Publications by authors named "Ted Simon"

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Calibration and evaluation of a refined pharmacokinetic model for three homologs of phosphatidylethanol.
Ted W Simon, Brett Ginsburg, Martin A Javors, Nathalie Hill-Kapturczak, Marisa Lopez-Crusan

Chem Biol Interact· February 2025

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The 2022 revised WHO TEFs for dioxins and dioxin-like chemicals: The importance of considering the use of species-specific information to determine relative effective potency for human-based risk assessment.
David L Eaton, Ted W Simon, Norbert E Kaminski, Gary H Perdew, Daniel W Nebert

Regul Toxicol Pharmacol· May 2024

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Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors.
David L Eaton, Ted W Simon, Norbert E Kaminski, Gary H Perdew, Daniel W Nebert

Regul Toxicol Pharmacol· May 2024

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Commentary: Value of information case study strongly supports use of the Threshold of Toxicological Concern (TTC).
Ted W Simon, Jessica Ryman, Richard A Becker

Regul Toxicol Pharmacol· May 2024

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Letter to the Editor: Modeling the changing face of Phosphatidylethanol's window of detection.
Van Long Nguyen, Ted W Simon

Regul Toxicol Pharmacol· January 2024

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Providing context for phosphatidylethanol as a biomarker of alcohol consumption with a pharmacokinetic model.
Ted W Simon

Regul Toxicol Pharmacol· April 2018

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In vitro to in vivo extrapolation for high throughput prioritization and decision making.
Shannon M Bell, Xiaoqing Chang, John F Wambaugh, David G Allen, Mike Bartels, Ted W Simon

Toxicol In Vitro· March 2018

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Utilizing Threshold of Toxicological Concern (TTC) with High Throughput Exposure Predictions (HTE) as a Risk-Based Prioritization Approach for thousands of chemicals.
Grace Patlewicz, John F Wambaugh, Susan P Felter, Ted W Simon, Richard A Becker

Comput Toxicol· January 2018

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How well can carcinogenicity be predicted by high throughput "characteristics of carcinogens" mechanistic data?
Richard A Becker, David A Dreier, Mary K Manibusan, Louis A Tony Cox, Ted W Simon

Regul Toxicol Pharmacol· November 2017

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Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study.
Nancy B Beck, Richard A Becker, Neeraja Erraguntla, William H Farland, Roberta L Grant, Ted Simon

Environ Int· November 2016

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Bayesian methods for uncertainty factor application for derivation of reference values.
Ted W Simon, Yiliang Zhu, Michael L Dourson, Nancy B Beck

Regul Toxicol Pharmacol· October 2016

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A model for aryl hydrocarbon receptor-activated gene expression shows potency and efficacy changes and predicts squelching due to competition for transcription co-activators.
Ted W Simon, Robert A Budinsky, J Craig Rowlands

PLoS One· May 2016

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The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor.
Richard A Becker, Grace Patlewicz, Ted W Simon, J Craig Rowlands, Robert A Budinsky

Regul Toxicol Pharmacol· October 2015

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An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity--proof of concept.
Richard A Becker, Katie Paul Friedman, Ted W Simon, M Sue Marty, Grace Patlewicz

Regul Toxicol Pharmacol· April 2015

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Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes.
Grace Patlewicz, Ted W Simon, J Craig Rowlands, Robert A Budinsky, Richard A Becker

Regul Toxicol Pharmacol· April 2015

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The use of mode of action information in risk assessment: quantitative key events/dose-response framework for modeling the dose-response for key events.
Ted W Simon, S Stoney Simons, R Julian Preston, Alan R Boobis, Samuel M Cohen

Crit Rev Toxicol· August 2014

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Evidence-based toxicology for the 21st century: opportunities and challenges.
Martin L Stephens, Melvin Andersen, Richard A Becker, Kellyn Betts, Kim Boekelheide, Ted Simon

ALTEX· July 2013

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Use and validation of HT/HC assays to support 21st century toxicity evaluations.
Grace Patlewicz, Ted Simon, Katy Goyak, Richard D Phillips, J Craig Rowlands

Regul Toxicol Pharmacol· March 2013

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Just who is at risk? The ethics of environmental regulation.
Ted Simon

Hum Exp Toxicol· August 2011

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Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.
Robert A Budinsky, Edward L LeCluyse, Stephen S Ferguson, J Craig Rowlands, Ted Simon

Toxicol Sci· November 2010

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Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p)dioxin using linear and nonlinear dose-response modeling and toxicokinetics.
Ted Simon, Lesa L Aylward, Christopher R Kirman, J Craig Rowlands, Robert A Budinsky

Toxicol Sci· December 2009

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Estimates of cancer potency of 2,3,4,7,8-pentachlorodibenzofuran using both nonlinear and linear approaches.
Ted Simon, Christopher R Kirman, Lesa L Aylward, Robert A Budinsky, J Craig Rowlands

Toxicol Sci· December 2008

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Development of a neurotoxic equivalence scheme of relative potency for assessing the risk of PCB mixtures.
Ted Simon, Janice K Britt, Robert C James

Regul Toxicol Pharmacol· July 2007

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Development of a reference dose for the persistent congeners of weathered toxaphene based on in vivo and in vitro effects related to tumor promotion.
Ted Simon, Randall Manning

Regul Toxicol Pharmacol· April 2006

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