Publications by authors named "Tatos Akopian"

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Author Correction: Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development.
Katharina Weinhäupl, Louis Meuret, Sandy Desrat, Fanny Roussi, Nelly Morellet, Tatos Akopian

Sci Rep· March 2025

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Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development.
Katharina Weinhäupl, Louis Meuret, Sandy Desrat, Fanny Roussi, Nelly Morellet, Tatos Akopian

Sci Rep· February 2025

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Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy.
Harim I Won, Samuel Zinga, Olga Kandror, Tatos Akopian, Ian D Wolf

Nat Commun· May 2024

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Correction: Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.
Katharina Weinhäupl, Marcos Gragera, M Teresa Bueno-Carrasco, Rocío Arranz, Olga Krandor, Tatos Akopian

J Biol Chem· July 2023

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Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.
Katharina Weinhäupl, Marcos Gragera, M Teresa Bueno-Carrasco, Rocío Arranz, Olga Krandor, Tatos Akopian

J Biol Chem· November 2022

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ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.
Jemila C Kester, Olga Kandror, Tatos Akopian, Michael R Chase, Junhao Zhu

J Bacteriol· January 2021

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Pyrazinamide triggers degradation of its target aspartate decarboxylase.
Pooja Gopal, Jickky Palmae Sarathy, Michelle Yee, Priya Ragunathan, Joon Shin, Tatos Akopian

Nat Commun· April 2020

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Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis.
Hugo Fraga, Beatriz Rodriguez, Ana Bardera, Concha Cid, Tatos Akopian

Anal Biochem· February 2019

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An Antibacterial β-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis.
Johannes Lehmann, Tan-Yun Cheng, Anup Aggarwal, Annie S Park, Evelyn Zeiler, Tatos Akopian

Angew Chem Int Ed Engl· January 2018

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Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.
Kirsten Famulla, Peter Sass, Imran Malik, Tatos Akopian, Olga Kandror

Mol Microbiol· July 2016

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Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.
Mi Li, Olga Kandror, Tatos Akopian, Poorva Dharkar, Alexander Wlodawer

J Biol Chem· April 2016

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Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity.
Tatos Akopian, Olga Kandror, Christopher Tsu, Jack H Lai, Wengen Wu

J Biol Chem· April 2015

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The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo.
Wei Gao, Jin-Yong Kim, Jeffrey R Anderson, Tatos Akopian, Seungpyo Hong

Antimicrob Agents Chemother· February 2015

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Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
Ekaterina Gavrish, Clarissa S Sit, Shugeng Cao, Olga Kandror, Amy Spoering, Tatos Akopian

Chem Biol· April 2014

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The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.
Tatos Akopian, Olga Kandror, Ravikiran M Raju, Meera Unnikrishnan, Eric J Rubin

EMBO J· March 2012

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Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection.
Ravikiran M Raju, Meera Unnikrishnan, Daniel H F Rubin, Vidhya Krishnamoorthy, Olga Kandror, Tatos N Akopian

PLoS Pathog· February 2012

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A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis.
Kristie Grove Bridges, Rajiv Chopra, Laura Lin, Kristine Svenson, Amy Tam, Tatos N Akopian

Peptides· July 2006

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Structure-based design of estrogen receptor-beta selective ligands.
Eric S Manas, Rayomand J Unwalla, Zhang B Xu, Michael S Malamas, Chris P Miller, Tatos Akopian

J Am Chem Soc· November 2004

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