Publications by authors named "Simone Schierle"

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Activity Screening of Fatty Acid Mimetic Drugs Identified Nuclear Receptor Agonists.
Moritz Helmstädter, Simone Schierle, Laura Isigkeit, Ewgenij Proschak, Julian Aurelio Marschner

Int J Mol Sci· September 2022

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Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors.
Felix F Lillich, Sabine Willems, Xiaomin Ni, Whitney Kilu, Carmen Borkowsky, Simone Schierle

J Med Chem· December 2021

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Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1.
Daniel Zaienne, Sabine Willems, Simone Schierle, Jan Heering, Daniel Merk

J Med Chem· October 2021

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Development and in vitro Profiling of Dual FXR/LTA4H Modulators.
Simone Schierle, Steffen Brunst, Moritz Helmstädter, Roland Ebert, Jan S Kramer

ChemMedChem· August 2021

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Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.
Simone Schierle, Apirat Chaikuad, Felix F Lillich, Xiaomin Ni, Stefano Woltersdorf

J Med Chem· April 2021

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A New FXR Ligand Chemotype with Agonist/Antagonist Switch.
Moritz Helmstädter, Jan Vietor, Jana Sommer, Simone Schierle, Sabine Willems

ACS Med Chem Lett· February 2021

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A triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice.
Pascal Heitel, Giuseppe Faudone, Moritz Helmstädter, Jurema Schmidt, Astrid Kaiser, Simone Schierle

Commun Chem· November 2020

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Design and Structural Optimization of Dual FXR/PPARδ Activators.
Simone Schierle, Sebastian Neumann, Pascal Heitel, Sabine Willems, Astrid Kaiser

J Med Chem· August 2020

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A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode.
Thomas Hanke, Sun-Yee Cheung, Whitney Kilu, Jan Heering, Xiaomin Ni, Simone Schierle

J Med Chem· May 2020

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Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast.
Simone Schierle, Moritz Helmstädter, Jurema Schmidt, Markus Hartmann, Maximiliane Horz

ChemMedChem· January 2020

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A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.
Julius Pollinger, Simone Schierle, Leonie Gellrich, Julia Ohrndorf, Astrid Kaiser

ACS Med Chem Lett· September 2019

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Therapeutic modulation of retinoid X receptors - SAR and therapeutic potential of RXR ligands and recent patents.
Simone Schierle, Daniel Merk

Expert Opin Ther Pat· August 2019

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Computer-Assisted Selective Optimization of Side-Activities-from Cinalukast to a PPARα Modulator.
Julius Pollinger, Simone Schierle, Sebastian Neumann, Julia Ohrndorf, Astrid Kaiser

ChemMedChem· July 2019

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Development of Nuclear Receptor Modulators.
Simone Schierle, Daniel Merk

Methods Mol Biol· March 2019

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Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.
Julius Pollinger, Leonie Gellrich, Simone Schierle, Whitney Kilu, Jurema Schmidt

J Med Chem· February 2019

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Selective Optimization of Pranlukast to Farnesoid X Receptor Modulators.
Simone Schierle, Jurema Schmidt, Astrid Kaiser, Daniel Merk

ChemMedChem· December 2018

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Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists.
Jurema Schmidt, Simone Schierle, Leonie Gellrich, Astrid Kaiser, Daniel Merk

Bioorg Med Chem· August 2018

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Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.
Simone Schierle, Cathrin Flauaus, Pascal Heitel, Sabine Willems, Jurema Schmidt

J Med Chem· July 2018

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