Publications by authors named "Thomas Lemcke"

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Regulation of dual leucine zipper kinase activity through its interaction with calcineurin.
J Duque Escobar, Anna Kutschenko, Sabine Schröder, Roland Blume, Kyra-Alexandra Köster, Thomas Lemcke

Cell Signal· June 2021

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Dual leucine zipper kinase (MAP3K12) modulators: a patent review (2010-2015).
Elke Oetjen, Thomas Lemcke

Expert Opin Ther Pat· May 2016

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3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3.
Wiebke Fugel, Anselm Erich Oberholzer, Bernhard Gschloessl, Ron Dzikowski, Narkiss Pressburger, Thomas Lemcke

J Med Chem· January 2013

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Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure.
Stefanie Schmidt, Lutz Preu, Thomas Lemcke, Frank Totzke, Christoph Schächtele

Eur J Med Chem· July 2011

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Identification of Inhibitors of the Tyrosine Kinase c-Met by Structure-Based Virtual Screening.
Thomas Lemcke, Jan Dreher, Matthias Rarey, Frank Totzke, Christoph Schächtele

Mol Inform· March 2011

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Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl)nicotinonitrile scaffold.
Wiebke Brandt, Luca Mologni, Lutz Preu, Thomas Lemcke, Carlo Gambacorti-Passerini

Eur J Med Chem· July 2010

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Generation and evaluation of a homology model of PfGSK-3.
Sebastian Kruggel, Thomas Lemcke

Arch Pharm (Weinheim)· June 2009

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9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication.
Hendrik Stukenbrock, Rainer Mussmann, Marcus Geese, Yoan Ferandin, Olivier Lozach, Thomas Lemcke

J Med Chem· April 2008

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Epoxide-containing side chains enhance antiproliferative activity of paullones.
Xu Xie, Thomas Lemcke, Rick Gussio, Daniel W Zaharevitz, Maryse Leost

Eur J Med Chem· July 2005

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Homology model of the CDK1/cyclin B complex.
Connor F McGrath, Nagarajan Pattabiraman, Glen E Kellogg, Thomas Lemcke, Conrad Kunick

J Biomol Struct Dyn· April 2005

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Structure-aided optimization of kinase inhibitors derived from alsterpaullone.
Conrad Kunick, Zhihong Zeng, Rick Gussio, Daniel Zaharevitz, Maryse Leost, Thomas Lemcke

Chembiochem· March 2005

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Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones.
Conrad Kunick, Kathrin Lauenroth, Karen Wieking, Xu Xie, Christiane Schultz, Thomas Lemcke

J Med Chem· January 2004

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1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.
Conrad Kunick, Kathrin Lauenroth, Maryse Leost, Laurent Meijer, Thomas Lemcke

Bioorg Med Chem Lett· January 2004

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