Publications by authors named "Thomas Hehlgans"

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DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts.
Niklas Beumer, Charles D Imbusch, Tamara Kaufmann, Lisa Schmidleithner, Kathrin Gütter, Thomas Hehlgans

Nat Immunol· August 2025

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Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells.
Malte Simon, Philipp Stüve, Lisa Schmidleithner, Sebastian Bittner, Niklas Beumer, Thomas Hehlgans

Immunity· August 2024

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The effector program of human CD8 T cells supports tissue remodeling.
Michael Delacher, Lisa Schmidleithner, Malte Simon, Philipp Stüve, Lieke Sanderink, Thomas Hehlgans

J Exp Med· February 2024

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Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond.
Sebastian Bittner, Thomas Hehlgans, Markus Feuerer

Trends Immunol· June 2023

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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1 T lymphocyte niches through a feed-forward loop.
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Thomas Hehlgans

Cancer Cell· January 2023

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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1 T lymphocyte niches through a feed-forward loop.
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Thomas Hehlgans

Cancer Cell· December 2022

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Biosensors for inflammation as a strategy to engineer regulatory T cells for cell therapy.
Sebastian Bittner, Brigitte Ruhland, Veronika Hofmann, Lisa Schmidleithner, Kathrin Schambeck, Thomas Hehlgans

Proc Natl Acad Sci U S A· October 2022

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Alloreactive Tissue-resident Memory T Cells in Solid Organ Transplantation: Do They Light the Fire?
Philipp Stüve, Thomas Hehlgans, Markus Feuerer

Transplantation· October 2022

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Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors.
Elisa Lenti, Luca Genovese, Silvia Bianchessi, Aurora Maurizio, Simona Baghai Sain, Thomas Hehlgans

Immunity· April 2022

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Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function.
Hung-Wei Cheng, Urs Mörbe, Mechthild Lütge, Céline Engetschwiler, Lucas Onder, Thomas Hehlgans

Nat Commun· April 2022

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Propionate induces cross-tolerance to TLR1/2 and TLR4 agonists in an IFIT-dependent manner.
Christina Fischer, Dorothea Weber-Steffens, Marina Kreutz, Thomas Hehlgans

Immunobiology· March 2022

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CD169 macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling.
Abdouramane Camara, Alice C Lavanant, Jun Abe, Henri Lee Desforges, Yannick O Alexandre, Thomas Hehlgans

Proc Natl Acad Sci U S A· January 2022

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Lymphotoxin-β-receptor (LTβR) signaling on hepatocytes is required for liver regeneration after partial hepatectomy.
Ursula R Sorg, Nicole Küpper, Julia Mock, Anne Tersteegen, Patrick Petzsch, Thomas Hehlgans

Biol Chem· August 2021

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Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells.
Michael Delacher, Malte Simon, Lieke Sanderink, Agnes Hotz-Wagenblatt, Marina Wuttke, Thomas Hehlgans

Immunity· April 2021

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Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.
Fabian Guendel, Michael Kofoed-Branzk, Konrad Gronke, Caroline Tizian, Mario Witkowski, Thomas Hehlgans

Immunity· November 2020

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Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways.
Marleen Gloger, Lutz Menzel, Michael Grau, Anne-Clemence Vion, Ioannis Anagnostopoulos, Thomas Hehlgans

Cancer Res· March 2020

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Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.
Hung-Wei Cheng, Lucas Onder, Mario Novkovic, Charlotte Soneson, Mechthild Lütge, Thomas Hehlgans

Nat Commun· April 2019

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Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation.
Tobias Schmid, Lena Falter, Sabine Weber, Nils Müller, Konstantin Molitor, Thomas Hehlgans

Front Immunol· November 2017

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The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation.
Daniela Weber, Katrin Frauenschläger, Sakhila Ghimire, Katrin Peter, Isabella Panzer, Thomas Hehlgans

PLoS One· October 2017

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Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis.
Lucas Onder, Urs Mörbe, Natalia Pikor, Mario Novkovic, Hung-Wei Cheng, Thomas Hehlgans

Immunity· July 2017

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Human beta-defensin-2 and -3 enhance pro-inflammatory cytokine expression induced by TLR ligands via ATP-release in a P2X7R dependent manner.
Daniela Wanke, Katrin Mauch-Mücke, Ernst Holler, Thomas Hehlgans

Immunobiology· November 2016

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IL-10 from marginal zone precursor B cells controls the differentiation of Th17, Tfh and Tfr cells in transplantation tolerance.
Girdhari Lal, Neeraja Kulkarni, Yumi Nakayama, Amit K Singh, Apoorva Sethi, Thomas Hehlgans

Immunol Lett· February 2016

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Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation.
Kristina Heinig, Marcel Gätjen, Michael Grau, Vanessa Stache, Ioannis Anagnostopoulos, Thomas Hehlgans

Cancer Discov· December 2014

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LTβR expression on hematopoietic cells regulates acute inflammation and influences maturation of myeloid subpopulations.
Anja K Wege, Barbara Huber, Nadin Wimmer, Daniela N Männel, Thomas Hehlgans

Innate Immun· July 2014

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Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease.
Ernst Holler, Peter Butzhammer, Karin Schmid, Christian Hundsrucker, Josef Koestler, Thomas Hehlgans

Biol Blood Marrow Transplant· May 2014

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