Publications by authors named "Theodore Roth"

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Site-specific DNA insertion into the human genome with engineered recombinases.
Alison Fanton, Liam J Bartie, Juliana Q Martins, Vincent Q Tran, Laine Goudy, Theodore L Roth

Nat Biotechnol· November 2025

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Mitochondria redistribution organizes the immunosuppressive tumor ecosystem.
Azusa Terasaki, Alexis T Weiner, Yuhao Tan, Viktoria Szeifert, Keshav Bhatnagar, Theodore Roth

bioRxiv· November 2025

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A unified genetic perturbation language for human cellular programming.
Austin Hartman, Oliver Takacsi-Nagy, Courtney Kernick, Nicole E Theberath, Johnathan Lu, Theodore L Roth

bioRxiv· November 2025

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Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states.
Riley D Z Mullins, Jesse Zaretsky, Emily Stoller, Michael Moore, Oliver Takacsi-Nagy, Theodore L Roth

bioRxiv· October 2025

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Non-viral intron knock-ins for targeted gene integration into human T cells and for T-cell selection.
Theodore L Roth, Johnathan Lu, Alison McClellan, Courtney Kernick, Oliver Takacsi-Nagy

Nat Biomed Eng· August 2025

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Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation.
Quanming Shi, Elana P Simon, Cansu Cimen Bozkus, Anna Kaminska, Leandra Velazquez, Theodore L Roth

Nat Genet· August 2025

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Immune composition of the mononuclear cell fraction of human umbilical cord blood.
Karen Kikuta, Esmond Lee, Talia Menezes, Hannah Fung, Alvaro Amorin, Theodore L Roth

Front Immunol· August 2025

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Latent human herpesvirus 6 is reactivated in CAR T cells.
Caleb A Lareau, Yajie Yin, Katie Maurer, Katalin D Sandor, Bence Daniel, Theodore L Roth

Nature· November 2023

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Modular pooled discovery of synthetic knockin sequences to program durable cell therapies.
Franziska Blaeschke, Yan Yi Chen, Ryan Apathy, Bence Daniel, Andy Y Chen, Theodore L Roth

Cell· September 2023

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High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails.
Brian R Shy, Vivasvan S Vykunta, Alvin Ha, Alexis Talbot, Theodore L Roth

Nat Biotechnol· April 2023

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RASA2 ablation in T cells boosts antigen sensitivity and long-term function.
Julia Carnevale, Eric Shifrut, Nupura Kale, William A Nyberg, Franziska Blaeschke, Theodore L Roth

Nature· September 2022

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A functional map of HIV-host interactions in primary human T cells.
Joseph Hiatt, Judd F Hultquist, Michael J McGregor, Mehdi Bouhaddou, Ryan T Leenay, Theodore L Roth

Nat Commun· April 2022

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Robust T cell activation requires an eIF3-driven burst in T cell receptor translation.
Dasmanthie De Silva, Lucas Ferguson, Grant H Chin, Benjamin E Smith, Ryan A Apathy, Theodore L Roth

Elife· December 2021

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The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28.
Yannick D Muller, Duy P Nguyen, Leonardo M R Ferreira, Patrick Ho, Caroline Raffin, Theodore L Roth

Front Immunol· September 2021

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Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.
Joseph Hiatt, Devin A Cavero, Michael J McGregor, Weihao Zheng, Jonathan M Budzik, Theodore L Roth

Cell Rep· May 2021

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XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment.
Youjin Lee, Derek Bogdanoff, Yutong Wang, George C Hartoularos, Jonathan M Woo, Theodore L Roth

Sci Adv· April 2021

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Epithelial miR-141 regulates IL-13-induced airway mucus production.
Sana Siddiqui, Kristina Johansson, Alex Joo, Luke R Bonser, Kyung Duk Koh, Theodore L Roth

JCI Insight· March 2021

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TCF-1 regulates HIV-specific CD8+ T cell expansion capacity.
Rachel L Rutishauser, Christian Deo T Deguit, Joseph Hiatt, Franziska Blaeschke, Theodore L Roth

JCI Insight· February 2021

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Genetic Disease and Therapy.
Theodore L Roth, Alexander Marson

Annu Rev Pathol· January 2021

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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
David E Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V Rezelj, Svenja Ulferts, Theodore L Roth

Science· December 2020

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Functional CRISPR dissection of gene networks controlling human regulatory T cell identity.
Kathrin Schumann, Siddharth S Raju, Michael Lauber, Saskia Kolb, Eric Shifrut, Theodore L Roth

Nat Immunol· November 2020

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Editing of Endogenous Genes in Cellular Immunotherapies.
Theodore L Roth

Curr Hematol Malig Rep· August 2020

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CRISPR screen in regulatory T cells reveals modulators of Foxp3.
Jessica T Cortez, Elena Montauti, Eric Shifrut, Jovylyn Gatchalian, Yusi Zhang, Theodore L Roth

Nature· June 2020

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A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
David E Gordon, Gwendolyn M Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Theodore L Roth

bioRxiv· March 2020

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