Publications by authors named "Thomas A Edwards"

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Grafted Coiled-Coil Peptides as Multivalent Scaffolds for Protein Recognition.
Amanda M Acevedo-Jake, Bram Mylemans, Danielle F Kay, Peiyu Zhang, Boguslawa Korona, Thomas A Edwards

ACS Chem Biol· June 2025

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Understanding β-strand mediated protein-protein interactions: tuning binding behaviour of intrinsically disordered sequences by backbone modification.
Emma E Cawood, Emily Baker, Thomas A Edwards, Derek N Woolfson, Theodoros K Karamanos

Chem Sci· July 2024

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The cryoEM structure of the Hendra henipavirus nucleoprotein reveals insights into paramyxoviral nucleocapsid architectures.
Tim C Passchier, Joshua B R White, Daniel P Maskell, Matthew J Byrne, Neil A Ranson, Thomas A Edwards

Sci Rep· June 2024

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The Native Orthobunyavirus Ribonucleoprotein Possesses a Helical Architecture.
Francis R Hopkins, Beatriz Álvarez-Rodríguez, George R Heath, Kyriakoulla Panayi, Samantha Hover, Thomas A Edwards

mBio· August 2022

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Understanding p300-transcription factor interactions using sequence variation and hybridization.
Fruzsina Hóbor, Zsófia Hegedüs, Amaurys Avila Ibarra, Vencel L Petrovicz, Gail J Bartlett, Thomas A Edwards

RSC Chem Biol· May 2022

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Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.
Merianne Mohamad, David Nicholson, Chayan Kumar Saha, Vasili Hauryliuk, Thomas A Edwards

Nucleic Acids Res· February 2022

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Towards optimizing peptide-based inhibitors of protein-protein interactions: predictive saturation variation scanning (PreSaVS).
Kristina Hetherington, Som Dutt, Amaurys A Ibarra, Emma E Cawood, Fruzsina Hobor, Thomas A Edwards

RSC Chem Biol· October 2021

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RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site.
Katarzyna Z Haza, Heather L Martin, Ajinkya Rao, Amy L Turner, Sophie E Saunders, Thomas A Edwards

Nat Commun· June 2021

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Development of a multiplex assay for antibody detection in serum against pathogens affecting ruminants.
Alexis C R Hoste, Tamara Ruiz, Paloma Fernández-Pacheco, Miguel Ángel Jiménez-Clavero, Igor Djadjovski, Thomas A Edwards

Transbound Emerg Dis· May 2021

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Query-guided protein-protein interaction inhibitor discovery.
Sergio Celis, Fruzsina Hobor, Thomas James, Gail J Bartlett, Amaurys A Ibarra, Thomas A Edwards

Chem Sci· March 2021

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Selective Affimers Recognise the BCL-2 Family Proteins BCL-x and MCL-1 through Noncanonical Structural Motifs*.
Jennifer A Miles, Fruzsina Hobor, Chi H Trinh, James Taylor, Christian Tiede, Thomas A Edwards

Chembiochem· January 2021

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Identification of β-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation.
Zsófia Hegedüs, Fruzsina Hóbor, Deborah K Shoemark, Sergio Celis, Lu-Yun Lian, Thomas A Edwards

Chem Sci· January 2021

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Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
David Nicholson, Thomas A Edwards, Alex J O'Neill, Neil A Ranson

Structure· October 2020

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A missense variant in specificity protein 6 (SP6) is associated with amelogenesis imperfecta.
Claire E L Smith, Laura L E Whitehouse, James A Poulter, Laura Wilkinson Hewitt, Fatima Nadat, Thomas A Edwards

Hum Mol Genet· June 2020

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Stapled Peptides as HIF-1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency.
Kristina Hetherington, Zsofia Hegedus, Thomas A Edwards, Richard B Sessions, Adam Nelson

Chemistry· June 2020

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Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.
Beatriz Álvarez-Rodríguez, Christian Tiede, Alexis C R Hoste, Rebecca A Surtees, Chi H Trinh, Thomas A Edwards

PLoS Negl Trop Dis· June 2020

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Predicting and Experimentally Validating Hot-Spot Residues at Protein-Protein Interfaces.
Amaurys A Ibarra, Gail J Bartlett, Zsöfia Hegedüs, Som Dutt, Fruzsina Hobor, Thomas A Edwards

ACS Chem Biol· October 2019

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Tula orthohantavirus nucleocapsid protein is cleaved in infected cells and may sequester activated caspase-3 during persistent infection to suppress apoptosis.
Katherine Davies, Babak Afrough, Jamel Mankouri, Roger Hewson, Thomas A Edwards

J Gen Virol· August 2019

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Reply to Rameix-Welti, "No Incongruity in Respiratory Syncytial Virus M2-1 Protein Remaining Bound to Viral mRNAs during Their Entire Life Time".
Thomas A Edwards, John N Barr

mBio· May 2019

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Structure and Function of the Human Respiratory Syncytial Virus M2-1 Protein.
Selvaraj Muniyandi, Georgia Pangratiou, Thomas A Edwards, John N Barr

Subcell Biochem· November 2018

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The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex.
Muniyandi Selvaraj, Kavestri Yegambaram, Eleanor J A A Todd, Charles-Adrien Richard, Rachel L Dods, Thomas A Edwards

mBio· November 2018

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Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening.
Victoria Easton, Martin McPhillie, Isabel Garcia-Dorival, John N Barr, Thomas A Edwards

Antiviral Res· August 2018

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Erratum: Further Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.
George M Burslem, Hannah F Kyle, Adam Nelson, Thomas A Edwards, Andrew J Wilson

Chem Sci· February 2018

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Correction: Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.
George M Burslem, Hannah F Kyle, Adam Nelson, Thomas A Edwards, Andrew J Wilson

Chem Sci· February 2018

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Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
David J Hughes, Christian Tiede, Natalie Penswick, Anna Ah-San Tang, Chi H Trinh, Thomas A Edwards

Sci Signal· November 2017

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