Publications by authors named "Pascal Heitel"

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Scaffold Fusion and SAR Transfer with a Chemical Language Model Generates Novel Liver X Receptor Modulators.
Nils Christiaan Bandomir, Tim Hörmann, Annette Kärcher, Astrid Kaiser, Daniel Merk, Pascal Heitel

J Med Chem· November 2025

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Fatty Acid Mimetic Fragments as Liver Receptor Homologue-1 Modulators.
Alisa Lang, Tanja Stiller, Niklas Ildefeld, Pascal Heitel, Laura Isigkeit

ACS Pharmacol Transl Sci· March 2025

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Screening of Chelidonium majus isoquinoline alkaloids reveals berberine and chelidonine as selective ligands for the nuclear receptors RORβ and HNF4α, respectively.
Sohrab Salehi, Espen Schallmayer, Nils Bandomir, Annette Kärcher, Jan-Frederik Güth, Pascal Heitel

Arch Pharm (Weinheim)· July 2024

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Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation.
Silvia Arifi, Julian A Marschner, Julius Pollinger, Laura Isigkeit, Pascal Heitel

J Am Chem Soc· July 2023

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Emerging TACnology: Heterobifunctional Small Molecule Inducers of Targeted Posttranslational Protein Modifications.
Pascal Heitel

Molecules· January 2023

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Biosynthesis of prostaglandin 15dPGJ -glutathione and 15dPGJ-cysteine conjugates in macrophages and mast cells via MGST3.
Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Pascal Heitel

J Lipid Res· December 2022

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The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines.
Giuseppe Faudone, Whitney Kilu, Xiaomin Ni, Apirat Chaikuad, Sridhar Sreeramulu, Pascal Heitel

ACS Pharmacol Transl Sci· December 2021

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Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain.
Michael Brand, James Clayton, Mustafa Moroglu, Matthias Schiedel, Sarah Picaud, Pascal Heitel

J Med Chem· July 2021

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A triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice.
Pascal Heitel, Giuseppe Faudone, Moritz Helmstädter, Jurema Schmidt, Astrid Kaiser

Commun Chem· November 2020

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Design and Structural Optimization of Dual FXR/PPARδ Activators.
Simone Schierle, Sebastian Neumann, Pascal Heitel, Sabine Willems, Astrid Kaiser

J Med Chem· August 2020

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l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ.
Leonie Gellrich, Pascal Heitel, Jan Heering, Whitney Kilu, Julius Pollinger

J Med Chem· July 2020

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Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast.
Simone Schierle, Moritz Helmstädter, Jurema Schmidt, Markus Hartmann, Maximiliane Horz, Pascal Heitel

ChemMedChem· January 2020

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A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.
Julius Pollinger, Simone Schierle, Leonie Gellrich, Julia Ohrndorf, Astrid Kaiser, Pascal Heitel

ACS Med Chem Lett· September 2019

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Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype.
Pascal Heitel, Leonie Gellrich, Lena Kalinowsky, Jan Heering, Astrid Kaiser

ACS Med Chem Lett· February 2019

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Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro.
Pascal Heitel, Leonie Gellrich, Jan Heering, Tamara Goebel, Astrid Kahnt

Sci Rep· September 2018

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Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.
Simone Schierle, Cathrin Flauaus, Pascal Heitel, Sabine Willems, Jurema Schmidt

J Med Chem· July 2018

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Nonacidic Farnesoid X Receptor Modulators.
Daniel Flesch, Sun-Yee Cheung, Jurema Schmidt, Matthias Gabler, Pascal Heitel

J Med Chem· August 2017

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Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.
Ewgenij Proschak, Pascal Heitel, Lena Kalinowsky, Daniel Merk

J Med Chem· July 2017

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DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators.
Pascal Heitel, Janosch Achenbach, Daniel Moser, Ewgenij Proschak, Daniel Merk

Bioorg Med Chem Lett· March 2017

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