Publications by authors named "Jan Heering"

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Optimization and Evaluation of Complementary Degrader Discovery Assays for Application in Screening.
Johanna Huchting, Arjen Weller, Moyra Schweizer, Mona Brandt, Jan Heering

ACS Pharmacol Transl Sci· August 2025

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Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase.
Julia Schönfeld, Steffen Brunst, Ludmila Ciomirtan, Lena Willmer, Michel A Chromik, Jan Heering

J Med Chem· July 2025

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A First-in-Class Hepatocyte Nuclear Factor 4 Agonist.
Espen Schallmayer, Vasily Morozov, Silke Duensing-Kropp, Lasse Schallmayer, Leann Schüffner, Jan Heering

J Med Chem· May 2025

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Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design.
Úrsula López-García, Jan Vietor, Julian A Marschner, Jan Heering, Vasily Morozov

Commun Chem· May 2025

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Fragment-Based Discovery of Drug-like LRH-1 Agonists.
Alisa Lang, Niklas Ildefeld, Felix F Lillich, Astrid Kaiser, Romy Busch, Jan Heering

ACS Med Chem Lett· April 2025

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S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation.
Fiona K Sailer, Megan A Palmer, Blerina Aliraj, Jan Heering, Andreas Brockmann

Front Pharmacol· April 2025

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The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors.
Tom Teichmann, Beatrice Pflüger-Müller, Virna Margarita Martín Giménez, Fiona Sailer, Henrik Dirks, Jan Heering

Br J Pharmacol· March 2025

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Fatty Acid Mimetic Fragments as Liver Receptor Homologue-1 Modulators.
Alisa Lang, Tanja Stiller, Niklas Ildefeld, Pascal Heitel, Laura Isigkeit, Jan Heering

ACS Pharmacol Transl Sci· March 2025

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Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling.
Jeonghyeon Kwon, Haruya Kawase, Kenny Mattonet, Stefan Guenther, Lisa Hahnefeld, Jan Heering

Nat Commun· February 2025

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Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping.
Victor Hernandez-Olmos, Jan Heering, Niklas Ildefeld, Johanna H M Ehrler, Alexander Kaps

J Med Chem· January 2025

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Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets.
Martin P Schwalm, Johannes Dopfer, Adarsh Kumar, Francesco A Greco, Nicolas Bauer, Jan Heering

Nat Commun· November 2024

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SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor.
Mohamad Wessam Alnouri, Kenneth Anthony Roquid, Rémy Bonnavion, Haaglim Cho, Jan Heering

Proc Natl Acad Sci U S A· October 2024

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Tuning RXR Modulators for PGC1α Recruitment.
Felix Nawa, Minh Sai, Jan Vietor, Roman Schwarzenbach, Anesa Bitić, Jan Heering

J Med Chem· September 2024

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Oleic acid released by sensory neurons inhibits TRPV1-mediated thermal hypersensitivity via GPR40.
Maksim Sendetski, Saskia Wedel, Kenta Furutani, Lisa Hahnefeld, Carlo Angioni, Jan Heering

iScience· August 2024

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Development of a Potent and Selective G2A (GPR132) Agonist.
Victor Hernandez-Olmos, Jan Heering, Beatrice Marinescu, Tina Schermeng, Vladimir V Ivanov

J Med Chem· July 2024

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HTRF-based assay for detection of mono-ADP-ribosyl hydrolyzing macrodomains and inhibitor screening.
Niklas Ildefeld, Dieter Steinhilber, Ewgenij Proschak, Jan Heering

iScience· July 2024

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Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.
Annika Balzulat, W Felix Zhu, Cathrin Flauaus, Victor Hernandez-Olmos, Jan Heering

Adv Sci (Weinh)· April 2024

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Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation.
Silvia Arifi, Julian A Marschner, Julius Pollinger, Laura Isigkeit, Pascal Heitel, Jan Heering

J Am Chem Soc· July 2023

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Fragment-based discovery of orphan nuclear receptor Nur77/NGFI-B ligands.
Silvia Arifi, Daniel Zaienne, Jan Heering, Thomas Wein, Rezart Zhubi

Bioorg Chem· December 2022

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Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators.
Jan Heering, Nathalie Jores, Whitney Kilu, Espen Schallmayer, Evelyn Peelen

ACS Chem Biol· November 2022

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Compilation and evaluation of a fatty acid mimetics screening library.
Johanna H M Ehrler, Steffen Brunst, Amelie Tjaden, Whitney Kilu, Jan Heering

Biochem Pharmacol· October 2022

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Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR-1) Reveals Inverse NOR-1 Agonists.
Daniel Zaienne, Silvia Arifi, Julian A Marschner, Jan Heering, Daniel Merk

ChemMedChem· August 2022

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Nurr1 Modulation Mediates Neuroprotective Effects of Statins.
Sabine Willems, Julian A Marschner, Whitney Kilu, Giuseppe Faudone, Romy Busch, Jan Heering

Adv Sci (Weinh)· June 2022

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Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries.
Sabine Willems, Marcel Müller, Julia Ohrndorf, Jan Heering, Ewgenij Proschak

ChemMedChem· April 2022

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Development and Characterization of a Fluorescent Ligand for Leukotriene B4 Receptor 2 in Cells and Tissues.
Jan Heering, Victor Hernandez-Olmos, Niklas Ildefeld, Ting Liu, Anja Kaiser

J Med Chem· February 2022

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