Publications by authors named "Therese Ku"

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Targeted inhibition of mu-opioid receptors in neuronal subpopulations by membrane-tethered Naloxo-DART antagonists.
J Sanchez, A Bonifazi, S Groom, M O Sambrook, G A Camacho-Hernandez, E J Kuijer

Cell Chem Biol· December 2025

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Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.
Therese C Ku, Jianjing Cao, Sung Joon Won, Jiqing Guo, Gisela A Camacho-Hernandez, Kuo Hao Lee

ACS Pharmacol Transl Sci· February 2024

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Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.
Amarachi V Okorom, Gisela Andrea Camacho-Hernandez, Kristine Salomon, Kuo Hao Lee, Therese C Ku

J Med Chem· January 2024

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Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach.
Kuo Hao Lee, Andrew D Fant, Jiqing Guo, Andy Guan, Joslyn Jung, Mary Kudaibergenova, Therese Ku

J Chem Inf Model· September 2021

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Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram.
Gisela Andrea Camacho-Hernandez, Andrea Casiraghi, Deborah Rudin, Dino Luethi, Therese C Ku

RSC Med Chem· July 2021

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Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters.
Shreyas Bhat, Daryl A Guthrie, Ameya Kasture, Ali El-Kasaby, Jianjing Cao, Therese Ku

ACS Pharmacol Transl Sci· April 2021

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New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders.
Amy Hauck Newman, Therese Ku, Chloe J Jordan, Alessandro Bonifazi, Zheng-Xiong Xi

Annu Rev Pharmacol Toxicol· January 2021

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Structure-activity relationships for a series of (Bis(4-fluorophenyl)methyl)sulfinylethyl-aminopiperidines and -piperidine amines at the dopamine transporter: Bioisosteric replacement of the piperazine improves metabolic stability.
JoLynn B Giancola, Alessandro Bonifazi, Jianjing Cao, Therese Ku, Alexandra J Haraczy

Eur J Med Chem· December 2020

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Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter.
Daryl A Guthrie, Carmen Klein Herenbrink, Matthew Domenic Lycas, Therese Ku, Alessandro Bonifazi

ACS Chem Neurosci· October 2020

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An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases.
Sophie Vichier-Guerre, Therese C Ku, Sylvie Pochet, Katherine L Seley-Radtke

Chembiochem· May 2020

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Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability.
Rachel D Slack, Therese C Ku, Jianjing Cao, JoLynn B Giancola, Alessandro Bonifazi

J Med Chem· March 2020

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Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1.
Therese Ku, Natalie Lopresti, Matthew Shirley, Mattia Mori, Jan Marchant

Bioorg Med Chem· July 2019

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Thiophene-expanded guanosine analogues of Gemcitabine.
Zhe Chen, Therese C Ku, Katherine L Seley-Radtke

Bioorg Med Chem Lett· October 2015

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Bicyclic and Tricyclic "Expanded" Nucleobase Analogues of Sofosbuvir: New Scaffolds for Hepatitis C Therapies.
Zhe Chen, Dirk Jochmans, Therese Ku, Jan Paeshuyse, Johan Neyts

ACS Infect Dis· August 2015

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Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice.
Megan Podowski, Carla Calvi, Shana Metzger, Kaori Misono, Hataya Poonyagariyagorn, Therese Ku

J Clin Invest· January 2012

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Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride.
Farhat A Khan, Amy J Campbell, Benjamin Hoyt, Christine Herdman, Therese Ku

Life Sci· December 2011

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Critical transition in tissue homeostasis accompanies murine lung senescence.
Carla L Calvi, Megan Podowski, Franco R D'Alessio, Shana L Metzger, Kaori Misono, Therese Ku

PLoS One· November 2011

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Pro-2-PAM therapy for central and peripheral cholinesterases.
James C Demar, Edward D Clarkson, Ruthie H Ratcliffe, Amy J Campbell, Sonia G Thangavelu, Therese C Ku

Chem Biol Interact· September 2010

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