Publications by authors named "Thomas Ryll"

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Comprehensive manipulation of glycosylation profiles across development scales.
Sven Loebrich, Elisa Clark, Kristina Ladd, Stefani Takahashi, Anna Brousseau, Thomas Ryll

MAbs· July 2019

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Innovation in Cell Banking, Expansion, and Production Culture.
Rashmi Kshirsagar, Thomas Ryll

Adv Biochem Eng Biotechnol· May 2019

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The impact of trisulfide modification of antibodies on the properties of antibody-drug conjugates manufactured using thiol chemistry.
Renpeng Liu, Xuan Chen, Junia Dushime, Megan Bogalhas, Alexandru C Lazar, Thomas Ryll

MAbs· April 2017

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Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture.
Brandon N Berry, Terrence M Dobrowsky, Rebecca C Timson, Rashmi Kshirsagar, Thomas Ryll

Biotechnol Prog· November 2016

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A high-throughput capillary isoelectric focusing immunoassay for fingerprinting protein sialylation.
Lam Raga Anggara Markely, Lila Cheung, Young Jun Choi, Thomas Ryll, Scott Estes, Thomas Ryll

Biotechnol Prog· November 2016

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Application of high-throughput mini-bioreactor system for systematic scale-down modeling, process characterization, and control strategy development.
Vijay Janakiraman, Chris Kwiatkowski, Rashmi Kshirsagar, Thomas Ryll, Yao-Ming Huang

Biotechnol Prog· October 2016

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Integration of cell line and process development to overcome the challenge of a difficult to express protein.
Christina S Alves, Alan Gilbert, Swati Dalvi, Bryan St Germain, Wenqi Xie, Thomas Ryll

Biotechnol Prog· August 2016

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Concentrated fed-batch cell culture increases manufacturing capacity without additional volumetric capacity.
William C Yang, Daniel F Minkler, Rashmi Kshirsagar, Thomas Ryll, Yao-Ming Huang

J Biotechnol· January 2016

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Advanced process monitoring and feedback control to enhance cell culture process production and robustness.
An Zhang, Valerie Liu Tsang, Brandon Moore, Vivian Shen, Yao-Ming Huang, Thomas Ryll

Biotechnol Bioeng· December 2015

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Development of small scale cell culture models for screening poloxamer 188 lot-to-lot variation.
Haofan Peng, Kaitlyn M Hall, Blake Clayton, Kelly Wiltberger, Weiwei Hu, Thomas Ryll

Biotechnol Prog· August 2015

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Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality.
William C Yang, Jiuyi Lu, Chris Kwiatkowski, Hang Yuan, Rashmi Kshirsagar, Thomas Ryll

Biotechnol Prog· February 2015

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Application of bioreactor design principles and multivariate analysis for development of cell culture scale down models.
Lia Tescione, James Lambropoulos, Madhava Ram Paranandi, Helena Makagiansar, Thomas Ryll

Biotechnol Bioeng· January 2015

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High-throughput ion exchange purification of positively charged recombinant protein in the presence of negatively charged dextran sulfate.
Lam Raga A Markely, Lutfiye Kurt, Janet Lau, Sarthak Mane, Bing Guan, Thomas Ryll

Biotechnol Prog· December 2014

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Effects of bubble–liquid two-phase turbulent hydrodynamics on cell damage in sparged bioreactor.
Yang Liu, Fanxing Li, Weiwei Hu, Kelly Wiltberger, Thomas Ryll

Biotechnol Prog· September 2014

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Development of a scale down cell culture model using multivariate analysis as a qualification tool.
Valerie Liu Tsang, Angela X Wang, Helena Yusuf-Makagiansar, Thomas Ryll

Biotechnol Prog· September 2014

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Investigation of metabolic variability observed in extended fed batch cell culture.
Alan Gilbert, Kyle McElearney, Rashmi Kshirsagar, Martin S Sinacore, Thomas Ryll

Biotechnol Prog· August 2014

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Addition of valproic acid to CHO cell fed-batch cultures improves monoclonal antibody titers.
William C Yang, Jiuyi Lu, Ngan B Nguyen, An Zhang, Nicholas V Healy, Thomas Ryll

Mol Biotechnol· May 2014

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Confined synthesis and integration of functional materials in sub-nanoliter volumes.
Benjamin Z Cvetković, Josep Puigmartí-Luis, Daniel Schaffhauser, Thomas Ryll, Stefan Schmid

ACS Nano· January 2013

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Controlling trisulfide modification in recombinant monoclonal antibody produced in fed-batch cell culture.
Rashmi Kshirsagar, Kyle McElearney, Alan Gilbert, Marty Sinacore, Thomas Ryll

Biotechnol Bioeng· October 2012

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Novel cholesterol feeding strategy enables a high-density cultivation of cholesterol-dependent NS0 cells in linear low-density polyethylene-based disposable bioreactors.
Yiwen Tao, Helena Yusuf-Makagiansar, Jennifer Shih, Thomas Ryll, Marty Sinacore

Biotechnol Lett· August 2012

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Generation of a cholesterol-independent, non-GS NS0 cell line through chemical treatment and application for high titer antibody production.
Jincai Li, Wei Gu, Diane G Edmondson, Connie Lu, Natarajan Vijayasankaran, Thomas Ryll

Biotechnol Bioeng· July 2012

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Performance of high intensity fed-batch mammalian cell cultures in disposable bioreactor systems.
John Paul Smelko, Kelly Rae Wiltberger, Eric Francis Hickman, Beverly Janey Morris, Tobias James Blackburn, Thomas Ryll

Biotechnol Prog· February 2012

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Development and implementation of a perfusion-based high cell density cell banking process.
Yiwen Tao, Jennifer Shih, Marty Sinacore, Thomas Ryll, Helena Yusuf-Makagiansar

Biotechnol Prog· November 2011

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Dealloying of platinum-aluminum thin films: dynamics of pattern formation.
Henning Galinski, Thomas Ryll, Lukas Schlagenhauf, Felix Rechberger, Sun Ying

Phys Rev Lett· November 2011

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Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment.
Yao-Ming Huang, WeiWei Hu, Eddie Rustandi, Kevin Chang, Helena Yusuf-Makagiansar, Thomas Ryll

Biotechnol Prog· January 2011

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