Publications by authors named "Malcolm Irving"

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Calcium binding to troponin C is required for activation of the myosin-containing thick filaments in rat cardiac trabeculae.
Michaeljohn Kalakoutis, Yanhong Wang, Emma Smith, Alice Arcidiacono, Cameron Hill, Malcolm Irving

J Mol Cell Cardiol· August 2025

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Dual-filament regulation of relaxation in mammalian fast skeletal muscle.
Cameron Hill, Michaeljohn Kalakoutis, Alice Arcidiacono, Flair Paradine Cullup, Yanhong Wang, Malcolm Irving

Proc Natl Acad Sci U S A· March 2025

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Functional control of myosin motors in the cardiac cycle.
Malcolm Irving

Nat Rev Cardiol· January 2025

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Load-dependence of the activation of myosin filaments in heart muscle.
Yanhong Wang, Luca Fusi, Jesus G Ovejero, Cameron Hill, Samina Juma, Thomas Irving, Malcolm Irving

J Physiol· December 2024

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Structural changes in troponin during activation of skeletal and heart muscle determined in situ by polarised fluorescence.
Ivanka R Sevrieva, Thomas Kampourakis, Malcolm Irving

Biophys Rev· December 2024

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Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle.
Marco Caremani, Luca Fusi, Massimo Reconditi, Gabriella Piazzesi, Theyencheri Narayanan, Malcolm Irving

J Gen Physiol· December 2023

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Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism.
Elisabetta Brunello, Lorenzo Marcucci, Malcolm Irving, Luca Fusi

Proc Natl Acad Sci U S A· May 2023

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In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells.
Jessica Chandler, Conor Treacy, Simon Ameer-Beg, Elisabeth Ehler, Malcolm Irving

Proc Natl Acad Sci U S A· March 2023

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Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A.
Ivanka R Sevrieva, Saraswathi Ponnam, Ziqian Yan, Malcolm Irving, Thomas Kampourakis

J Biol Chem· January 2023

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Activation of the myosin motors in fast-twitch muscle of the mouse is controlled by mechano-sensing in the myosin filaments.
Cameron Hill, Elisabetta Brunello, Luca Fusi, Jesús Garcia Ovejero, Malcolm Irving

J Physiol· September 2022

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Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation.
Jesus G Ovejero, Luca Fusi, So-Jin Park-Holohan, Andrea Ghisleni, Theyencheri Narayanan, Malcolm Irving

J Gen Physiol· March 2022

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Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle.
Massimo Reconditi, Elisabetta Brunello, Luca Fusi, Marco Linari, Vincenzo Lombardi, Malcolm Irving

J Gen Physiol· November 2021

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The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle.
Thomas Kampourakis, Malcolm Irving

Nat Commun· September 2021

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Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle.
Cameron Hill, Elisabetta Brunello, Luca Fusi, Jesús G Ovejero, Malcolm Irving

Elife· June 2021

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Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing.
So-Jin Park-Holohan, Elisabetta Brunello, Thomas Kampourakis, Martin Rees, Malcolm Irving

Proc Natl Acad Sci U S A· April 2021

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Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing.
Marco Caremani, Luca Fusi, Marco Linari, Massimo Reconditi, Gabriella Piazzesi, Thomas C Irving, Malcolm Irving

J Gen Physiol· March 2021

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Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I.
Ivanka R Sevrieva, Birgit Brandmeier, Saraswathi Ponnam, Mathias Gautel, Malcolm Irving

J Biol Chem· April 2020

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Myosin filament-based regulation of the dynamics of contraction in heart muscle.
Elisabetta Brunello, Luca Fusi, Andrea Ghisleni, So-Jin Park-Holohan, Jesus G Ovejero, Malcolm Irving

Proc Natl Acad Sci U S A· April 2020

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Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation.
Marco Caremani, Elisabetta Brunello, Marco Linari, Luca Fusi, Thomas C Irving, Malcolm Irving

J Gen Physiol· November 2019

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Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle.
Saraswathi Ponnam, Ivanka Sevrieva, Yin-Biao Sun, Malcolm Irving, Thomas Kampourakis

Proc Natl Acad Sci U S A· July 2019

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Thick Filament Length Changes in Muscle Have Both Elastic and Structural Components.
Massimo Reconditi, Luca Fusi, Marco Caremani, Elisabetta Brunello, Marco Linari, Malcolm Irving

Biophys J· March 2019

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Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions.
Thomas Kampourakis, Saraswathi Ponnam, Yin-Biao Sun, Ivanka Sevrieva, Malcolm Irving

J Biol Chem· September 2018

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Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle.
Thomas Kampourakis, Saraswathi Ponnam, Malcolm Irving

J Mol Cell Cardiol· April 2018

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Reversible Covalent Reaction of Levosimendan with Cardiac Troponin C in Vitro and in Situ.
Brittney A Klein, Béla Reiz, Ian M Robertson, Malcolm Irving, Liang Li

Biochemistry· April 2018

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Regulation of Contraction by the Thick Filaments in Skeletal Muscle.
Malcolm Irving

Biophys J· December 2017

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