Publications by authors named "Thomas Emrich"

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Improved targeted delivery of antisense oligonucleotide with an antibody mask.
Hung-En Hsia, Chiara Zanini, Claire Simonneau, Johannes Fraidling, Thomas E Kraft, Thomas Emrich

Nucleic Acids Res· October 2025

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Quantitative polymerase chain reaction in the bioanalytical laboratory and technical and scientific considerations for nonclinical and clinical assay characterization, validation and sample analysis.
Anna Laurén, Manuela Braun, Chiara Cazzin, Kelly Colleti, Chris Cox, Thomas Emrich

Bioanalysis· August 2022

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Comparison of assay formats used for the detection of pre-existing anti-drug antibodies against monoclonal antibodies.
Alexander Pöhler, Thomas Emrich, Gregor Jordan, Martin Schäfer, Kay-Gunnar Stubenrauch

Bioanalysis· July 2022

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Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life.
Algirdas Grevys, Rahel Frick, Simone Mester, Karine Flem-Karlsen, Jeannette Nilsen, Thomas Emrich

iScience· February 2022

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Applying context of use to quantitative polymerase chain reaction method validation and analysis: a recommendation from the European Bioanalysis Forum.
Anna Laurén, Manuela Braun, Paul Byrne, Chiara Cazzin, Kelly Colletti, Thomas Emrich

Bioanalysis· December 2021

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Low immunogenicity of emicizumab in persons with haemophilia A.
Christophe Schmitt, Thomas Emrich, Sammy Chebon, Elena Fernandez, Claire Petry

Haemophilia· November 2021

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Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Antitumor Immunity.
Eva Sum, Moritz Rapp, Philipp Fröbel, Marine Le Clech, Harald Dürr, Thomas Emrich

Clin Cancer Res· July 2021

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Increasing robustness, reliability and storage stability of critical reagents by freeze-drying.
Thomas Emrich, Jan Olaf Stracke, Xiaoying Guo, Kari Damhjell, Joerg Moelleken

Bioanalysis· May 2021

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Heparin chromatography as an predictor for antibody clearance rate through pinocytosis.
Thomas E Kraft, Wolfgang F Richter, Thomas Emrich, Alexander Knaupp, Michaela Schuster

MAbs· January 2021

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Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathology.
Stefan Grathwohl, Emmanuel Quansah, Nazia Maroof, Jennifer A Steiner, Liz Spycher, Thomas Emrich

Free Neuropathol· January 2021

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2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 - Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62).
Steven Piccoli, Devangi Mehta, Alessandra Vitaliti, John Allinson, Shashi Amur, Thomas Emrich

Bioanalysis· December 2019

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Feedback from the European Bioanalysis Forum: focus workshop on current analysis of immunogenicity: best practices and regulatory hurdles.
Joanne Goodman, Simon Cowen, Viswanath Devanarayan, David Egging, Thomas Emrich

Bioanalysis· February 2018

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Comparative assessment of immune complex-mediated hypersensitivity reactions with biotherapeutics in the non-human primate: Critical parameters, safety and lessons for future studies.
Sven Kronenberg, Elisabeth Husar, Christine Schubert, Christian Freichel, Thomas Emrich

Regul Toxicol Pharmacol· August 2017

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A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life.
Pernille Foged Jensen, Angela Schoch, Vincent Larraillet, Maximiliane Hilger, Tilman Schlothauer, Thomas Emrich

Mol Cell Proteomics· March 2017

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Determination of critical quality attributes for monoclonal antibodies using quality by design principles.
Nadja Alt, Taylor Y Zhang, Paul Motchnik, Ron Taticek, Valerie Quarmby, Thomas Emrich

Biologicals· September 2016

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A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies.
Jan Stracke, Thomas Emrich, Petra Rueger, Tilman Schlothauer, Lothar Kling

MAbs· August 2015

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Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics.
Angela Schoch, Hubert Kettenberger, Olaf Mundigl, Gerhard Winter, Julia Engert, Thomas Emrich

Proc Natl Acad Sci U S A· May 2015

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Development of a 4-valent genotyping assay for direct identification of the most frequent Pseudomonas aeruginosa serotypes from respiratory specimens of pneumonia patients.
Holger Koch, Thomas Emrich, Sandra Jampen, Marianne Wyss, Verena Gafner

J Med Microbiol· April 2014

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Comparison of the lateral tail vein and the retro-orbital venous sinus routes of antibody administration in pharmacokinetic studies.
Angela Schoch, Irmgard S Thorey, Julia Engert, Gerhard Winter, Thomas Emrich

Lab Anim (NY)· March 2014

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Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies.
Tilman Schlothauer, Petra Rueger, Jan Olaf Stracke, Hubert Hertenberger, Felix Fingas, Thomas Emrich

MAbs· January 2014

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A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples.
Lutz Eric Lehmann, Klaus-Peter Hunfeld, Thomas Emrich, Gerd Haberhausen, Heimo Wissing

Med Microbiol Immunol· September 2008

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Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies.
Nicasio Mancini, Daniela Clerici, Roberta Diotti, Mario Perotti, Nadia Ghidoli, Thomas Emrich

J Med Microbiol· May 2008

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Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer.
Steffen Weikert, Hans Krause, Ingmar Wolff, Frank Christoph, Mark Schrader, Thomas Emrich

Int J Cancer· November 2005

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Quantitative real-time detection of parvovirus B19 DNA in plasma.
Marco H G M Koppelman, H Theo M Cuypers, Thomas Emrich, Hans L Zaaijer

Transfusion· January 2004

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Quantitative detection of telomerase components by real-time, online RT-PCR analysis with the LightCycler.
Thomas Emrich, Sheng-Yung Chang, Gerlinde Karl, Birgit Panzinger, Chris Santini

Methods Mol Biol· October 2002

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