Publications by authors named "Thomas Hesterkamp"

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Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections.
Aditya Shekhar, Raffaella Di Lucrezia, Karoline Jerye, Vadim S Korotkov, Kirsten Harmrolfs, Thomas Hesterkamp

Cell Host Microbe· April 2025

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Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters.
Katharina Rox, Annett Kühne, Jennifer Herrmann, Rolf Jansen, Stephan Hüttel, Thomas Hesterkamp

ACS Pharmacol Transl Sci· July 2024

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Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models.
Katharina Rox, Rolf Jansen, Tadeja Lukežič, Marina Greweling-Pils, Jennifer Herrmann, Thomas Hesterkamp

Microbiol Spectr· January 2024

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MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humans.
Leonie Mayer, Leonie M Weskamm, Anahita Fathi, Maya Kono, Jasmin Heidepriem, Thomas Hesterkamp

NPJ Vaccines· January 2024

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Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials.
Sebastian Walesch, Joy Birkelbach, Gwenaëlle Jézéquel, F P Jake Haeckl, Julian D Hegemann, Thomas Hesterkamp

EMBO Rep· January 2023

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Potent and Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A.
Jennifer L Edwards, Jacqueline T Balthazar, Danillo L A Esposito, Julio C Ayala, Andrea Schiefer, Thomas Hesterkamp

mSphere· October 2022

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Corallopyronin A: antimicrobial discovery to preclinical development.
Anna K Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Michael Gütschow, Thomas Hesterkamp

Nat Prod Rep· September 2022

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In Vitro-In Vivo Relationship in Mini-Scale-Enabling Formulations of Corallopyronin A.
Tim Becker, Anna K Krome, Sahel Vahdati, Andrea Schiefer, Kenneth Pfarr, Thomas Hesterkamp

Pharmaceutics· August 2022

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Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome.
Anahita Fathi, Christine Dahlke, Verena Krähling, Alexandra Kupke, Nisreen M A Okba, Thomas Hesterkamp

Nat Commun· July 2022

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The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in .
Jan Balansky, Kenneth Pfarr, Christiane Szekat, Stefan Kehraus, Tilman Aden, Thomas Hesterkamp

Antibiotics (Basel)· July 2022

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Towards the sustainable discovery and development of new antibiotics.
Marcus Miethke, Marco Pieroni, Tilmann Weber, Mark Brönstrup, Peter Hammann, Thomas Hesterkamp

Nat Rev Chem· October 2021

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Towards the sustainable discovery and development of new antibiotics.
Marcus Miethke, Marco Pieroni, Tilmann Weber, Mark Brönstrup, Peter Hammann, Thomas Hesterkamp

Nat Rev Chem· August 2021

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Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections.
Andrea Schiefer, Marc P Hübner, Anna Krome, Christine Lämmer, Alexandra Ehrens, Thomas Hesterkamp

PLoS Negl Trop Dis· December 2020

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Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A.
Anna K Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Christian Steinebach, Thomas Hesterkamp

Pharmaceutics· November 2020

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Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin.
Fabienne Hennessen, Marcus Miethke, Nestor Zaburannyi, Maria Loose, Tadeja Lukežič, Thomas Hesterkamp

Antibiotics (Basel)· September 2020

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Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome: an open-label, phase 1 trial.
Till Koch, Christine Dahlke, Anahita Fathi, Alexandra Kupke, Verena Krähling, Thomas Hesterkamp

Lancet Infect Dis· July 2020

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Antibiotics Clinical Development and Pipeline.
Thomas Hesterkamp

Curr Top Microbiol Immunol· June 2017

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On the prediction of statistical parameters in high-throughput screening using resampling techniques.
Pierre E Ilouga, Thomas Hesterkamp

J Biomol Screen· July 2012

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Discovery of a novel Hsp90 inhibitor by fragment linking.
John J Barker, Oliver Barker, Stephen M Courtney, Mihaly Gardiner, Thomas Hesterkamp

ChemMedChem· October 2010

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Fragment-based discovery and optimization of BACE1 inhibitors.
James Madden, Jenny R Dod, Robert Godemann, Joachim Kraemer, Myron Smith, Thomas Hesterkamp

Bioorg Med Chem Lett· September 2010

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High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand.
Robert Cheng, Brunella Felicetti, Shilpa Palan, Ian Toogood-Johnson, Christoph Scheich, Thomas Hesterkamp

Protein Sci· January 2010

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Fragment-based discovery of BACE1 inhibitors using functional assays.
Robert Godemann, James Madden, Joachim Krämer, Myron Smith, Ulrike Fritz, Thomas Hesterkamp

Biochemistry· November 2009

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Novel MK2 inhibitors by fragment screening.
Oliver Keminer, Joachim Kraemer, Jan Kahmann, Ina Sternberger, Christoph Scheich, Thomas Hesterkamp

Comb Chem High Throughput Screen· August 2009

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The multiple roles of computational chemistry in fragment-based drug design.
Richard Law, Oliver Barker, John J Barker, Thomas Hesterkamp, Robert Godemann

J Comput Aided Mol Des· August 2009

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A multiplexed approach to hit finding.
Mark Slack, Dirk Winkler, Joachim Krämer, Thomas Hesterkamp

Curr Opin Drug Discov Devel· May 2009

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