Publications by authors named "Thomas Mercher"

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Apoptosis-targeting BH3 mimetics: transforming treatment for patients with acute myeloid leukaemia.
Antonino Glaviano, Ellen Weisberg, Hiu Y Lam, Donavan J J Tan, Andrew J Innes, Thomas Mercher

Nat Rev Clin Oncol· November 2025

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GATA 2 much: stemness and resistance in AML chemotherapy.
Thomas Mercher, Marie-Laure Arcangeli

Blood· May 2025

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Oncogenomic profiling in infant-toddler T-ALL identifies NKX2 family genes as drivers linked to favorable outcomes.
Manon Delafoy, Estelle Balducci, Mathieu Simonin, Antoine Pinton, Guillaume Charbonnier, Thomas Mercher

Hemasphere· May 2025

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Progressive chromatin rewiring by ETO2::GLIS2 revealed in a genome-edited human iPSC model of pediatric leukemia initiation.
Fabien Boudia, Marie Baille, Loélia Babin, Zakia Aid, Elie Robert, Thomas Mercher

Blood· April 2025

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Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia.
Verónica Alonso-Pérez, Klaudia Galant, Fabien Boudia, Elie Robert, Zakia Aid, Thomas Mercher

Mol Cancer· September 2024

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Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia.
Shannon L Carey-Smith, Maryam H Simad, Kunjal Panchal, Carlos Aya-Bonilla, Hannah Smolders, Thomas Mercher

Haematologica· July 2024

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From hypoxia single-cell gene signatures to HIF targeting of AML leukemic stem cells.
Thomas Mercher, Juerg Schwaller

Hemasphere· March 2024

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A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.
Maria Eugénia Marques Da Costa, Sakina Zaidi, Jean-Yves Scoazec, Robin Droit, Wan Ching Lim, Thomas Mercher

Commun Biol· September 2023

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The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53.
Maria-Riera Piqué-Borràs, Zivojin Jevtic, Frederik Otzen Bagger, Jonathan Seguin, Rathick Sivalingam, Thomas Mercher

Blood· May 2023

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High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2::GLIS2 pediatric leukemia.
Zakia Aid, Elie Robert, Cécile K Lopez, Maxence Bourgoin, Fabien Boudia, Thomas Mercher

Leukemia· March 2023

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ERGonomics for EVI1 acute myeloid leukemia.
Cécile K Lopez, Thomas Mercher

Blood· February 2023

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ETS Fight Club on Microsatellite Enhancers.
Thomas Mercher

Blood Cancer Discov· January 2023

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Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model.
Brahim Arkoun, Elie Robert, Fabien Boudia, Stefania Mazzi, Virginie Dufour, Thomas Mercher

J Clin Invest· July 2022

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De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells.
Loélia Babin, Alice Darchen, Elie Robert, Zakia Aid, Rosalie Borry, Thomas Mercher

Mol Cancer· March 2022

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Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia.
Salima Benbarche, Cécile K Lopez, Eralda Salataj, Zakia Aid, Cécile Thirant, Thomas Mercher

Sci Adv· February 2022

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JAM-C/ Expression Is Primarily Expressed in Mouse Hematopoietic Stem Cells.
Elia Henry, Vilma Barroca, Cécile K Lopez, Michel Aurrand-Lions, Daniel Lewandowski, Thomas Mercher

Hemasphere· July 2021

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Molecular Landscapes and Models of Acute Erythroleukemia.
Alexandre Fagnan, Maria-Riera Piqué-Borràs, Samantha Tauchmann, Thomas Mercher, Juerg Schwaller

Hemasphere· May 2021

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Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers.
Alexandre Fagnan, Frederik Otzen Bagger, Maria-Riera Piqué-Borràs, Cathy Ignacimouttou, Alexis Caulier, Thomas Mercher

Blood· August 2020

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Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia.
Anouchka P Laurent, Aurélie Siret, Cathy Ignacimouttou, Kunjal Panchal, M'Boyba Diop, Thomas Mercher

Clin Cancer Res· July 2020

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and : usually the bride rather than the bridesmaid.
Alexandre Fagnan, Thomas Mercher

Haematologica· July 2020

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Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
Katharina Leonards, Marwa Almosailleakh, Samantha Tauchmann, Frederik Otzen Bagger, Cécile Thirant, Thomas Mercher

Nat Commun· June 2020

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Nfkbie-deficiency leads to increased susceptibility to develop B-cell lymphoproliferative disorders in aged mice.
Veronique Della-Valle, Damien Roos-Weil, Laurianne Scourzic, Enguerran Mouly, Zakia Aid, Thomas Mercher

Blood Cancer J· March 2020

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SPEN integrates transcriptional and epigenetic control of X-inactivation.
François Dossin, Inês Pinheiro, Jan J Żylicz, Julia Roensch, Samuel Collombet, Thomas Mercher

Nature· February 2020

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The Pediatric Acute Leukemia Fusion Oncogene ETO2-GLIS2 Increases Self-Renewal and Alters Differentiation in a Human Induced Pluripotent Stem Cells-Derived Model.
Salvatore Nicola Bertuccio, Fabien Boudia, Marie Cambot, Cécile K Lopez, Larissa Lordier, Thomas Mercher

Hemasphere· February 2020

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