Publications by authors named "Theofilus A Tockary"

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Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity.
Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A Tockary

Mol Ther· May 2024

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Poly(ethylene Glycol) (PEG)-OligoRNA Hybridization to mRNA Enables Fine-Tuned Polyplex PEGylation for Spleen-Targeted mRNA Delivery.
Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A Tockary

Small Sci· April 2024

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Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment.
Theofilus A Tockary, Saed Abbasi, Miki Matsui-Masai, Akimasa Hayashi, Naoto Yoshinaga

Proc Natl Acad Sci U S A· July 2023

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Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer.
Junjie Li, Zhishen Ge, Kazuko Toh, Xueying Liu, Anjaneyulu Dirisala, Theofilus A Tockary

Adv Mater· December 2021

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Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain.
Saed Abbasi, Satoshi Uchida, Kazuko Toh, Theofilus A Tockary, Anjaneyulu Dirisala

J Control Release· April 2021

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Targeting nanoparticles to the brain by exploiting the blood-brain barrier impermeability to selectively label the brain endothelium.
Daniel Gonzalez-Carter, Xueying Liu, Theofilus A Tockary, Anjaneyulu Dirisala, Kazuko Toh

Proc Natl Acad Sci U S A· August 2020

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Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability.
Anjaneyulu Dirisala, Satoshi Uchida, Theofilus A Tockary, Naoto Yoshinaga, Junjie Li

J Drug Target· July 2020

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Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain.
Jinbing Xie, Daniel Gonzalez-Carter, Theofilus A Tockary, Noriko Nakamura, Yonger Xue

ACS Nano· June 2020

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Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines.
Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Shigehito Osawa, Theofilus A Tockary

Sci Adv· June 2020

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Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer.
Theofilus A Tockary, Wanling Foo, Anjaneyulu Dirisala, Qixian Chen, Satoshi Uchida

ACS Nano· November 2019

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Effect of shear stress on structure and function of polyplex micelles from poly(ethylene glycol)-poly(l-lysine) block copolymers as systemic gene delivery carrier.
Kaori M Takeda, Yuichi Yamasaki, Anjaneyulu Dirisala, Sorato Ikeda, Theofilus A Tockary

Biomaterials· May 2017

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Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting.
Qixian Chen, Kensuke Osada, Zhishen Ge, Satoshi Uchida, Theofilus A Tockary

Biomaterials· January 2017

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Poly(ethylene glycol) Crowding as Critical Factor To Determine pDNA Packaging Scheme into Polyplex Micelles for Enhanced Gene Expression.
Kaori M Takeda, Kensuke Osada, Theofilus A Tockary, Anjaneyulu Dirisala, Qixian Chen

Biomacromolecules· January 2017

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Rod-to-Globule Transition of pDNA/PEG-Poly(l-Lysine) Polyplex Micelles Induced by a Collapsed Balance Between DNA Rigidity and PEG Crowdedness.
Theofilus A Tockary, Kensuke Osada, Yusuke Motoda, Shigehiro Hiki, Qixian Chen

Small· March 2016

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Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety.
Satoshi Uchida, Hiroaki Kinoh, Takehiko Ishii, Akitsugu Matsui, Theofilus Agrios Tockary

Biomaterials· March 2016

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Toroidal Packaging of pDNA into Block Ionomer Micelles Exerting Promoted in Vivo Gene Expression.
Yanmin Li, Kensuke Osada, Qixian Chen, Theofilus A Tockary, Anjaneyulu Dirisala

Biomacromolecules· September 2015

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A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle.
Qixian Chen, Kensuke Osada, Matthew Pennisi, Satoshi Uchida, Theofilus A Tockary

Soft Matter· April 2015

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Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors.
Anjaneyulu Dirisala, Kensuke Osada, Qixian Chen, Theofilus A Tockary, Kaori Machitani

Biomaterials· July 2014

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Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors.
Zhishen Ge, Qixian Chen, Kensuke Osada, Xueying Liu, Theofilus A Tockary

Biomaterials· March 2014

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Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.
Qixian Chen, Kensuke Osada, Takehiko Ishii, Makoto Oba, Satoshi Uchida, Theofilus A Tockary

Biomaterials· June 2012

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Enhanced gene expression promoted by the quantized folding of pDNA within polyplex micelles.
Kensuke Osada, Tomonori Shiotani, Theofilus A Tockary, Daigo Kobayashi, Hiroki Oshima

Biomaterials· January 2012

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