Publications by authors named "Thomas Roddy"

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Purine nucleotides are competitive inhibitors of apo-GOT1.
Narges Pourmandi, Arjun Jha, Kendall Muzzarelli, Hyunsu Lee, Zahra Assar, Thomas P Roddy

bioRxiv· September 2025

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ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses.
Irem Kaymak, McLane J Watson, Brandon M Oswald, Shixin Ma, Benjamin K Johnson, Thomas P Roddy

J Exp Med· September 2024

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C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells.
Eric H Ma, Michael S Dahabieh, Lisa M DeCamp, Irem Kaymak, Susan M Kitchen-Goosen, Thomas P Roddy

Sci Adv· May 2024

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C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells.
Eric H Ma, Michael S Dahabieh, Lisa M DeCamp, Irem Kaymak, Susan M Kitchen-Goosen, Thomas P Roddy

bioRxiv· June 2023

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Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer.
Sarah A Best, Patrick M Gubser, Shalini Sethumadhavan, Ariena Kersbergen, Yashira L Negrón Abril, Thomas P Roddy

Cell Metab· June 2022

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Rapid, Selective, and Sensitive Method for Semitargeted Discovery of Congeneric Natural Products by Liquid Chromatography Tandem Mass Spectrometry.
Kithsiri B Herath, Stephen F Previs, Thomas P Roddy, Athula B Attygalle, Ignacio González

J Nat Prod· March 2021

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Itaconate confers tolerance to late NLRP3 inflammasome activation.
Monika Bambouskova, Lucie Potuckova, Tomas Paulenda, Martina Kerndl, Denis A Mogilenko, Thomas P Roddy

Cell Rep· March 2021

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Preclinical toxicology profile of squalene epoxidase inhibitors.
Raj Nagaraja, Andrew Olaharski, Rohini Narayanaswamy, Christopher Mahoney, David Pirman, Thomas P Roddy

Toxicol Appl Pharmacol· August 2020

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Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages.
Amanda Swain, Monika Bambouskova, Hyeryun Kim, Prabhakar Sairam Andhey, Dustin Duncan, Thomas P Roddy

Nat Metab· July 2020

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Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
Dominic G Roy, Jocelyn Chen, Victoria Mamane, Eric H Ma, Brejnev M Muhire, Thomas P Roddy

Cell Metab· February 2020

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Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8 T Cells.
Eric H Ma, Mark J Verway, Radia M Johnson, Dominic G Roy, Mya Steadman, Thomas P Roddy

Immunity· November 2019

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A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition.
Christopher E Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Thomas Roddy

Nat Commun· January 2019

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Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.
Ian J Neeland, Shruti Singh, Darren K McGuire, Gloria L Vega, Thomas Roddy

Diabetologia· December 2018

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Using [H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies.
Stephen F Previs, Kithsiri Herath, Andrea R Nawrocki, Carlos G Rodriguez, Deborah Slipetz, Thomas P Roddy

Am J Physiol Endocrinol Metab· July 2018

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DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.
David G McLaren, Seongah Han, Beth Ann Murphy, Larissa Wilsie, Steven J Stout, Thomas P Roddy

Cell Metab· June 2018

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Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
Monika Bambouskova, Laurent Gorvel, Vicky Lampropoulou, Alexey Sergushichev, Ekaterina Loginicheva, Thomas P Roddy

Nature· April 2018

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Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers.
Natalie A Daurio, Sheng-Ping Wang, Ying Chen, Haihong Zhou, David G McLaren, Thomas P Roddy

J Pharmacol Exp Ther· October 2017

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CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects.
Tiffany Thomas, Haihong Zhou, Wahida Karmally, Rajasekhar Ramakrishnan, Stephen Holleran, Thomas Roddy

Arterioscler Thromb Vasc Biol· September 2017

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Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus.
Sheng-Ping Wang, Dan Zhou, Zuliang Yao, Santhosh Satapati, Ying Chen, Thomas P Roddy

Am J Physiol Endocrinol Metab· December 2016

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Plasma Levels of Risk-Variant APOL1 Do Not Associate with Renal Disease in a Population-Based Cohort.
Julia Kozlitina, Haihong Zhou, Patricia N Brown, Rory J Rohm, Yi Pan, Thomas P Roddy

J Am Soc Nephrol· October 2016

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Effect of Error Propagation in Stable Isotope Tracer Studies: An Approach for Estimating Impact on Apparent Biochemical Flux.
Stephen F Previs, Kithsiri Herath, Jose Castro-Perez, Ablatt Mahsut, Haihong Zhou, Thomas P Roddy

Methods Enzymol· June 2016

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Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.
David G McLaren, Stephen F Previs, Robert D Phair, Steven J Stout, Dan Xie, Thomas P Roddy

J Lipid Res· March 2016

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Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor.
Jinqi Liu, David G McLaren, Dunlu Chen, Yanqing Kan, Steven J Stout, Thomas P Roddy

Pharmacol Res Perspect· December 2015

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Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding.
Andreas L Marzinzik, René Amstutz, Guido Bold, Emmanuelle Bourgier, Simona Cotesta, Thomas P Roddy

ChemMedChem· November 2015

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Inhibition of cholesteryl ester transfer protein increases cholesteryl ester content of large HDL independently of HDL-to-HDL homotypic transfer: in vitro vs in vivo comparison using anacetrapib and dalcetrapib.
Douglas G Johns, Ying Chen, Sheng-Ping Wang, Jose Castro-Perez, Stephen F Previs, Thomas P Roddy

Eur J Pharmacol· September 2015

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