Publications by authors named "Tim Mant"

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C286, an orally available retinoic acid receptor β agonist drug, regulates multiple pathways to achieve spinal cord injury repair.
Maria B Goncalves, Yue Wu, Earl Clarke, John Grist, Julien Moehlin, Tim Mant

Front Mol Neurosci· August 2024

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Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL-286, a novel retinoic acid receptor-β agonist for treatment of spinal cord injury, in male healthy participants.
Maria B Goncalves, Tim Mant, Jörg Täubel, Earl Clarke, Hana Hassanin

Br J Clin Pharmacol· December 2023

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Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran-Results of the phase 1 inhibitor cohort.
K John Pasi, Toshko Lissitchkov, Vasily Mamonov, Tim Mant, Margarita Timofeeva

J Thromb Haemost· June 2021

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Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants.
Charlotte H Maden, David Fairman, Michelle Chalker, Maria J Costa, William A Fahy, Tim Mant

Eur J Clin Pharmacol· June 2018

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The effects of house dust mite sublingual immunotherapy tablet on immunologic biomarkers and nasal allergen challenge symptoms.
Natasha C Gunawardana, Qing Zhao, Leonidas N Carayannopoulos, Kuenhi Tsai, Vladislav A Malkov, Tim Mant

J Allergy Clin Immunol· February 2018

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Pharmacokinetic equivalence, comparable safety, and immunogenicity of an adalimumab biosimilar product (M923) to Humira in healthy subjects.
Jan Hillson, Tim Mant, Molly Rosano, Carolyn Huntenburg, Mehrshid Alai-Safar

Pharmacol Res Perspect· February 2018

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Polypharmacy and Unplanned Hospitalizations in Patients with Rheumatoid Arthritis.
Maria Filkova, João Carvalho, Sam Norton, David Scott, Tim Mant

J Rheumatol· December 2017

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Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy.
K John Pasi, Savita Rangarajan, Pencho Georgiev, Tim Mant, Michael D Creagh

N Engl J Med· August 2017

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PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers.
Greg Coffey, Aradhana Rani, Andreas Betz, Yvonne Pak, Helena Haberstock-Debic, Tim Mant

J Clin Pharmacol· February 2017

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Comparison of the pharmacokinetics, safety, and immunogenicity of MSB11022, a biosimilar of adalimumab, with Humira(®) in healthy subjects.
Elizabeth Hyland, Tim Mant, Pantelis Vlachos, Neil Attkins, Martin Ullmann

Br J Clin Pharmacol· October 2016

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Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects.
Shirin Bruderer, Kaori Okubo, Hideya Mukai, Tim Mant, Jasper Dingemanse

Clin Ther· May 2016

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Is there a role of synovial biopsy in drug development?
Maria Filkova, Andrew Cope, Tim Mant, James Galloway

BMC Musculoskelet Disord· April 2016

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Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies.
Paul Martin, Michael Gillen, David Millson, Stuart Oliver, Clive Brealey, Tim Mant

Drugs R D· March 2016

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Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies.
Paul Martin, Michael Gillen, David Millson, Stuart Oliver, Clive Brealey, Tim Mant

Clin Ther· December 2015

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Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects.
Jason M Gow, Wayne H Tsuji, Gary J Williams, Daniel Mytych, David Sciberras, Tim Mant

Arthritis Res Ther· October 2015

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Pegylated, full-length, recombinant factor VIII for prophylactic and on-demand treatment of severe hemophilia A.
Barbara A Konkle, Oleksandra Stasyshyn, Pratima Chowdary, David H Bevan, Tim Mant

Blood· August 2015

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Pharmacokinetics and Tolerability of the Novel Oral Prostacyclin IP Receptor Agonist Selexipag.
Priska Kaufmann, Kaori Okubo, Shirin Bruderer, Tim Mant, Tetsuhiro Yamada

Am J Cardiovasc Drugs· June 2015

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Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies.
Muhammad Baluom, Elliott B Grossbard, Tim Mant, David T W Lau

Br J Clin Pharmacol· July 2013

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Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection.
Kari R Nations, Roberta Bursi, Peter Dogterom, Larry Ereshefsky, Lev Gertsik, Tim Mant

Drugs R D· September 2012

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DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial.
Suzanne Jones, Kirsten Evans, Hilary McElwaine-Johnn, Michaela Sharpe, John Oxford, Tim Mant

Vaccine· April 2009

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Two single-center, double-blind, randomized, placebo-controlled, phase I studies to investigate the tolerability and pharmacokinetics of CH-1504, an antifolate, in healthy male subjects.
Tim Mant, Stipo Jurcevic, Cameron Szakacs, Luthando Adams, John Boland

Clin Ther· January 2008

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Effect of oral posaconazole on the pharmacokinetics of cyclosporine and tacrolimus.
Angela Sansone-Parsons, Gopal Krishna, Monika Martinho, Bhavna Kantesaria, Steven Gelone, Tim G Mant

Pharmacotherapy· June 2007

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Albuterol HFA is as effective as albuterol CFC in preventing exercise-induced bronchoconstriction.
Richard J Hawksworth, Andrew P Sykes, Melissa Faris, Tim Mant, Tak H Lee

Ann Allergy Asthma Immunol· May 2002

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