Publications by authors named "Tim Ahfeldt"

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Genetically encoded and modular subcellular organelle probes reveal dysfunction in lysosomes and mitochondria driven by PRKN knockout.
Camille Goldman, Tatyana Kareva, Lily Sarrafha, Braxton R Schuldt, Abhishek Sahasrabudhe, Tim Ahfeldt

iScience· July 2025

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Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by knockout.
Camille Goldman, Tatyana Kareva, Lily Sarrafha, Braxton R Schuldt, Abhishek Sahasrabudhe, Tim Ahfeldt

bioRxiv· June 2025

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Comparative study of enriched dopaminergic neurons from siblings with Gaucher disease discordant for parkinsonism.
Ellen Hertz, Gani Perez, Ying Hao, Krystyna Rytel, Charis Ma, Tim Ahfeldt

bioRxiv· February 2024

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Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson's disease.
Qian Wang, Minghui Wang, Insup Choi, Lily Sarrafha, Marianna Liang, Tim Ahfeldt

Sci Adv· January 2024

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Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model.
Gustavo Morrone Parfitt, Elena Coccia, Camille Goldman, Kristen Whitney, Ricardo Reyes, Tim Ahfeldt

Nat Commun· January 2024

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Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity.
Lily Sarrafha, Drew R Neavin, Gustavo M Parfitt, Ilya A Kruglikov, Kristen Whitney, Tim Ahfeldt

iScience· September 2023

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Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity.
Ana Catarina Ferreira, Brittany M Hemmer, Sarah M Philippi, Alejandro B Grau-Perales, Jacob L Rosenstadt, Tim Ahfeldt

Mol Psychiatry· September 2023

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Publisher Correction: A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides.
Kimberly C Paul, Richard C Krolewski, Edinson Lucumi Moreno, Jack Blank, Kristina M Holton, Tim Ahfeldt

Nat Commun· June 2023

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A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides.
Kimberly C Paul, Richard C Krolewski, Edinson Lucumi Moreno, Jack Blank, Kristina M Holton, Tim Ahfeldt

Nat Commun· May 2023

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A reference human induced pluripotent stem cell line for large-scale collaborative studies.
Caroline B Pantazis, Andrian Yang, Erika Lara, Justin A McDonough, Cornelis Blauwendraat, Tim Ahfeldt

Cell Stem Cell· December 2022

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Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy.
Alban Ordureau, Felix Kraus, Jiuchun Zhang, Heeseon An, Sookhee Park, Tim Ahfeldt

Mol Cell· December 2021

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Dysregulation of mitochondrial and proteolysosomal genes in Parkinson's disease myeloid cells.
Elisa Navarro, Evan Udine, Katia de Paiva Lopes, Madison Parks, Giulietta Riboldi, Tim Ahfeldt

Nat Aging· September 2021

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High-throughput generation of midbrain dopaminergic neuron organoids from reporter human pluripotent stem cells.
Lily Sarrafha, Gustavo M Parfitt, Ricardo Reyes, Camille Goldman, Elena Coccia, Tim Ahfeldt

STAR Protoc· June 2021

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Towards physiologically relevant human pluripotent stem cell (hPSC) models of Parkinson's disease.
Elena Coccia, Tim Ahfeldt

Stem Cell Res Ther· April 2021

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Modeling the complex genetic architectures of brain disease.
Michael B Fernando, Tim Ahfeldt, Kristen J Brennand

Nat Genet· April 2020

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Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons.
Tim Ahfeldt, Alban Ordureau, Christina Bell, Lily Sarrafha, Chicheng Sun

Stem Cell Reports· January 2020

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Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.
Alban Ordureau, Joao A Paulo, Wei Zhang, Tim Ahfeldt, Jiuchun Zhang

Mol Cell· April 2018

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Studying human disease using human neurons.
Tim Ahfeldt, Nadia K Litterman, Lee L Rubin

Brain Res· February 2017

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A TALEN genome-editing system for generating human stem cell-based disease models.
Qiurong Ding, Youn-Kyoung Lee, Esperance A K Schaefer, Derek T Peters, Adrian Veres, Tim Ahfeldt

Cell Stem Cell· February 2013

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Efficient culturing and genetic manipulation of human pluripotent stem cells.
Robert T Schinzel, Tim Ahfeldt, Frank H Lau, Youn-Kyoung Lee, Alicia Cowley

PLoS One· August 2012

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Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs.
Hongmei Mou, Rui Zhao, Richard Sherwood, Tim Ahfeldt, Allen Lapey

Cell Stem Cell· April 2012

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Pattern specification and immune response transcriptional signatures of pericardial and subcutaneous adipose tissue.
Frank H Lau, Rahul C Deo, Gregory Mowrer, Joshua Caplin, Tim Ahfeldt

PLoS One· February 2012

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Programming human pluripotent stem cells into white and brown adipocytes.
Tim Ahfeldt, Robert T Schinzel, Youn-Kyoung Lee, David Hendrickson, Adam Kaplan

Nat Cell Biol· January 2012

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Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.
Luigi Warren, Philip D Manos, Tim Ahfeldt, Yuin-Han Loh, Hu Li

Cell Stem Cell· November 2010

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From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.
Kiran Musunuru, Alanna Strong, Maria Frank-Kamenetsky, Noemi E Lee, Tim Ahfeldt

Nature· August 2010

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