Publications by authors named "Thomas T Perls"

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A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring.
Todd W Dowrey, Samuel F Cranston, Nicholas Skvir, Yvonne Lok, Brian Gould, Bradley Petrowitz, Daniel Villar, Jidong Shan, Marianne James, Mark Dodge

Aging Cell· January 2025

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The genetics of extreme longevity: lessons from the new England centenarian study.
Paola Sebastiani, Thomas T Perls

Front Genet· December 2012

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Linguistic Features from Paragraph Recall are Markers of Cognitive Impairment.
Seho Park, Nicole Roth, Megan Barker, Sanford Auerbach, Thomas T Perls

medRxiv· December 2025

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A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E.
Paola Sebastiani, Eric Reed, Kevin B Chandler, Prisma Lopez, Hannah Lords, Thomas T Perls

Adv Sci (Weinh)· November 2025

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The role of lipids in the effect of APOE2 on cognitive function: a causal mediation analysis.
Qingyan Xiang, Judith J Lok, Nicole Roth, Stacy L Andersen, Thomas T Perls

Eur J Epidemiol· October 2025

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IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures.
Todd W Dowrey, Samuel F Cranston, Nicholas J Skvir, Yvonne Lok, Payton Bock, Thomas T Perls

bioRxiv· October 2025

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Pathway analysis of cognitive resilience factors and cognitive function in the Long Life Family Study (LLFS).
Nicole Roth, Stephanie Cosentino, Thomas T Perls, Paola Sebastiani, Stacy L Andersen

Neuropsychology· September 2025

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Increased genetic protection against Alzheimer's disease in centenarians.
Harold Bae, Zeyuan Song, Amanat Ali, Takashi Sasaki, Niccolò Tesi, Thomas T Perls

Geroscience· July 2025

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Whole blood transcriptional signatures of age and survival identified in Long Life Family and Integrative Longevity Omics Studies.
Mengze Li, Zeyuan Song, Eric Reed, Tanya T Karagiannis, Stacy Andersen, Thomas T Perls

bioRxiv· July 2025

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SNP rs6543176 is associated with extreme human longevity but increased risk for cancer.
Anastasia Gurinovich, Zeyuan Song, Harold Bae, Anastasia Leshchyk, Mengze Li, Thomas T Perls

Geroscience· June 2025

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Increased Genetic Protection Against Alzheimer's Disease in Centenarians.
Harold Bae, Zeyuan Song, Amanat Ali, Takashi Sasaki, Niccolò Tesi, Thomas T Perls

bioRxiv· June 2025

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Evidence of a novel gene locus for longitudinal change in hemoglobin A1c levels among subjects without diabetes from the Long Life Family Study.
Siyu Wang, Petra Lenzini, Bharat Thyagarajan, Joseph H Lee, Badri N Vardarajan, Thomas T Perls

Physiol Genomics· May 2025

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Robust Serum Proteomic Signatures of APOE2.
Paola Sebastiani, Eric Reed, Kevin B Chandler, Prisma Lopez, Hannah Lords, Thomas T Perls

bioRxiv· May 2025

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Cross-platform proteomics signatures of extreme old age.
Eric R Reed, Kevin B Chandler, Prisma Lopez, Catherine E Costello, Stacy L Andersen, Thomas T Perls

Geroscience· February 2025

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Causal mediation analysis of the neuroprotection of through lipid pathways.
Qingyan Xiang, Judith J Lok, Nicole Roth, Stacy L Andersen, Thomas T Perls

medRxiv· January 2025

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All-Cause Mortality and Cause-Specific Death in U.S. Long-Lived Siblings: Data From the Long Life Family Study.
Shanshan Yao, Robert M Boudreau, Angéline Galvin, Joanne M Murabito, Lawrence S Honig, Thomas T Perls

J Gerontol A Biol Sci Med Sci· November 2024

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Metabolite signatures of chronological age, aging, survival, and longevity.
Paola Sebastiani, Stefano Monti, Michael S Lustgarten, Zeyuan Song, Dylan Ellis, Thomas T Perls

Cell Rep· November 2024

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A Novel Gene for Longitudinal Changes in Glycated Hemoglobin (HbA1c) in Subjects without Type 2 Diabetes: Evidence from the Long Life Family Study (LLFS) and the Framingham Offspring Study (FOS).
Siyu Wang, Petra Lenzini, Bharat Thygarajan, Joseph H Lee, Badri N Vardarajan, Thomas T Perls

bioRxiv· May 2024

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Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.
Laura Xicota, Stephanie Cosentino, Badri Vardarajan, Richard Mayeux, Thomas T Perls

Alzheimers Dement· April 2024

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Cross-platform proteomics signatures of extreme old age.
Eric R Reed, Kevin B Chandler, Prisma Lopez, Catherine E Costello, Stacy L Andersen, Thomas T Perls

bioRxiv· April 2024

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A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring.
Todd W Dowrey, Samuel F Cranston, Nicholas Skvir, Yvonne Lok, Brian Gould, Thomas T Perls

bioRxiv· March 2024

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Signatures of Neuropsychological Test Results in the Long Life Family Study: A Cluster Analysis.
Qingyan Xiang, Stacy L Andersen, Benjamin Sweigart, Sophia Gunn, Marianne Nygaard, Thomas T Perls

J Alzheimers Dis· October 2023

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Mosaic Chromosomal Alterations and Human Longevity.
Anastasia Leshchyk, Qingyan Xiang, Stacy L Andersen, Anastasia Gurinovich, Zeyuan Song, Thomas T Perls

J Gerontol A Biol Sci Med Sci· August 2023

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Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity.
Tanya T Karagiannis, Todd W Dowrey, Carlos Villacorta-Martin, Monty Montano, Eric Reed, Thomas T Perls

EBioMedicine· April 2023

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A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants.
Harold Bae, Anastasia Gurinovich, Tanya T Karagiannis, Zeyuan Song, Anastasia Leshchyk, Thomas T Perls

Int J Mol Sci· December 2022

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Evaluation of GENESIS, SAIGE, REGENIE and fastGWA-GLMM for genome-wide association studies of binary traits in correlated data.
Anastasia Gurinovich, Mengze Li, Anastasia Leshchyk, Harold Bae, Zeyuan Song, Thomas T Perls

Front Genet· September 2022

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