Publications by authors named "Timo Rousu"

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Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes.
Toni Lassila, Timo Rousu, Sampo Mattila, Christophe Chesné, Olavi Pelkonen

J Pharm Biomed Anal· November 2015

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Reactive metabolites in early drug development: predictive in vitro tools.
Olavi Pelkonen, Markku Pasanen, Ari Tolonen, Mikko Koskinen, Jukka Hakkola, Timo Rousu

Curr Med Chem· August 2015

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Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases.
Hongbo Zhang, Anne Soikkeli, Ari Tolonen, Timo Rousu, Jouni Hirvonen

Toxicol In Vitro· December 2012

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Comparison of unit resolution SRM and TOF-MS at 12,000 mass resolution for quantitative bioanalysis of 11 steroids from human plasma.
Timo Rousu, Ari Tolonen

Bioanalysis· March 2012

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Use of comprehensive screening methods to detect selective human CAR activators.
Jenni Küblbeck, Tuomo Laitinen, Johanna Jyrkkärinne, Timo Rousu, Ari Tolonen

Biochem Pharmacol· December 2011

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Applicability of Generic Assays Based on Liquid Chromatography-Electrospray Mass Spectrometry to Study in vitro Metabolism of 55 Structurally Diverse Compounds.
Timo Rousu, Juho Hokkanen, Olavi R Pelkonen, Ari Tolonen

Front Pharmacol· July 2011

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Characterization of cyanide-trapped methylated metabonates formed during reactive drug metabolite screening in vitro.
Timo Rousu, Ari Tolonen

Rapid Commun Mass Spectrom· May 2011

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Effects of cell differentiation and assay conditions on the UDP-glucuronosyltransferase activity in Caco-2 cells.
Hongbo Zhang, Ari Tolonen, Timo Rousu, Jouni Hirvonen, Moshe Finel

Drug Metab Dispos· March 2011

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Comparison of triple quadrupole, hybrid linear ion trap triple quadrupole, time-of-flight and LTQ-Orbitrap mass spectrometers in drug discovery phase metabolite screening and identification in vitro--amitriptyline and verapamil as model compounds.
Timo Rousu, Jukka Herttuainen, Ari Tolonen

Rapid Commun Mass Spectrom· April 2010

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Comparison of metabolic stability and metabolite identification of 55 ECVAM/ICCVAM validation compounds between human and rat liver homogenates and microsomes - a preliminary analysis.
Olavi Pelkonen, Ari Tolonen, Timo Rousu, Larissa Tursas, Mia Turpeinen

ALTEX· January 2010

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Rapid detection and characterization of reactive drug metabolites in vitro using several isotope-labeled trapping agents and ultra-performance liquid chromatography/time-of-flight mass spectrometry.
Timo Rousu, Olavi Pelkonen, Ari Tolonen

Rapid Commun Mass Spectrom· March 2009

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