Publications by authors named "Thomas A Hopf"

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Proteome-wide model for human disease genetics.
Rose Orenbuch, Courtney A Shearer, Aaron W Kollasch, Hansen D Spinner, Thomas A Hopf

medRxiv· March 2025

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Deep generative modeling of the human proteome reveals over a hundred novel genes involved in rare genetic disorders.
Rose Orenbuch, Aaron W Kollasch, Hansen D Spinner, Courtney A Shearer, Thomas A Hopf

Res Sq· January 2024

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The EVcouplings Python framework for coevolutionary sequence analysis.
Thomas A Hopf, Anna G Green, Benjamin Schubert, Sophia Mersmann, Charlotta P I Schärfe

Bioinformatics· May 2019

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Evolutionary couplings and sequence variation effect predict protein binding sites.
Maria Schelling, Thomas A Hopf, Burkhard Rost

Proteins· October 2018

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A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.
Eran Kotler, Odem Shani, Guy Goldfeld, Maya Lotan-Pompan, Ohad Tarcic, Thomas A Hopf

Mol Cell· September 2018

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A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.
Eran Kotler, Odem Shani, Guy Goldfeld, Maya Lotan-Pompan, Ohad Tarcic, Thomas A Hopf

Mol Cell· July 2018

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Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis.
Megan Sjodt, Kelly Brock, Genevieve Dobihal, Patricia D A Rohs, Anna G Green, Thomas A Hopf

Nature· April 2018

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Mutation effects predicted from sequence co-variation.
Thomas A Hopf, John B Ingraham, Frank J Poelwijk, Charlotta P I Schärfe, Michael Springer

Nat Biotechnol· February 2017

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Structured States of Disordered Proteins from Genomic Sequences.
Agnes Toth-Petroczy, Perry Palmedo, John Ingraham, Thomas A Hopf, Bonnie Berger

Cell· September 2016

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Protein structure determination by combining sparse NMR data with evolutionary couplings.
Yuefeng Tang, Yuanpeng Janet Huang, Thomas A Hopf, Chris Sander, Debora S Marks

Nat Methods· August 2015

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Amino acid coevolution reveals three-dimensional structure and functional domains of insect odorant receptors.
Thomas A Hopf, Satoshi Morinaga, Sayoko Ihara, Kazushige Touhara, Debora S Marks

Nat Commun· January 2015

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Sequence co-evolution gives 3D contacts and structures of protein complexes.
Thomas A Hopf, Charlotta P I Schärfe, João P G L M Rodrigues, Anna G Green, Oliver Kohlbacher

Elife· September 2014

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FreeContact: fast and free software for protein contact prediction from residue co-evolution.
László Kaján, Thomas A Hopf, Matúš Kalaš, Debora S Marks, Burkhard Rost

BMC Bioinformatics· March 2014

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Homology-based inference sets the bar high for protein function prediction.
Tobias Hamp, Rebecca Kassner, Stefan Seemayer, Esmeralda Vicedo, Christian Schaefer, Thomas A Hopf

BMC Bioinformatics· July 2013

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A large-scale evaluation of computational protein function prediction.
Predrag Radivojac, Wyatt T Clark, Tal Ronnen Oron, Alexandra M Schnoes, Tobias Wittkop, Thomas A Hopf

Nat Methods· March 2013

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Protein structure prediction from sequence variation.
Debora S Marks, Thomas A Hopf, Chris Sander

Nat Biotechnol· November 2012

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Protein 3D structure computed from evolutionary sequence variation.
Debora S Marks, Lucy J Colwell, Robert Sheridan, Thomas A Hopf, Andrea Pagnani

PLoS One· July 2012

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Three-dimensional structures of membrane proteins from genomic sequencing.
Thomas A Hopf, Lucy J Colwell, Robert Sheridan, Burkhard Rost, Chris Sander

Cell· June 2012

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