Publications by authors named "Ari Tolonen"

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Preclinical pharmacokinetics, metabolism, and disposition of NXE0041178, a novel orally bioavailable agonist of the GPR52 receptor with potential for treatment of schizophrenia and related psychiatric disorders.
Simon Poulter, Nigel Austin, Stephen P Watson, Sarah J Bucknell, M Alistair O'Brien, Ari Tolonen

Xenobiotica· March 2025

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Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues.
Anam Hammid, John K Fallon, Kati-Sisko Vellonen, Toni Lassila, Mika Reinisalo, Ari Tolonen

Eur J Pharm Sci· December 2023

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Extrahepatic in vitro metabolism of peptides; comparison of human kidney and intestinal S9 fraction, human plasma and proximal tubule cells, using cyclosporine A, leuprorelin, and cetrorelix as model compounds.
Juha Jyrkäs, Toni Lassila, Ari Tolonen

J Pharm Biomed Anal· February 2023

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Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues.
Anam Hammid, John K Fallon, Toni Lassila, Paula Vieiro, Anusha Balla, Ari Tolonen

Drug Metab Dispos· December 2022

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Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism.
Mikko Karpale, Aki Juhani Käräjämäki, Outi Kummu, Helena Gylling, Tuulia Hyötyläinen, Ari Tolonen

Br J Pharmacol· June 2021

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Hepatic in vitro metabolism of peptides; Comparison of human liver S9, hepatocytes and Upcyte hepatocytes with cyclosporine A, leuprorelin, desmopressin and cetrorelix as model compounds.
Juha Jyrkäs, Ari Tolonen

J Pharm Biomed Anal· March 2021

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Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues.
Anam Hammid, John K Fallon, Toni Lassila, Giulia Salluce, Philip C Smith, Ari Tolonen

Mol Pharm· March 2021

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4-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.
Tuire Salonurmi, Heba Nabil, Justiina Ronkainen, Tuulia Hyötyläinen, Heidi Hautajärvi, Ari Tolonen

Front Pharmacol· March 2020

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Pharmacokinetics of intra-articular vitamin D analogue calcipotriol in sheep and metabolism in human synovial and mesenchymal stromal cells.
Jere Huovinen, Maija Haj Hussain, Markus Niemelä, Sakari Laaksonen, Hanna-Marja Voipio, Ari Tolonen

J Steroid Biochem Mol Biol· April 2019

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In vitro modulation of cytochrome P450 isozymes and pharmacokinetics of caffeine by extracts of Hibiscus sabdariffa Linn calyx.
Johnson Segun Showande, Sharon Iyobor Igbinoba, Marena Kajula, Juho Hokkanen, Ari Tolonen

J Basic Clin Physiol Pharmacol· April 2019

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Potential inhibition of major human cytochrome P450 isoenzymes by selected tropical medicinal herbs-Implication for herb-drug interactions.
Segun Johnson Showande, Titilayo Oyelola Fakeye, Marena Kajula, Juho Hokkanen, Ari Tolonen

Food Sci Nutr· January 2019

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Quantitative analysis of 4β- and 4α‑hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS.
Heidi Hautajärvi, Janne Hukkanen, Miia Turpeinen, Sampo Mattila, Ari Tolonen

J Chromatogr B Analyt Technol Biomed Life Sci· November 2018

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Tandem mass spectrometric analysis of S- and N-linked glutathione conjugates of pulegone and menthofuran and identification of P450 enzymes mediating their formation.
Toni Lassila, Sampo Mattila, Miia Turpeinen, Olavi Pelkonen, Ari Tolonen

Rapid Commun Mass Spectrom· April 2016

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Bridged Epipolythiodiketopiperazines from Penicillium raciborskii, an Endophytic Fungus of Rhododendron tomentosum Harmaja.
Marena Kajula, Joshua M Ward, Ari Turpeinen, Mysore V Tejesvi, Juho Hokkanen, Ari Tolonen

J Nat Prod· April 2016

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Metabolism and metabolite profiles in vitro and in vivo of ospemifene in humans and preclinical species.
Jouko Uusitalo, Miia Turpeinen, Ari Tolonen, Pasi Koskimies, Risto Lammintausta

Drug Metab Pers Ther· March 2016

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Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity.
Jenni Küblbeck, Jenni J Hakkarainen, Aleksanteri Petsalo, Kati-Sisko Vellonen, Ari Tolonen

J Pharm Sci· February 2016

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Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated.
Toni Lassila, Juho Hokkanen, Sanna-Mari Aatsinki, Sampo Mattila, Miia Turpeinen, Ari Tolonen

Chem Res Toxicol· December 2015

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Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes.
Toni Lassila, Timo Rousu, Sampo Mattila, Christophe Chesné, Olavi Pelkonen, Ari Tolonen

J Pharm Biomed Anal· November 2015

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Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts.
Toni Lassila, Sampo Mattila, Miia Turpeinen, Ari Tolonen

Rapid Commun Mass Spectrom· October 2015

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Reactive metabolites in early drug development: predictive in vitro tools.
Olavi Pelkonen, Markku Pasanen, Ari Tolonen, Mikko Koskinen, Jukka Hakkola

Curr Med Chem· August 2015

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Analytical challenges for conducting rapid metabolism characterization for QIVIVE.
Ari Tolonen, Olavi Pelkonen

Toxicology· June 2015

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Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts.
Toni Lassila, Sampo Mattila, Miia Turpeinen, Ari Tolonen

Rapid Commun Mass Spectrom· March 2015

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In vitro inhibitory activities of the extract of Hibiscus sabdariffa L. (family Malvaceae) on selected cytochrome P450 isoforms.
Showande Segun Johnson, Fakeye Titilayo Oyelola, Tolonen Ari, Hokkanen Juho

Afr J Tradit Complement Altern Med· May 2014

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Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations.
Ari Tolonen, Pasi Koskimies, Miia Turpeinen, Jouko Uusitalo, Risto Lammintausta

Drug Metabol Drug Interact· March 2014

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Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.
Terhi Lehtinen, Ari Tolonen, Miia Turpeinen, Jouko Uusitalo, Jouni Vuorinen

Biopharm Drug Dispos· October 2013

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