Publications by authors named "Timothy A Graubert"

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OGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis.
Christina Mayerhofer, Dan Li, Trine Kristiansen, Ernst Mayerhofer, Azeem Sharda, Timothy A Graubert

Cell Metab· October 2025

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Sensitivity to ATR-CHK1 pathway inhibition in AML/MDS is enhanced by mutations and reduced by RUNX1 loss.
Samuli Eldfors, Sumit Rai, Vineet Sharma, Tareq Hossan, Claudia Cabrera Pastrana, Timothy A Graubert

bioRxiv· October 2025

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and myeloid neoplasm-associated hotspot mutations induce distinct hematopoietic phenotypes in mice.
Michael O Alberti, Sridhar Nonavinkere Srivatsan, Jin Shao, Dennis L Fei, Mengou Zhu, Timothy A Graubert

Res Sq· May 2025

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Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis.
Jooho Chung, Mounica Vallurupalli, Sarah Noel, Gail Schor, YuhJong Liu, Timothy A Graubert

bioRxiv· May 2025

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Integrative cytogenetic and molecular studies unmask "chromosomal mimicry" in hematologic malignancies.
Melissa Zhao, Scott Ryall, Samuel J Brody, Amyah C Harris, Kristin Cabral, Timothy A Graubert

Blood Adv· March 2025

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R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription-Replication Conflicts.
Zhiyan Silvia Liu, Sayantani Sinha, Maxwell Bannister, Axia Song, Erica Arriaga-Gomez, Timothy A Graubert

Cancer Res· February 2024

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Supporting Patients with Cancer after Dobbs v. Jackson Women's Health Organization.
Andrew G Shuman, Matti S Aapro, Benjamin Anderson, Katherine Arbour, Pedro C Barata, Timothy A Graubert

Oncologist· August 2022

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Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.
Dirk Brehmer, Lijs Beke, Tongfei Wu, Hillary J Millar, Christopher Moy, Timothy A Graubert

Mol Cancer Ther· December 2021

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U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice.
Brian A Wadugu, Sridhar Nonavinkere Srivatsan, Amanda Heard, Michael O Alberti, Matthew Ndonwi, Timothy A Graubert

J Clin Invest· November 2021

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A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex.
Rakesh Chatrikhi, Callen F Feeney, Mary J Pulvino, Georgios Alachouzos, Andrew J MacRae, Timothy A Graubert

Cell Chem Biol· August 2021

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Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy.
Vinayak Venkataraman, Keagan S Casey, Maristela Onozato, Paola Dal Cin, Valentina Nardi, Timothy A Graubert

Leukemia· November 2020

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SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS.
Luca Malcovati, Kristen Stevenson, Elli Papaemmanuil, Donna Neuberg, Rafael Bejar, Timothy A Graubert

Blood· July 2020

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Clonal hematopoiesis and measurable residual disease assessment in acute myeloid leukemia.
Robert P Hasserjian, David P Steensma, Timothy A Graubert, Benjamin L Ebert

Blood· May 2020

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A phase 1 study of the antibody-drug conjugate brentuximab vedotin with re-induction chemotherapy in patients with CD30-expressing relapsed/refractory acute myeloid leukemia.
Rupa Narayan, Traci M Blonquist, Ashkan Emadi, Robert P Hasserjian, Meghan Burke, Timothy A Graubert

Cancer· March 2020

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Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial.
Andrew M Brunner, Traci M Blonquist, Daniel J DeAngelo, Malgorzata McMasters, Geoffrey Fell, Timothy A Graubert

Lancet Haematol· February 2020

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TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.
Detlef Haase, Kristen E Stevenson, Donna Neuberg, Jaroslaw P Maciejewski, Aziz Nazha, Timothy A Graubert

Leukemia· July 2019

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Targeting R-loop-associated ATR response in myelodysplastic syndrome.
Hai Dang Nguyen, Lee Zou, Timothy A Graubert

Oncotarget· April 2019

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Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.
Peter van Galen, Volker Hovestadt, Marc H Wadsworth Ii, Travis K Hughes, Gabriel K Griffin, Timothy A Graubert

Cell· March 2019

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Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia.
Andrew M Brunner, Donna S Neuberg, Seth A Wander, Hossein Sadrzadeh, Karen K Ballen, Timothy A Graubert

Cancer· February 2019

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Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.
Matthew J Christopher, Allegra A Petti, Michael P Rettig, Christopher A Miller, Ezhilarasi Chendamarai, Timothy A Graubert

N Engl J Med· December 2018

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Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes.
Hai Dang Nguyen, Wan Yee Leong, Weiling Li, Pavankumar N G Reddy, Jack D Sullivan, Timothy A Graubert

Cancer Res· September 2018

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Mutation Clearance after Transplantation for Myelodysplastic Syndrome.
Eric J Duncavage, Meagan A Jacoby, Gue Su Chang, Christopher A Miller, Natasha Edwin, Timothy A Graubert

N Engl J Med· September 2018

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High -mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML.
Sanjay S Patel, Frank C Kuo, Christopher J Gibson, David P Steensma, Robert J Soiffer, Timothy A Graubert

Blood· June 2018

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Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.
Meagan A Jacoby, Eric J Duncavage, Gue Su Chang, Christopher A Miller, Jin Shao, Timothy A Graubert

JCI Insight· March 2018

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Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.
Terrence N Wong, Christopher A Miller, Matthew R M Jotte, Nusayba Bagegni, Jack D Baty, Timothy A Graubert

Nat Commun· January 2018

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