Publications by authors named "Teemu Haikarainen"

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Investigation of the transcriptional impact of rare germline JAK/STAT variants found in a Tyrolean alpine community.
Lothar Hennighausen, Teemu Haikarainen, Sung-Gwon Lee, Yasemin Caf, Priscilla A Furth

BMC Genomics· December 2025

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Coxsackie B1 virus-like particle vaccine modified to exclude a highly conserved immunoreactive region from the capsid induces potent neutralizing antibodies and protects against infection in mice.
Saana Soppela, Martín González-Rodríguez, Virginia M Stone, Iiris Mustonen, Niila V V Jouppila, Teemu Haikarainen

J Biomed Sci· September 2025

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Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target.
Anniina Virtanen, Vivian Kettunen, Kirsikka Musta, Veera Räkköläinen, Stefan Knapp, Teemu Haikarainen

Adv Biol Regul· January 2025

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Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity.
Ya Miao, Anniina Virtanen, Jakub Zmajkovic, Morgane Hilpert, Radek C Skoda, Teemu Haikarainen

J Med Chem· June 2024

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Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling.
Bobin George Abraham, Teemu Haikarainen, Joni Vuorio, Mykhailo Girych, Anniina T Virtanen

Sci Adv· March 2024

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Differences in JAK Isoform Selectivity Among Different Types of JAK Inhibitors Evaluated for Rheumatic Diseases Through In Vitro Profiling.
Anniina Virtanen, Maaria Palmroth, Sanna Liukkonen, Antti Kurttila, Teemu Haikarainen

Arthritis Rheumatol· November 2023

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Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening.
Angelika Pölläniemi, Anniina Virtanen, Olli Silvennoinen, Teemu Haikarainen

SLAS Discov· June 2023

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The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.
Juha Saarikettu, Saara Lehmusvaara, Marko Pesu, Ilkka Junttila, Juha Partanen, Teemu Haikarainen

FASEB Bioadv· May 2023

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Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain.
Anniina T Virtanen, Teemu Haikarainen, Parthasarathy Sampathkumar, Maaria Palmroth, Sanna Liukkonen

Pharmaceuticals (Basel)· January 2023

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Aiming for the pocket.
Olli Silvennoinen, Teemu Haikarainen, Anniina Virtanen

Nat Chem Biol· December 2022

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Inhibition of RNA Binding in SND1 Increases the Levels of miR-1-3p and Sensitizes Cancer Cells to Navitoclax.
Saara Lehmusvaara, Teemu Haikarainen, Juha Saarikettu, Guillermo Martinez Nieto, Olli Silvennoinen

Cancers (Basel)· June 2022

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Janus Kinases in Leukemia.
Juuli Raivola, Teemu Haikarainen, Bobin George Abraham, Olli Silvennoinen

Cancers (Basel)· February 2021

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Characterization of JAK1 Pseudokinase Domain in Cytokine Signaling.
Juuli Raivola, Teemu Haikarainen, Olli Silvennoinen

Cancers (Basel)· December 2019

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Small-Molecule Screening Assay for Mono-ADP-Ribosyltransferases.
Teemu Haikarainen, Sudarshan Murthy, Mirko M Maksimainen, Lari Lehtiö

Methods Mol Biol· March 2019

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Selective JAKinibs: Prospects in Inflammatory and Autoimmune Diseases.
Anniina T Virtanen, Teemu Haikarainen, Juuli Raivola, Olli Silvennoinen

BioDrugs· February 2019

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Structural basis for DNA break recognition by ARTD2/PARP2.
Ezeogo Obaji, Teemu Haikarainen, Lari Lehtiö

Nucleic Acids Res· December 2018

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Development of an Inhibitor Screening Assay for Mono-ADP-Ribosyl Hydrolyzing Macrodomains Using AlphaScreen Technology.
Teemu Haikarainen, Mirko M Maksimainen, Ezeogo Obaji, Lari Lehtiö

SLAS Discov· March 2018

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2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Yves Nkizinkiko, Jenny Desantis, Jarkko Koivunen, Teemu Haikarainen, Sudarshan Murthy

Sci Rep· January 2018

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Structural and Biochemical Characterization of Poly-ADP-ribose Polymerase from Trypanosoma brucei.
Teemu Haikarainen, Mariana Schlesinger, Ezeogo Obaji, Silvia H Fernández Villamil, Lari Lehtiö

Sci Rep· June 2017

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Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity.
Amit Nathubhai, Teemu Haikarainen, Jarkko Koivunen, Sudarshan Murthy, Françoise Koumanov

J Med Chem· January 2017

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Characterization of the DNA dependent activation of human ARTD2/PARP2.
Ezeogo Obaji, Teemu Haikarainen, Lari Lehtiö

Sci Rep· October 2016

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Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage.
Harikanth Venkannagari, Patricia Verheugd, Jarkko Koivunen, Teemu Haikarainen, Ezeogo Obaji

Cell Chem Biol· October 2016

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Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases.
Amit Nathubhai, Teemu Haikarainen, Penelope C Hayward, Silvia Muñoz-Descalzo, Andrew S Thompson

Eur J Med Chem· August 2016

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Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.
Teemu Haikarainen, Lari Lehtiö

Sci Rep· April 2016

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Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei.
Mariana Schlesinger, Salomé C Vilchez Larrea, Teemu Haikarainen, Mohit Narwal, Harikanth Venkannagari

Parasit Vectors· March 2016

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