Publications by authors named "Thomas Irving"

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MuscleX-DI: an integrated data analysis package for X-ray scanning diffraction imaging experiments.
Rama S Madhurapantula, Jiranun Jiratrakanvong, Grant Nikseresht, Nikhil Miskin, Ran Huo, Thomas C Irving

J Synchrotron Radiat· January 2026

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Myosin Modulator Aficamten Inhibits Force by Altering Myosin's Biochemical Activity Without Changing Thick Filament Structure.
Saffie Mohran, Kristina B Kooiker, Ateeqa Naim, Matvey Pilagov, Anthony Asencio, Thomas C Irving

JACC Basic Transl Sci· December 2025

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Annotating the x-ray diffraction pattern of vertebrate striated muscle.
Natalia A Koubassova, Debabrata Dutta, Weikang Ma, Andrey K Tsaturyan, Thomas Irving

Biophys J· November 2025

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Mavacamten facilitates myosin head ON-to-OFF transitions and shortens thin filament length in relaxed mouse skeletal muscle.
Michel N Kuehn, Nichlas M Engels, Devin L Nissen, Johanna K Freundt, Weikang Ma, Thomas C Irving

Physiol Rep· October 2025

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From glomalin to glomalose: unraveling the molecular identity of the MAb32B11 antigen.
Burcu Alptekin, Hayley Hirsch, Bailey Kleven, Lauren King, Caitlin McLimans, Thomas Irving

New Phytol· September 2025

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Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy.
Giulia Arecchi, Marica Dente, Weikang Ma, Beatrice Scellini, Nicoletta Piroddi, Thomas C Irving

bioRxiv· May 2025

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Myosin modulator Aficamten inhibits force in cardiac muscle by altering myosin's biochemical activity without changing thick filament structure.
Saffie Mohran, Kristina B Kooiker, Ateeqa Naim, Matvey Pilagov, Anthony Asencio, Thomas C Irving

bioRxiv· May 2025

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Load-dependence of the activation of myosin filaments in heart muscle.
Yanhong Wang, Luca Fusi, Jesus G Ovejero, Cameron Hill, Samina Juma, Thomas Irving, Malcolm Irving

J Physiol· December 2024

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Mavacamten facilitates myosin head ON-to-OFF transitions and shortens thin filament length in relaxed skeletal muscle.
Michel N Kuehn, Nichlas M Engels, Devin L Nissen, Johanna K Freundt, Weikang Ma, Thomas C Irving

bioRxiv· December 2024

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The distinctive mechanical and structural signatures of residual force enhancement in myofibers.
Anthony L Hessel, Michel N Kuehn, Bradley M Palmer, Devin Nissen, Dhruv Mishra, Thomas C Irving

Proc Natl Acad Sci U S A· December 2024

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Calcium has a direct effect on thick filament activation in porcine myocardium.
Saffie Mohran, Timothy S McMillen, Christian Mandrycky, An-Yue Tu, Kristina B Kooiker, Thomas C Irving

J Gen Physiol· November 2024

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Seeing hormones in action: High-resolution gibberellin dynamics in nodules.
Min-Yao Jhu, Thomas B Irving

Plant Cell· October 2024

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Mechanisms of a novel regulatory light chain-dependent cardiac myosin inhibitor.
Kristina Kooiker, Qing-Fen Gan, Ming Yu, Na Sa, Saffie Mohran, Thomas C Irving

J Gen Physiol· October 2024

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The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca].
Kyrah L Turner, Blake J Vander Top, Kristina B Kooiker, Saffie Mohran, Christian Mandrycky, Thomas C Irving

J Physiol· October 2024

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MuscleX: data analysis software for fiber diffraction patterns from muscle.
Jiranun Jiratrakanvong, Jinjian Shao, Jiaqi Li, Miguel Menendez Alvarez, Xintian Li, Thomas C Irving

J Synchrotron Radiat· September 2024

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Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients.
Marloes van den Berg, Zhonghua Shi, Wout J Claassen, Pleuni Hooijman, Christopher T A Lewis, Thomas Irving

Sci Transl Med· July 2024

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Differences in thick filament activation in fast rodent skeletal muscle and slow porcine cardiac muscle.
Jing Zhao, Lin Qi, Shengyao Yuan, Thomas C Irving, Weikang Ma

J Physiol· June 2024

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Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.
Anthony L Hessel, Michel N Kuehn, Seong-Won Han, Weikang Ma, Thomas C Irving

Commun Biol· May 2024

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Titin-Based Force Modulates Cardiac Thick and Thin Filaments.
Anthony L Hessel, Michel N Kuehn, Nichlas M Engels, Devin L Nissen, Johanna K Freundt, Thomas C Irving

Circ Res· April 2024

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Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads.
Anthony L Hessel, Nichlas M Engels, Michel N Kuehn, Devin Nissen, Rachel L Sadler, Thomas C Irving

Nat Commun· March 2024

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KBTBD13 is an actin-binding protein that modulates muscle kinetics.
Josine M de Winter, Joery P Molenaar, Michaela Yuen, Robbert van der Pijl, Shengyi Shen, Thomas Irving

J Clin Invest· February 2024

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The structural OFF and ON states of myosin can be decoupled from the biochemical super- and disordered-relaxed states.
Vivek P Jani, Taejeong Song, Chengqian Gao, Henry Gong, Sakthivel Sadayappan, Thomas C Irving

PNAS Nexus· February 2024

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Myosin in autoinhibited state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions.
Weikang Ma, Carlos L Del Rio, Lin Qi, Momcilo Prodanovic, Srboljub Mijailovich, Thomas C Irving

Proc Natl Acad Sci U S A· February 2024

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Titin-based force regulates cardiac myofilament structures mediating length-dependent activation.
Anthony L Hessel, Michel N Kuehn, Nichlas M Engels, Devin L Nissen, Johanna K Freundt, Thomas C Irving

bioRxiv· November 2023

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Unlocking the Role of sMyBP-C: A Key Player in Skeletal Muscle Development and Growth.
Taejeong Song, James W McNamara, Akhil Baby, Weikang Ma, Maicon Landim-Vieira, Thomas C Irving

bioRxiv· November 2023

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