Publications by authors named "Thomas Faller"

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Rapid Onset and Sustained Efficacy of Onfasprodil (MIJ821), a Novel NR2B Negative Allosteric Modulator, in Patients With Treatment-Resistant Depression: A Phase 2, Randomized, Placebo-Controlled, Proof-of-Concept Study.
Richard C Shelton, Robert E Litman, Howard Hassman, David P Walling, Salvador Ros Montalbán, Thomas Faller

J Clin Psychiatry· August 2025

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MIJ821 (onfasprodil) in healthy volunteers: First-in-human, randomized, placebo-controlled study (single ascending dose and repeated intravenous dose).
Baltazar Gomez-Mancilla, Jeffrey A Levy, Subramanian Ganesan, Thomas Faller, Gil Issachar

Clin Transl Sci· November 2023

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An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion.
Caroline Gubser Keller, Youngah Shin, Alex Mas Monteys, Nicole Renaud, Martin Beibel, Thomas Faller

Nat Commun· March 2022

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Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
Yildiz Yilmaz, Kenichi Umehara, Gareth Williams, Thomas Faller, Hilmar Schiller

Xenobiotica· August 2018

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ADME studies of [5-(3)H]-2'-O-methyluridine nucleoside in mice: a building block in siRNA therapeutics.
Frederic Lozac'h, Jesper Christensen, Thomas Faller, Esther van de Kerkhof, Joel Krauser

Pharmacol Res Perspect· February 2016

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Biodistribution and metabolism studies of lipid nanoparticle-formulated internally [3H]-labeled siRNA in mice.
Jesper Christensen, Karine Litherland, Thomas Faller, Esther van de Kerkhof, François Natt

Drug Metab Dispos· March 2014

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Ethylene oxide in blood of ethylene-exposed B6C3F1 mice, Fischer 344 rats, and humans.
Johannes Georg Filser, Winfried Kessler, Anna Artati, Eva Erbach, Thomas Faller

Toxicol Sci· December 2013

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Whole-body scanning PCR; a highly sensitive method to study the biodistribution of mRNAs, noncoding RNAs and therapeutic oligonucleotides.
Julien A Boos, David W Kirk, Mari-Luz Piccolotto, Werner Zuercher, Sandro Gfeller, Thomas Faller

Nucleic Acids Res· August 2013

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Metabolism studies of unformulated internally [3H]-labeled short interfering RNAs in mice.
Jesper Christensen, Karine Litherland, Thomas Faller, Esther van de Kerkhof, François Natt

Drug Metab Dispos· June 2013

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Quantitative investigation on the metabolism of 1,3-butadiene and of its oxidized metabolites in once-through perfused livers of mice and rats.
Johannes G Filser, Swati Bhowmik, Thomas H Faller, Christoph Hutzler, Winfried Kessler

Toxicol Sci· March 2010

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Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats.
Gerard J M Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick

Drug Metab Dispos· December 2008

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Inhalation and epidermal exposure of volunteers to ethylene glycol: kinetics of absorption, urinary excretion, and metabolism to glycolate and oxalate.
Swapna Upadhyay, Joern Carstens, Dominik Klein, Thomas H Faller, Stephan Halbach

Toxicol Lett· May 2008

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Concentrations of the propylene metabolite propylene oxide in blood of propylene-exposed rats and humans--a basis for risk assessment.
Johannes G Filser, Christoph Hutzler, Florian Rampf, Winfried Kessler, Thomas H Faller

Toxicol Sci· April 2008

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Styrene-7,8-oxide burden in ventilated, perfused lungs of mice and rats exposed to vaporous styrene.
Christiana Hofmann, Christian Pütz, Brigitte Semder, Thomas H Faller, György A Csanády

Toxicol Sci· March 2006

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Propylene oxide in blood and soluble nonprotein thiols in nasal mucosa and other tissues of male Fischer 344/N rats exposed to propylene oxide vapors--relevance of glutathione depletion for propylene oxide-induced rat nasal tumors.
Moung S Lee, Thomas H Faller, Paul E Kreuzer, Winfried Kessler, György A Csanády

Toxicol Sci· January 2005

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Dosimetry by means of DNA and hemoglobin adducts in propylene oxide-exposed rats.
Siv Osterman-Golkar, Kamila Czene, Moung Sook Lee, Thomas H Faller, György A Csanády

Toxicol Appl Pharmacol· September 2003

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Human inhalation exposure to ethylene glycol.
Jörn Carstens, György A Csanády, Thomas H Faller, Johannes G Filser

Arch Toxicol· August 2003

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Molecular dosimetry of N7-(2-hydroxypropyl)guanine in tissues of F344 rats after inhalation exposure to propylene oxide.
Melva N Ríos-Blanco, Asoka Ranasinghe, Moung S Lee, Thomas Faller, Johannes G Filser

Carcinogenesis· July 2003

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