Publications by authors named "Guillaume Lessene"

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Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity.
Xinyu Wu, Shane M Devine, Margareta Go, Julie V Nguyen, Bernadine G C Lu, Guillaume Lessene

PLoS Pathog· September 2025

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Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins.
Jia-Nan Gong, Tirta M Djajawi, Donia M Moujalled, Giovanna Pomilio, Tiffany Khong, Guillaume Lessene

Cell Death Differ· August 2025

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A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.
Stefanie M Bader, Dale J Calleja, Shane M Devine, Nathan W Kuchel, Bernadine G C Lu, Guillaume Lessene

Nat Commun· April 2025

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Differential regulation of BAX and BAK apoptotic activity revealed by small molecules.
Kaiming Li, Yu Q Yap, Donia M Moujalled, Fransisca Sumardy, Yelena Khakham, Guillaume Lessene

Sci Adv· March 2025

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Improved drug target deconvolution with PISA-DIA using an extended, overlapping temperature gradient.
Samantha J Emery-Corbin, Jumana M Yousef, Subash Adhikari, Fransisca Sumardy, Duong Nhu, Guillaume Lessene

Proteomics· August 2024

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Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape.
Xinyu Wu, Margareta Go, Julie V Nguyen, Nathan W Kuchel, Bernadine G C Lu, Guillaume Lessene

Nat Commun· July 2024

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Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.
Zheng Yuan, Mark F van Delft, Mark Xiang Li, Fransisca Sumardy, Brian J Smith, Guillaume Lessene

PLoS Biol· May 2024

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Correction: ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors Across Tumor Types.
Anderly C Chüeh, Janson W T Tse, Michael Dickinson, Paul Ioannidis, Laura Jenkins, Guillaume Lessene

Clin Cancer Res· September 2023

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The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase.
Catia L Pierotti, Annette V Jacobsen, Christoph Grohmann, Ruby K Dempsey, Nima Etemadi, Guillaume Lessene

Biochem J· May 2023

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The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Guillaume Lessene

Cell Death Differ· April 2023

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Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Guillaume Lessene

Cell Death Differ· April 2023

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Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.
Donia M Moujalled, Fiona C Brown, Chong Chyn Chua, Michael A Dengler, Giovanna Pomilio, Guillaume Lessene

Blood· February 2023

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From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors.
Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, Guillaume Lessene

J Med Chem· February 2023

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Dual drug targeting to kill colon cancers.
Silvia Paola Corona, Francesca Walker, Janet Weinstock, Guillaume Lessene, Maree Faux

Cancer Med· July 2022

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BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells.
Diane Moujalled, Adam G Southon, Eiman Saleh, Kerstin Brinkmann, Francine Ke, Guillaume Lessene

Cell Death Differ· July 2022

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The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
Annette V Jacobsen, Catia L Pierotti, Kym N Lowes, Amanda E Au, Ying Zhang, Guillaume Lessene

Cell Death Dis· April 2022

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Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs.
Lahiru Gangoda, Robyn L Schenk, Lin Tai, Pacman Szeto, Jen G Cheung, Guillaume Lessene

Cell Death Dis· April 2022

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Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.
Christoph Grohmann, Charlene M Magtoto, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Guillaume Lessene

Nat Commun· April 2022

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Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors.
Dale J Calleja, Nathan Kuchel, Bernadine G C Lu, Richard W Birkinshaw, Theresa Klemm, Guillaume Lessene

Front Chem· April 2022

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Inhibitors of SARS-CoV-2 PLpro.
Dale J Calleja, Guillaume Lessene, David Komander

Front Chem· April 2022

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The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs.
Sarah T Diepstraten, Mary Ann Anderson, Peter E Czabotar, Guillaume Lessene, Andreas Strasser

Nat Rev Cancer· January 2022

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Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Yanxiang Meng, Katherine A Davies, Cheree Fitzgibbon, Samuel N Young, Sarah E Garnish, Guillaume Lessene

Nat Commun· November 2021

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BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia.
Emma M Carrington, Cynthia Louis, Tobias Kratina, Manuela Hancock, Christine R Keenan, Guillaume Lessene

Blood Adv· June 2021

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Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X and BCL-2.
Michael J Roy, Amelia Vom, Toru Okamoto, Brian J Smith, Richard W Birkinshaw, Guillaume Lessene

J Med Chem· May 2021

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Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.
Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C Chüeh, Guillaume Lessene

Cell Death Dis· March 2021

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