Publications by authors named "Thomas Moench"

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Vaginally-delivered fast-dissolving antibody tablets (FDAT) for on-demand non-hormonal contraception and multi-purpose protection.
Keiichiro Kushiro, Scott Hammers, Yong Zhu, Haley B Flowers, Lauren Dawson, Thomas Moench

J Control Release· June 2025

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A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in healthy volunteers.
Thomas R Moench, Lakshmi Botta, Brian Farrer, Jason D Lickliter, Hyunah Kang

EBioMedicine· March 2025

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Inhaled "Muco-Trapping" Monoclonal Antibody Effectively Treats Established Respiratory Syncytial Virus (RSV) Infections.
Morgan D McSweeney, Sarhad Alnajjar, Alison M Schaefer, Zach Richardson, Whitney Wolf, Thomas R Moench

Adv Sci (Weinh)· March 2024

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ZB-06, a vaginal film containing an engineered human contraceptive antibody (HC4-N), demonstrates safety and efficacy in a phase 1 postcoital test and safety study.
Andrea R Thurman, Thomas R Moench, Marshall Hoke, Joseph A Politch, Howard Cabral

Am J Obstet Gynecol· June 2023

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LALAPG variant of the Human Contraception Antibody (HCA) reduces Fc-mediated effector functions while maintaining sperm agglutination activity.
Emilie Mausser, Ellena Nador, Joseph A Politch, Michael R Pauly, Jai G Marathe, Thomas R Moench

PLoS One· April 2023

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Hexavalent sperm-binding IgG antibody released from vaginal film for development of potent on-demand nonhormonal female contraception.
Bhawana Shrestha, Kathleen Vincent, Alison Schaefer, Yong Zhu, Gracie Vargas, Thomas R Moench

Proc Natl Acad Sci U S A· November 2021

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Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception.
Bhawana Shrestha, Alison Schaefer, Yong Zhu, Jamal Saada, Timothy M Jacobs, Thomas R Moench

Sci Transl Med· August 2021

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Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women.
Gabriela Baldeon-Vaca, Jai G Marathe, Joseph A Politch, Emilie Mausser, Jeffrey Pudney, Thomas R Moench

EBioMedicine· July 2021

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Safety, acceptability, and pharmacokinetics of a monoclonal antibody-based vaginal multipurpose prevention film (MB66): A Phase I randomized trial.
Joseph A Politch, Susan Cu-Uvin, Thomas R Moench, Karen T Tashima, Jai G Marathe

PLoS Med· February 2021

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Engineering tetravalent IgGs with enhanced agglutination potencies for trapping vigorously motile sperm in mucin matrix.
Bhawana Shrestha, Alison Schaefer, Elizabeth C Chavez, Alexander J Kopp, Timothy M Jacobs, Thomas R Moench

Acta Biomater· November 2020

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Engineering monoclonal antibody-based contraception and multipurpose prevention technologies†.
Deborah J Anderson, Joseph A Politch, Richard A Cone, Larry Zeitlin, Samuel K Lai, Thomas R Moench

Biol Reprod· August 2020

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The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis.
Thuy Hoang, Emily Toler, Kevin DeLong, Nomfuneko A Mafunda, Seth M Bloom, Thomas R Moench

PLoS Pathog· January 2020

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Vaginal pH measured in vivo: lactobacilli determine pH and lactic acid concentration.
Deirdre Elizabeth O'Hanlon, Richard A Come, Thomas R Moench

BMC Microbiol· January 2019

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Anti-HIV-1 Activity of Lactic Acid in Human Cervicovaginal Fluid.
David Tyssen, Ying-Ying Wang, Joshua A Hayward, Paul A Agius, Kevin DeLong, Thomas R Moench

mSphere· July 2018

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Comparison of the vaginal environment in rhesus and cynomolgus macaques pre- and post-lactobacillus colonization.
Gregory J Daggett, Chunxia Zhao, Fawn Connor-Stroud, Patricia Oviedo-Moreno, Hojin Moon, Thomas Moench

J Med Primatol· October 2017

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Attitudes and perceptions towards novel objective measures of ARV-based vaginal ring use: Results from a global stakeholder survey.
Randy M Stalter, Jenae Tharaldson, Derek H Owen, Eunice Okumu, Thomas Moench

PLoS One· September 2017

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Biomarkers and biometric measures of adherence to use of ARV-based vaginal rings.
Randy M Stalter, Thomas R Moench, Kathleen M MacQueen, Elizabeth E Tolley, Derek H Owen

J Int AIDS Soc· August 2017

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Pharmacokinetics and Preliminary Safety of Pod-Intravaginal Rings Delivering the Monoclonal Antibody VRC01-N for HIV Prophylaxis in a Macaque Model.
Chunxia Zhao, Manjula Gunawardana, Francois Villinger, Marc M Baum, Mariana Remedios-Chan, Thomas R Moench

Antimicrob Agents Chemother· July 2017

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Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus.
Christine E Henry, Ying-Ying Wang, Qi Yang, Thuy Hoang, Sumon Chattopadhyay, Thomas Moench

Acta Biomater· October 2016

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Enema ion compositions for enhancing colorectal drug delivery.
Katharina Maisel, Sumon Chattopadhyay, Thomas Moench, Craig Hendrix, Richard Cone

J Control Release· July 2015

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An interdisciplinary framework for measuring and supporting adherence in HIV prevention trials of ARV-based vaginal rings.
Kathleen M MacQueen, Elizabeth E Tolley, Derek H Owen, K Rivet Amico, Kathleen M Morrow, Thomas Moench

J Int AIDS Soc· May 2015

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Cell-associated transmission of HIV type 1 and other lentiviruses in small-animal models.
Thomas R Moench

J Infect Dis· December 2014

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Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota.
Deirdre E O'Hanlon, Thomas R Moench, Richard A Cone

PLoS One· June 2014

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Vaginal concentrations of lactic acid potently inactivate HIV.
Muriel Aldunate, David Tyssen, Adam Johnson, Tasnim Zakir, Secondo Sonza, Thomas Moench

J Antimicrob Chemother· September 2013

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