Publications by authors named "Thomas Caulfield"

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Discovery of an autoinhibited conformation in mesotrypsin reveals a strategy for selective serine protease inhibition.
Matt Coban, Mahesh Gokara, Luis M Forero Vargas, Sarah D Tanzer, Sherry X Zhou, Thomas R Caulfield

Sci Adv· July 2025

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Dynamicasome-a molecular dynamics-guided and AI-driven pathogenicity prediction catalogue for all genetic mutations.
Naeyma N Islam, Mathew A Coban, Jessica M Fuller, Caleb Weber, Rohit Chitale, Thomas R Caulfield

Commun Biol· July 2025

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Conditioned Generative Modeling of Molecular Glues: A Realistic AI Approach for Synthesizable Drug-like Molecules.
Naeyma N Islam, Thomas R Caulfield

Biomolecules· June 2025

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Modeling Lewy body disease with triplication iPSC-derived cortical organoids and identifying therapeutic drugs.
Yunjung Jin, Fuyao Li, Zonghua Li, Tadafumi C Ikezu, Justin O'Leary, Thomas Caulfield

Sci Adv· September 2024

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Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W.
Bernardo A Bustillos, Liam T Cocker, Mathew A Coban, Caleb A Weber, Jenny M Bredenberg, Thomas R Caulfield

Cells· September 2024

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Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research.
Tiffany W Todd, Naeyma N Islam, Casey N Cook, Thomas R Caulfield, Leonard Petrucelli

Neuron· July 2024

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Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases.
Anna Calliari, Lillian M Daughrity, Ellen A Albagli, Paula Castellanos Otero, Mei Yue, Thomas Caulfield

Mol Neurodegener· July 2024

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A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells.
Yasuteru Inoue, Yingxue Ren, Shuwen Zhang, Michael Bamkole, Naeyma N Islam, Thomas R Caulfield

Front Cell Neurosci· July 2024

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The crosstalk between neuropilin-1 and tumor necrosis factor-α in endothelial cells.
Ying Wang, Enfeng Wang, Mohamed Anany, Simone Füllsack, Yu Henry Huo, Thomas Caulfield

Front Cell Dev Biol· June 2024

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Decoding Immuno-Competence: A Novel Analysis of Complete Blood Cell Count Data in COVID-19 Outcomes.
Prakasha Kempaiah, Claudia R Libertin, Rohit A Chitale, Islam Naeyma, Vasili Pleqi, Thomas R Caulfield

Biomedicines· April 2024

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HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases.
Anna Calliari, Lillian M Daughrity, Ellen A Albagli, Paula Castellanos Otero, Mei Yue, Thomas Caulfield

Mol Neurodegener· March 2024

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In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling.
Naeyma N Islam, Caleb A Weber, Matt Coban, Liam T Cocker, Fabienne C Fiesel, Thomas R Caulfield

Biomolecules· March 2024

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Statistical Mechanics Metrics in Pairing and Parsing In Silico and Phenotypic Data of a Novel Genetic NFκB1 (c.T638A) Variant.
Eman N Chaudhri, Jessica M Abbott, Naeyma N Islam, Caleb A Weber, Mathew A Coban, Thomas R Caulfield

Genes (Basel)· September 2023

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Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics.
Yash Gupta, Oleksandr V Savytskyi, Matt Coban, Amoghavarsha Venugopal, Vasili Pleqi, Thomas R Caulfield

Mol Aspects Med· June 2023

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Phenotypic screening models for rapid diagnosis of genetic variants and discovery of personalized therapeutics.
Christopher E Hopkins, Trisha Brock, Thomas R Caulfield, Matthew Bainbridge

Mol Aspects Med· June 2023

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Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.
Fabienne C Fiesel, Dominika Fričová, Caleb S Hayes, Mathew A Coban, Roman Hudec, Thomas R Caulfield

Autophagy· June 2023

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Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase.
Garrett Deletti, Sajan D Green, Caleb Weber, Kristen N Patterson, Swapnil S Joshi, Thomas R Caulfield

Nat Commun· May 2023

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Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure.
Seth Osei Asiedu, Yash Gupta, Vlad Nicolaescu, Haley Gula, Thomas R Caulfield

Int J Mol Sci· April 2023

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Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14.
Hezi Hayun, Matt Coban, Ashok Kumar Bhagat, Eden Ozer, Lital Alfonta, Thomas R Caulfield

Sci Rep· March 2023

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AT-101 Enhances the Antitumor Activity of Lenalidomide in Patients with Multiple Myeloma.
Sikander Ailawadhi, Ricardo D Parrondo, Navnita Dutta, Bing Han, Gina Ciccio, Thomas Caulfield

Cancers (Basel)· January 2023

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Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14.
Hezi Hayun, Matt Coban, Ashok Kumar Bhagat, Eden Ozer, Lital Alfonta, Thomas R Caulfield

Res Sq· January 2023

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Molecular Modeling and Phenotypic Description of a Patient with a Novel Exonic Deletion of with Resultant Morquio Syndrome with Two Successful Pregnancies.
Pavalan Selvam, Angita Jain, Jessica Abbott, Abhimanyu S Ahuja, Anvir Cheema, Thomas Caulfield

Mol Syndromol· July 2022

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Repurposing Lansoprazole and Posaconazole to treat leishmaniasis: Integration of in vitro testing, pharmacological corroboration, and mechanisms of action.
Yash Gupta, Steven Goicoechea, Jesus G Romero, Raman Mathur, Thomas R Caulfield

J Food Drug Anal· March 2022

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-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia.
Chia-Chen Liu, Melissa E Murray, Xia Li, Na Zhao, Na Wang, Thomas Caulfield

Sci Transl Med· September 2021

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Role of PLEXIND1/TGFβ Signaling Axis in Pancreatic Ductal Adenocarcinoma Progression Correlates with the Mutational Status of .
Sneha Vivekanandhan, Vijay S Madamsetty, Ramcharan Singh Angom, Shamit Kumar Dutta, Enfeng Wang, Thomas Caulfield

Cancers (Basel)· August 2021

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