
Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Lin Tai

Immunity· September 2020

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Systematic identification of dysregulated lncRNAs associated with platinum-based chemotherapy response across 11 cancer types.
Yanjiao Zhu, Yichuan Zhao, Siyao Dong, Lu Liu, Lin Tai

Genomics· March 2020

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Characterization of a novel human BFL-1-specific monoclonal antibody.
Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden, Lin Tai

Cell Death Differ· February 2020

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BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines.
Sarah T Diepstraten, Catherine Chang, Lin Tai, Jia-Nan Gong, Ping Lan

Blood Adv· January 2020

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Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.
Alex R D Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Lin Tai

Cell Rep· April 2019

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Surface-enhanced Raman spectroscopic analysis of N-benzylaminopurine residue quantity in sprouts with gold nanoparticles.
Ping Zhang, Li M Wang, Da W Zheng, Tai F Lin, Xiao D Wei

J Environ Sci Health B· March 2019

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Humanized mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use.
Margs S Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas Strasser

Blood· October 2018

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DNA repair processes are critical mediators of p53-dependent tumor suppression.
Ana Janic, Liz J Valente, Matthew J Wakefield, Leon Di Stefano, Liz Milla, Lin Tai, Lisa M Lindqvist

Nat Med· July 2018

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Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.
Lorraine A O'Reilly, Tracy L Putoczki, Lisa A Mielke, Jun T Low, Ann Lin, Lin Tai

Immunity· March 2018

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An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles.
Andrew J Kueh, Martin Pal, Lin Tai, Yang Liao, Gordon K Smyth

Cell Death Differ· October 2017

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Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.
Robyn L Schenk, Selma Tuzlak, Emma M Carrington, Yifan Zhan, Susanne Heinzel, Lin Tai

Cell Death Differ· March 2017

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Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.
Leona Rohrbeck, Jia-Nan Gong, Erinna F Lee, Andrew J Kueh, Andreas Behren, Lin Tai

Cell Death Differ· December 2016

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RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.
Alex R D Delbridge, Swee Heng Milon Pang, Cassandra J Vandenberg, Stephanie Grabow, Brandon J Aubrey, Lin Tai

J Exp Med· September 2016

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