Publications by authors named "Terry Fang"

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Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation.
Magnus Pfaffenbach, Philippe N Bolduc, Zhili Xin, Fang Gao, Ryan Evans, Terry Fang, Rong-Fang Gu

J Med Chem· May 2024

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A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors.
Philippe N Bolduc, Magnus Pfaffenbach, Ryan Evans, Zhili Xin, Kate L Henry, Fang Gao, Terry Fang

ACS Med Chem Lett· May 2024

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The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)--(6-methylpyrazolo[1,5-]pyrimidin-3-yl)imidazo[1,2-]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke.
Ryan Evans, Philippe N Bolduc, Magnus Pfaffenbach, Fang Gao, Tricia May-Dracka, Terry Fang

J Med Chem· March 2024

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Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy.
Barney Viengkhou, Christine Hong, Curt Mazur, Sagar Damle, Nicholas B Gallo, Terry C Fang

J Clin Invest· January 2024

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The impact of rare protein coding genetic variation on adult cognitive function.
Chia-Yen Chen, Ruoyu Tian, Tian Ge, Max Lam, Gabriela Sanchez-Andrade, Terry Fang

Nat Genet· June 2023

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Control of enhancer and promoter activation in the type I interferon response by the histone demethylase Kdm4d/JMJD2d.
Rohit Chandwani, Terry C Fang, Scott Dewell, Alexander Tarakhovsky

Front Immunol· June 2023

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Incidence of Aicardi-Goutières syndrome and -related epilepsy in Denmark.
Rikke S Møller, Liwei Zhao, Jessica R Shoaff, Morten Duno, Brian Nauheimer Andersen, Terry C Fang

Mol Genet Metab Rep· December 2022

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Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation .
J Howard Jones, Zhili Xin, Martin Himmelbauer, Michael Dechantsreiter, Istvan Enyedy, Terry Fang

J Med Chem· October 2021

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Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery.
Mandana Hunter, Krista J Spiller, Myrna A Dominique, Hong Xu, Francis W Hunter, Terry C Fang

Acta Neuropathol Commun· August 2021

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Proteomic Characterization of the Dynamics of Ischemic Stroke in Mice.
Rong-Fang Gu, Terry Fang, Ashley Nelson, Stefka Gyoneva, Benbo Gao

J Proteome Res· July 2021

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A Comparison of Revision Rates and Patient-Reported Outcomes for a 2-Level Posterolateral Fusion Augmented With Single Versus 2-Level Transforaminal Lumbar Interbody Fusion.
I David Kaye, Terry Fang, Scott C Wagner, Joseph S Butler, Arjun Sebastian

Global Spine J· December 2020

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Estimating the relative frequency of leukodystrophies and recommendations for carrier screening in the era of next-generation sequencing.
Johanna L Schmidt, Amy Pizzino, Jessica Nicholl, Allison Foley, Yue Wang, Terry Fang

Am J Med Genet A· August 2020

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MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition.
Xiangdong Lu, Chi-Shuen Chu, Terry Fang, Violeta Rayon-Estrada, Fang Fang

Cell Rep· July 2019

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Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models.
Mona Motwani, Sudesh Pawaria, Jennifer Bernier, Stephanie Moses, Kate Henry, Terry Fang

Proc Natl Acad Sci U S A· April 2019

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Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.
Krista J Spiller, Clark R Restrepo, Tahiyana Khan, Myrna A Dominique, Terry C Fang

Nat Neurosci· March 2018

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PDGF-BB Promotes Type I IFN-Dependent Vascular Alterations and Monocyte Recruitment in a Model of Dermal Fibrosis.
John S Cho, Terry C Fang, Taylor L Reynolds, Daniel J Sofia, Stefan Hamann

PLoS One· August 2017

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Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation.
Marc-Werner Dobenecker, Jong Kyong Kim, Jonas Marcello, Terry C Fang, Rab Prinjha

J Exp Med· March 2015

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Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals.
Will Bailis, Yumi Yashiro-Ohtani, Terry C Fang, Robin D Hatton, Casey T Weaver

Immunity· July 2013

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Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response.
Terry C Fang, Uwe Schaefer, Ingrid Mecklenbrauker, Astrid Stienen, Scott Dewell

J Exp Med· April 2012

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Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.
Yumi Yashiro-Ohtani, Yiping He, Takuya Ohtani, Mary E Jones, Olga Shestova, Terry C Fang

Genes Dev· July 2009

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Notch directly regulates Gata3 expression during T helper 2 cell differentiation.
Terry C Fang, Yumi Yashiro-Ohtani, Cristina Del Bianco, Dawson M Knoblock, Stephen C Blacklow

Immunity· July 2007

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Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation.
Ivan Maillard, Benjamin A Schwarz, Arivazhagan Sambandam, Terry Fang, Olga Shestova

Blood· May 2006

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Notch signaling is an important regulator of type 2 immunity.
Lili Tu, Terry C Fang, David Artis, Olga Shestova, Seth E Pross

J Exp Med· October 2005

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Regulation of lymphoid development, differentiation, and function by the Notch pathway.
Ivan Maillard, Terry Fang, Warren S Pear

Annu Rev Immunol· June 2005

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