Publications by authors named "Thomas Keck"

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Asymmetric Dynamics Between the Protomers of the σ2 Receptor Homodimer.
Manming Xu, Saleh Alyemni, Veniamin A Borin, Ranabir Majumder, Nathaniel V Nucci, Thomas Keck

J Chem Inf Model· November 2025

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Novel Dopamine 4 Receptor Ligands Differentially Ameliorate ADHD-like Behaviors in Spontaneously Hypertensive Rats.
Ike C de la Peña, Samantha Andino, Ashley Amis, Mohammad A Alkhatib, Tian Li, Thomas M Keck

bioRxiv· November 2025

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The CB1 negative allosteric modulator PSNCBAM-1 reduces ethanol self-administration via a nonspecific hypophagic effect.
Harley M Buechler, Mousumi Sumi, Indu Mithra Madhuranthakam, Christa Donegan, Frank DiGiorgio, Thomas M Keck

Pharmacol Biochem Behav· July 2024

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Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder.
Comfort A Boateng, Ashley N Nilson, Rebekah Placide, Mimi L Pham, Franziska M Jakobs, Thomas M Keck

J Med Chem· September 2023

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Decoding brain memory formation by single-cell RNA sequencing.
Atlas M Sardoo, Shaoqiang Zhang, Thomas N Ferraro, Thomas M Keck, Yong Chen

Brief Bioinform· November 2022

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Functional and pharmacological role of the dopamine D receptor and its polymorphic variants.
Sergi Ferré, Annabelle M Belcher, Jordi Bonaventura, César Quiroz, Marta Sánchez-Soto, Thomas M Keck

Front Endocrinol (Lausanne)· October 2022

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Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders.
Alessandro Bonifazi, Amy H Newman, Thomas M Keck, Silvia Gervasoni, Giulio Vistoli

ACS Chem Neurosci· October 2021

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Synergistic antihyperalgesic and antinociceptive effects of morphine and methyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (MP-III-024): a positive allosteric modulator at α2GABA and α3GABA receptors.
Mohammad A Rahman, Thomas M Keck, Michael M Poe, Dishary Sharmin, James M Cook

Psychopharmacology (Berl)· June 2021

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Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA.
Ariful Islam, Mohammad Atiqur Rahman, Megan B Brenner, Allamar Moore, Alyssa Kellmyer, Thomas M Keck

ACS Pharmacol Transl Sci· October 2020

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Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms.
Catherine A Schweppe, Caitlin Burzynski, Subramaniam Jayanthi, Bruce Ladenheim, Jean Lud Cadet, Thomas M Keck

Psychopharmacology (Berl)· July 2020

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Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D Dopamine Receptor Agonist.
Amy E Moritz, R Benjamin Free, Warren S Weiner, Emmanuel O Akano, Disha Gandhi, Thomas M Keck

J Med Chem· May 2020

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Cognitive and behavioral effects of brief seizures in mice.
Alexander I Batterman, James DeChiara, Ariful Islam, Megan B Brenner, Bradford D Fischer, Thomas M Keck

Epilepsy Behav· September 2019

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Multitarget 1,4-Dioxane Compounds Combining Favorable D-like and 5-HT Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia.
Fabio Del Bello, Dario Ambrosini, Alessandro Bonifazi, Amy H Newman, Thomas M Keck

ACS Chem Neurosci· May 2019

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Dopamine D Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy.
Thomas M Keck, R Benjamin Free, Marilyn M Day, Sonvia L Brown, Michele S Maddaluna

J Med Chem· April 2019

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Wrist Kinematics and Kinetics during Wheelchair Propulsion with a Novel Handle-based Propulsion Mechanism.
Nithin Babu Rajendra Kurup, Markus Puchinger, Thomas Keck, Margit Gfoehler

Annu Int Conf IEEE Eng Med Biol Soc· July 2018

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Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D Receptor (DR).
Vivek Kumar, Amy E Moritz, Thomas M Keck, Alessandro Bonifazi, Michael P Ellenberger

J Med Chem· February 2017

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The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT receptor over α-adrenoceptor and D-like receptor subtypes.
Fabio Del Bello, Alessandro Bonifazi, Mario Giannella, Gianfabio Giorgioni, Alessandro Piergentili, Thomas M Keck

Eur J Med Chem· January 2017

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Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D Receptor.
Mayako Michino, Comfort A Boateng, Prashant Donthamsetti, Hideaki Yano, Oluyomi M Bakare, Thomas M Keck

J Med Chem· January 2017

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A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus.
Valerio Mammoli, Alessandro Bonifazi, Diego Dal Ben, Mario Giannella, Gianfabio Giorgioni, Thomas M Keck

ChemMedChem· August 2016

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Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.
Vivek Kumar, Alessandro Bonifazi, Michael P Ellenberger, Thomas M Keck, Elie Pommier

J Med Chem· August 2016

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Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity.
Mu-Fa Zou, Thomas M Keck, Vivek Kumar, Prashant Donthamsetti, Mayako Michino

J Med Chem· April 2016

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High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.
Comfort A Boateng, Oluyomi M Bakare, Jia Zhan, Ashwini K Banala, Caitlin Burzynski, Thomas M Keck

J Med Chem· August 2015

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Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.
Thomas M Keck, Ashwini K Banala, Rachel D Slack, Caitlin Burzynski, Alessandro Bonifazi

Bioorg Med Chem· July 2015

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Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.
Thomas M Keck, William S John, Paul W Czoty, Michael A Nader, Amy Hauck Newman

J Med Chem· July 2015

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Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.
Vivek Kumar, Ashwini K Banala, Erick G Garcia, Jianjing Cao, Thomas M Keck

ACS Med Chem Lett· June 2014

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