Publications by authors named "Tilman Flock"

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Multiple intramolecular triggers converge to preferential G protein coupling in the CBR.
Adrian Morales-Pastor, Tamara Miljuš, Miguel Dieguez-Eceolaza, Tomasz Maciej Stępniewski, Vicente Ledesma-Martin, Tilman Flock

Nat Commun· June 2025

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Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants.
Bianca Plouffe, Angeliki Karamitri, Tilman Flock, Jonathan M Gallion, Shane Houston

ACS Pharmacol Transl Sci· February 2022

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Molecular determinants underlying functional innovations of TBP and their impact on transcription initiation.
Charles N J Ravarani, Tilman Flock, Sreenivas Chavali, Madhanagopal Anandapadamanaban, M Madan Babu

Nat Commun· May 2020

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Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit.
Ching-Ju Tsai, Jacopo Marino, Ricardo Adaixo, Filip Pamula, Jonas Muehle, Tilman Flock

Elife· June 2019

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Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation.
Daniel Mayer, Fred F Damberger, Mamidi Samarasimhareddy, Miki Feldmueller, Ziva Vuckovic, Tilman Flock

Nat Commun· March 2019

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An online resource for GPCR structure determination and analysis.
Christian Munk, Eshita Mutt, Vignir Isberg, Louise F Nikolajsen, Janne M Bibbe, Tilman Flock

Nat Methods· February 2019

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Crystal structure of rhodopsin in complex with a mini-G sheds light on the principles of G protein selectivity.
Ching-Ju Tsai, Filip Pamula, Rony Nehmé, Jonas Mühle, Tobias Weinert, Tilman Flock

Sci Adv· September 2018

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Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish.
Elliot Gerrard, Eshita Mutt, Takashi Nagata, Mitsumasa Koyanagi, Tilman Flock

Proc Natl Acad Sci U S A· June 2018

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Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation.
Andrija Sente, Raphael Peer, Ashish Srivastava, Mithu Baidya, Arthur M Lesk, Tilman Flock

Nat Struct Mol Biol· June 2018

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Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins.
Eviatar Natan, Tamaki Endoh, Liora Haim-Vilmovsky, Tilman Flock, Guilhem Chalancon

Nat Struct Mol Biol· March 2018

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Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas.
Melis Kayikci, A J Venkatakrishnan, James Scott-Brown, Charles N J Ravarani, Tilman Flock

Nat Struct Mol Biol· February 2018

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Exploiting sequence and stability information for directing nanobody stability engineering.
Patrick Kunz, Tilman Flock, Nicolas Soler, Moritz Zaiss, Cécile Vincke

Biochim Biophys Acta Gen Subj· September 2017

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Selectivity determinants of GPCR-G-protein binding.
Tilman Flock, Alexander S Hauser, Nadia Lund, David E Gloriam, Santhanam Balaji

Nature· May 2017

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Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region.
A J Venkatakrishnan, Xavier Deupi, Guillaume Lebon, Franziska M Heydenreich, Tilman Flock

Nature· August 2016

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Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer.
Natasha S Latysheva, Matt E Oates, Louis Maddox, Tilman Flock, Julian Gough

Mol Cell· August 2016

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Probing Gαi1 protein activation at single-amino acid resolution.
Dawei Sun, Tilman Flock, Xavier Deupi, Shoji Maeda, Milos Matkovic

Nat Struct Mol Biol· September 2015

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Universal allosteric mechanism for Gα activation by GPCRs.
Tilman Flock, Charles N J Ravarani, Dawei Sun, A J Venkatakrishnan, Melis Kayikci

Nature· August 2015

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How do disordered regions achieve comparable functions to structured domains?
Natasha S Latysheva, Tilman Flock, Robert J Weatheritt, Sreenivas Chavali, M Madan Babu

Protein Sci· June 2015

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Structured and disordered facets of the GPCR fold.
A J Venkatakrishnan, Tilman Flock, Daniel Estévez Prado, Matt E Oates, Julian Gough

Curr Opin Struct Biol· August 2014

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Controlling entropy to tune the functions of intrinsically disordered regions.
Tilman Flock, Robert J Weatheritt, Natasha S Latysheva, M Madan Babu

Curr Opin Struct Biol· June 2014

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General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH.
Sabine Brinkmann-Chen, Tilman Flock, Jackson K B Cahn, Christopher D Snow, Eric M Brustad

Proc Natl Acad Sci U S A· July 2013

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Deciphering membrane protein structures from protein sequences.
Tilman Flock, A J Venkatakrishnan, K R Vinothkumar, M Madan Babu

Genome Biol· June 2012

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