Publications by authors named "Thomas D Y Chung"

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High-throughput screening and characterization of novel inhibitors targeting HIV-1 protease precursor autoprocessing.
Ryan H Jeep, Liangqun Huang, Tram A Ngo, Fu-Yue Zeng, James Boehlke, Thomas D Y Chung

Sci Rep· October 2025

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High-throughput screening of compounds targeting RNA editing in Trypanosoma brucei: Novel molecular scaffolds with broad trypanocidal effects.
Mojtaba Rostamighadi, Arezou Kamelshahroudi, Vaibhav Mehta, Fu-Yue Zeng, Ian Pass, Thomas D Y Chung

Biochem Pharmacol· January 2024

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An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.
Isabell Berneburg, Satyamaheshwar Peddibhotla, Kim C Heimsch, Kristina Haeussler, Patrick Maloney, Thomas D Y Chung

Antimicrob Agents Chemother· April 2022

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Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
Stephanie M Stanford, Michael A Diaz, Robert J Ardecky, Jiwen Zou, Tarmo Roosild, Thomas D Y Chung

J Med Chem· May 2021

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Human Cancers Express TRAILshort, a Dominant Negative TRAIL Splice Variant, Which Impairs Immune Effector Cell Killing of Tumor Cells.
Fatma Aboulnasr, Ashton Krogman, Rondell P Graham, Nathan W Cummins, Anisha Misra, Thomas D Y Chung

Clin Cancer Res· November 2020

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Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.
Anthony B Pinkerton, Satyamaheshwar Peddibhotla, Fusayo Yamamoto, Lauren M Slosky, Yushi Bai, Thomas D Y Chung

J Med Chem· September 2019

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Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.
Yongmei Feng, E Hampton Sessions, Fan Zhang, Fuqiang Ban, Veronica Placencio-Hickok, Thomas D Y Chung

Cancer Lett· May 2019

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Translation to Practice: Accelerating the Cycle of Innovation to Impact.
Jeff R Anderson, Thomas D Y Chung, Leon Clark, Jennifer A Weis, Andrew J Danielsen

Mayo Clin Proc· March 2019

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Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme.
Yi-Jia Li, Li Du, Jianghai Wang, Ramir Vega, Terry D Lee, Thomas D Y Chung

Cell Chem Biol· February 2019

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Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.
Nathan P Coussens, G Sitta Sittampalam, Rajarshi Guha, Kyle Brimacombe, Abigail Grossman, Thomas D Y Chung

Clin Transl Sci· September 2018

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Correction: Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment.
Zilin Nie, Fatma Aboulnasr, Sekar Natesampillai, Stephen P Burke, Ashton Krogman, Thomas D Y Chung

J Immunol· September 2018

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Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment.
Zilin Nie, Fatma Aboulnasr, Sekar Natesampillai, Stephen P Burke, Ashton Krogman, Thomas D Y Chung

J Immunol· February 2018

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TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling.
Tatyana V Masyuk, Anatoliy I Masyuk, Maria Lorenzo Pisarello, Brynn N Howard, Bing Q Huang, Thomas D Y Chung

Hepatology· October 2017

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Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Stephanie M Stanford, Alexander E Aleshin, Vida Zhang, Robert J Ardecky, Michael P Hedrick, Thomas D Y Chung

Nat Chem Biol· June 2017

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Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.
Jing Li, Tanya Yakushi, Francesco Parlati, Andrew L Mackinnon, Christian Perez, Thomas D Y Chung

Nat Chem Biol· May 2017

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ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.
Larry S Barak, Yushi Bai, Sean Peterson, Tama Evron, Nikhil M Urs, Thomas D Y Chung

ACS Chem Biol· July 2016

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New p32/gC1qR Ligands for Targeted Tumor Drug Delivery.
Lauri Paasonen, Shweta Sharma, Gary B Braun, Venkata Ramana Kotamraju, Thomas D Y Chung

Chembiochem· April 2016

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N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore.
Sudeshna Roy, Justina Šileikytė, Benjamin Neuenswander, Michael P Hedrick, Thomas D Y Chung

ChemMedChem· February 2016

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Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore.
Sudeshna Roy, Justina Šileikytė, Marco Schiavone, Benjamin Neuenswander, Francesco Argenton, Thomas D Y Chung

ChemMedChem· October 2015

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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Stuart L Schreiber, Joanne D Kotz, Min Li, Jeffrey Aubé, Christopher P Austin, Thomas D Y Chung, Dong-Hoon Chung

Cell· June 2015

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Design of high-throughput screening assays and identification of a SUMO1-specific small molecule chemotype targeting the SUMO-interacting motif-binding surface.
Aileen Y Alontaga, Yifei Li, Chih-Hong Chen, Chen-Ting Ma, Siobhan Malany, Thomas D Y Chung

ACS Comb Sci· April 2015

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