Publications by authors named "Thomas Utley"

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Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4).
Emery Smith, Peter Chase, Colleen M Niswender, Thomas J Utley, Douglas J Sheffler

J Biomol Screen· August 2015

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Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.
Nidhi Jalan-Sakrikar, Julie R Field, Rebecca Klar, Margrith E Mattmann, Karen J Gregory, Thomas J Utley

ACS Chem Neurosci· December 2014

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Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe.
Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, Hyekyung P Cho, Emery Smith, Thomas J Utley

ChemMedChem· August 2014

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Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency.
John T Bates, Christopher J Keefer, Thomas J Utley, Bruno E Correia, William R Schief

J Immunol· April 2013

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Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.
Michael S Poslusney, Bruce J Melancon, Patrick R Gentry, Douglas J Sheffler, Thomas M Bridges, Thomas J Utley

Bioorg Med Chem Lett· March 2013

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Respiratory syncytial virus assembles into structured filamentous virion particles independently of host cytoskeleton and related proteins.
Fyza Y Shaikh, Thomas J Utley, Ryan E Craven, Meredith C Rogers, Lynne A Lapierre

PLoS One· January 2013

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Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
Uyen Le, Bruce J Melancon, Thomas M Bridges, Paige N Vinson, Thomas J Utley

Bioorg Med Chem Lett· January 2013

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Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule.
Bruce J Melancon, Michael S Poslusney, Patrick R Gentry, James C Tarr, Douglas J Sheffler, Thomas J Utley

Bioorg Med Chem Lett· January 2013

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Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.
Gregory J Digby, Thomas J Utley, Atin Lamsal, Christian Sevel, Douglas J Sheffler

ACS Chem Neurosci· December 2012

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Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists.
Michael S Poslusney, Christian Sevel, Thomas J Utley, Thomas M Bridges, Ryan D Morrison

Bioorg Med Chem Lett· November 2012

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Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.
James C Tarr, Mark L Turlington, Paul R Reid, Thomas J Utley, Douglas J Sheffler

ACS Chem Neurosci· November 2012

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Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor.
James M Salovich, Paige N Vinson, Douglas J Sheffler, Atin Lamsal, Thomas J Utley

Bioorg Med Chem Lett· August 2012

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Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012.
Bruce J Melancon, Thomas J Utley, Christian Sevel, Margrith E Mattmann, Yiu-Yin Cheung

Bioorg Med Chem Lett· August 2012

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Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
Gregory J Digby, Meredith J Noetzel, Michael Bubser, Thomas J Utley, Adam G Walker

J Neurosci· June 2012

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Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.
Bruce J Melancon, Rocco D Gogliotti, James C Tarr, Sam A Saleh, Brian A Chauder, Thomas J Utley

Bioorg Med Chem Lett· May 2012

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Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1.
Rene Raphemot, Daniel F Lonergan, Thuy T Nguyen, Thomas Utley, L Michelle Lewis

Front Pharmacol· March 2012

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Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012.
Bruce J Melancon, Alexander P Lamers, Thomas M Bridges, Gary A Sulikowski, Thomas J Utley

Bioorg Med Chem Lett· January 2012

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Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.
Thomas Utley, Dustin Haddenham, James M Salovich, Rocio Zamorano, Paige N Vinson

Bioorg Med Chem Lett· December 2011

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Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication.
Michael E Lindquist, Aaron W Lifland, Thomas J Utley, Philip J Santangelo, James E Crowe

J Virol· December 2010

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Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation.
Aaron Derdowski, Timothy R Peters, Nancy Glover, Ray Qian, Thomas J Utley

J Gen Virol· November 2008

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Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2.
Thomas J Utley, Nicole A Ducharme, Vasundhara Varthakavi, Bryan E Shepherd, Philip J Santangelo

Proc Natl Acad Sci U S A· July 2008

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