Publications by authors named "Astrid Kaiser"

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Scaffold Fusion and SAR Transfer with a Chemical Language Model Generates Novel Liver X Receptor Modulators.
Nils Christiaan Bandomir, Tim Hörmann, Annette Kärcher, Astrid Kaiser, Daniel Merk

J Med Chem· November 2025

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Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase.
Julia Schönfeld, Steffen Brunst, Ludmila Ciomirtan, Lena Willmer, Michel A Chromik, Astrid Kaiser

J Med Chem· July 2025

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Fragment-Based Discovery of Drug-like LRH-1 Agonists.
Alisa Lang, Niklas Ildefeld, Felix F Lillich, Astrid Kaiser, Romy Busch

ACS Med Chem Lett· April 2025

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A Photochemical Strategy towards Michael Addition Reactions of Cyclopropenes.
Yaseen Hussain, Prasanna R, Claire Empel, Deepak Sharma, Lennard Kloene, Astrid Kaiser

Angew Chem Int Ed Engl· January 2025

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Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping.
Victor Hernandez-Olmos, Jan Heering, Niklas Ildefeld, Johanna H M Ehrler, Alexander Kaps, Astrid Kaiser

J Med Chem· January 2025

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Development of a Potent and Selective G2A (GPR132) Agonist.
Victor Hernandez-Olmos, Jan Heering, Beatrice Marinescu, Tina Schermeng, Vladimir V Ivanov, Astrid Kaiser

J Med Chem· July 2024

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Efficacy of MP1032 in hospitalised patients with COVID-19- authors' reply.
Petra Sager, Astrid Kaiser, Sara Schumann, Beate Ludescher, Wolfgang Brysch

Lancet Reg Health Eur· March 2024

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Development of Selective Pyrido[2,3-]pyrimidin-7(8)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors.
Marcel Rak, Amelie Menge, Roberta Tesch, Lena M Berger, Dimitrios-Ilias Balourdas, Astrid Kaiser

J Med Chem· March 2024

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Efficacy and safety of MP1032 plus standard-of-care compared to standard-of-care in hospitalised patients with COVID-19: a multicentre, randomised double-blind, placebo-controlled phase 2a trial.
Petra Sager, Astrid Kaiser, Sara Schumann, Beate Ludescher, Michael Niedermaier

Lancet Reg Health Eur· February 2024

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Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3.
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Astrid Kaiser

J Med Chem· January 2024

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Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation.
Silvia Arifi, Julian A Marschner, Julius Pollinger, Laura Isigkeit, Pascal Heitel, Astrid Kaiser

J Am Chem Soc· July 2023

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Discovery of 3-Amino-1-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family.
Jennifer Alisa Amrhein, Lena Marie Berger, Amelie Tjaden, Andreas Krämer, Lewis Elson, Astrid Kaiser

Int J Mol Sci· November 2022

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Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors.
Felix F Lillich, Sabine Willems, Xiaomin Ni, Whitney Kilu, Carmen Borkowsky, Astrid Kaiser

J Med Chem· December 2021

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Second-Generation Dual FXR/sEH Modulators with Optimized Pharmacokinetics.
Moritz Helmstädter, Astrid Kaiser, Steffen Brunst, Jurema Schmidt, Riccardo Ronchetti

J Med Chem· July 2021

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Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells.
Giuseppe Faudone, Iris Bischoff-Kont, Lea Rachor, Sabine Willems, Rezart Zhubi, Astrid Kaiser

J Med Chem· June 2021

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Differential Therapeutic Effects of FXR Activation, sEH Inhibition, and Dual FXR/sEH Modulation in NASH in Diet-Induced Obese Mice.
Moritz Helmstädter, Jurema Schmidt, Astrid Kaiser, Lilia Weizel, Ewgenij Proschak

ACS Pharmacol Transl Sci· April 2021

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A New FXR Ligand Chemotype with Agonist/Antagonist Switch.
Moritz Helmstädter, Jan Vietor, Jana Sommer, Simone Schierle, Sabine Willems, Astrid Kaiser

ACS Med Chem Lett· February 2021

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A triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice.
Pascal Heitel, Giuseppe Faudone, Moritz Helmstädter, Jurema Schmidt, Astrid Kaiser

Commun Chem· November 2020

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Immune-Modulating Drug MP1032 with SARS-CoV-2 Antiviral Activity In Vitro: A potential Multi-Target Approach for Prevention and Early Intervention Treatment of COVID-19.
Sara Schumann, Astrid Kaiser, Ferdinando Nicoletti, Katia Mangano, Paolo Fagone

Int J Mol Sci· November 2020

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First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters.
Victor Hernandez-Olmos, Jan Heering, Viktoria Planz, Ting Liu, Alexander Kaps, Astrid Kaiser

J Med Chem· October 2020

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Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase.
Kerstin Hiesinger, Jan S Kramer, Sandra Beyer, Timon Eckes, Steffen Brunst, Astrid Kaiser

J Med Chem· October 2020

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Design and Structural Optimization of Dual FXR/PPARδ Activators.
Simone Schierle, Sebastian Neumann, Pascal Heitel, Sabine Willems, Astrid Kaiser

J Med Chem· August 2020

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Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast.
Simone Schierle, Moritz Helmstädter, Jurema Schmidt, Markus Hartmann, Maximiliane Horz, Astrid Kaiser

ChemMedChem· January 2020

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Structure optimization of a new class of PPARγ antagonists.
Victor Hernandez-Olmos, Tilo Knape, Jan Heering, Andreas von Knethen, Whitney Kilu, Astrid Kaiser

Bioorg Med Chem· November 2019

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A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.
Julius Pollinger, Simone Schierle, Leonie Gellrich, Julia Ohrndorf, Astrid Kaiser

ACS Med Chem Lett· September 2019

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