Publications by authors named "Thomas Wein"

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Tailored SirReal-type inhibitors enhance SIRT2 inhibition through ligand stabilization and disruption of NAD co-factor binding.
Ricky Wirawan, Matthias Frei, Anna Heider, Niklas Papenkordt, Florian Friedrich, Thomas Wein

RSC Med Chem· November 2025

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Lead Structure-Based Hybridization Strategy Reveals Major Potency Enhancement of SirReal-Type Sirt2 Inhibitors.
Matthias Frei, Ricky Wirawan, Thomas Wein, Franz Bracher

Int J Mol Sci· October 2025

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Balsalazide-Derived Heterotriaryls as Sirtuin 5 Inhibitors: A Case Study of a Reversible Covalent Inhibition Strategy.
Ricky Wirawan, Simon A Huber, Thomas Wein, Franz Bracher

Molecules· September 2025

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Development of an RXR Agonist Scaffold with Pronounced Homodimer Preference.
Felix Nawa, Arthur Kardanov, Till Kasch, Max Lewandowski, Thomas Wein

J Med Chem· August 2025

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Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design.
Úrsula López-García, Jan Vietor, Julian A Marschner, Jan Heering, Vasily Morozov, Thomas Wein

Commun Chem· May 2025

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Lead-Structure-Based Rigidization Approach to Optimize SirReal-Type Sirt2 Inhibitors.
Matthias Frei, Thomas Wein, Franz Bracher

Molecules· April 2025

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A Nurr1 Agonist Derived from the Natural Ligand DHI Induces Neuroprotective Gene Expression.
Markus Egner, Romy Busch, Úrsula López-García, Max Lewandowski, Georg Höfner, Thomas Wein

J Med Chem· February 2025

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A High-Quality Photoswitchable Probe that Selectively and Potently Regulates the Transcription Factor RORγ.
Martin Reynders, Sabine Willems, Julian A Marschner, Thomas Wein, Daniel Merk

Angew Chem Int Ed Engl· December 2024

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Tuning RXR Modulators for PGC1α Recruitment.
Felix Nawa, Minh Sai, Jan Vietor, Roman Schwarzenbach, Anesa Bitić, Thomas Wein

J Med Chem· September 2024

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Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole.
Minh Sai, Jan Vietor, Moritz Kornmayer, Markus Egner, Úrsula López-García, Thomas Wein

J Med Chem· October 2023

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Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands.
Silvia Arifi, Daniel Zaienne, Jan Heering, Thomas Wein, Rezart Zhubi

Bioorg Chem· December 2022

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Self-reporting styrylthiazolium photopharmaceuticals: mitochondrial localisation as well as SAR drive biological activity.
Li Gao, Yvonne Kraus, Andrea Stegner, Thomas Wein, Constanze Heise

Org Biomol Chem· October 2022

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[Is Mandatory Vaccination Against the Coronavirus Necessary?].
Thomas Wein

Wirtschaftsdienst· February 2021

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New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling.
Thomas Wein, Klaus T Wanner, Sebastian Rappenglück, Sonja Sichler, Karin V Niessen

Curr Comput Aided Drug Des· April 2019

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Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
Sebastian Rappenglück, Sonja Sichler, Georg Höfner, Thomas Wein, Karin V Niessen

ChemMedChem· December 2018

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Novel Allosteric Ligands of γ-Aminobutyric Acid Transporter 1 (GAT1) by MS Based Screening of Pseudostatic Hydrazone Libraries.
Tobias J Hauke, Thomas Wein, Georg Höfner, Klaus T Wanner

J Med Chem· November 2018

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Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
Thomas Wein, Georg Höfner, Sebastian Rappenglück, Sonja Sichler, Karin V Niessen

Toxicol Lett· September 2018

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Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.
Sebastian Rappenglück, Sonja Sichler, Georg Höfner, Thomas Wein, Karin V Niessen

ChemMedChem· September 2018

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Development of New Photoswitchable Azobenzene Based γ-Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon Photoactivation.
Toni Lutz, Thomas Wein, Georg Höfner, Jörg Pabel, Matthias Eder

J Med Chem· July 2018

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Overcoming resistance against managed care - insights from a bargaining model.
Andree Ehlert, Thomas Wein, Peter Zweifel

Health Econ Rev· December 2017

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Biceps Femoris Injury a Rarity: A Case Report.
Roland Strasser, Thomas Wein, Marc Wieder, Johannes Erhardt, Jörg Kaufmann

Surg J (N Y)· July 2017

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Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives with N-Arylalkynyl Substituents.
Toni Lutz, Thomas Wein, Georg Höfner, Klaus T Wanner

ChemMedChem· March 2017

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Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.
Tim Hellenbrand, Georg Höfner, Thomas Wein, Klaus T Wanner

Bioorg Med Chem· May 2016

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Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions.
Marilena Petrera, Thomas Wein, Lars Allmendinger, Miriam Sindelar, Jörg Pabel

ChemMedChem· March 2016

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Different Binding Modes of Small and Large Binders of GAT1.
Thomas Wein, Marilena Petrera, Lars Allmendinger, Georg Höfner, Jörg Pabel

ChemMedChem· March 2016

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